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UbcH7 Protein, Active Proteins Molecular Depot
UbcH7 Protein, Active Proteins Molecular Depot

UbcH7 Protein, Active

$795.00

    Catalog Number: B2018566 (5 µg)

    Ubiquitin-conjugating enzyme E2 L3 (UBE2L3), also known as UbcH7, is a protein that plays a key role in the ubiquitination pathway. When UbcH7 is active, it functions as an E2 ubiquitin-conjugating enzyme, facilitating the transfer of ubiquitin from an E1 enzyme to a target protein with the help of an E3 ubiquitin ligase. This process is essential for the regulation of various cellular processes. This product has been used as a molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request.

    Products are for in vitro research use only (RUO).

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What's Included

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VR Headset

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2 Touch Controllers

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Charging Cable

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Power Adapter

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Glasses Spacer

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UbcH7 Protein, Active

Catalog number: B2018566
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 5 µg
Molecular Weight or Concentration: N/A
Supplied as: Solution
Applications: a molecular tool for various biochemical applications
Storage: -20°C
Keywords: Ubiquitin-conjugating enzyme E2 L3, L-UBC, Ubiquitin carrier protein L3, Ubiquitin-conjugating enzyme E2-F1, Ubiquitin-protein ligase L3, UBE2L3, UBCE7
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References

  • Niu K, Fang H, Chen Z, Zhu Y, Tan Q, Wei D, Li Y, Balajee AS, Zhao Y. USP33 deubiquitinates PRKN/parkin and antagonizes its role in mitophagy Autophagy. 2020 Apr;16(4):724-734.
  • Verma S, Ismail A, Gao X, Fu G, Li X, O’Malley BW, Nawaz Z. The ubiquitin-conjugating enzyme UBCH7 acts as a coactivator for steroid hormone receptors Mol Cell Biol. 2004 Oct;24(19):8716-26.
  • Whitcomb EA, Tsai YC, Basappa J, Liu K, Le Feuvre AK, Weissman AM, Taylor A. Stabilization of p27(Kip1)/CDKN1B by UBCH7/UBE2L3 catalyzed ubiquitinylation: a new paradigm in cell-cycle control FASEB J. 2019 Jan;33(1):1235-1247.
  • Wenzel DM, Lissounov A, Brzovic PS, Klevit RE. UBCH7 reactivity profile reveals parkin and HHARI to be RING/HECT hybrids Nature. 2011 Jun 2;474(7349):105-8.
  • Singh A, Tiwari S, Singh S. Pirh2 modulates amyloid-β aggregation through the regulation of glucose-regulated protein 78 and chaperone-mediated signaling J Cell Physiol. 2023 Dec;238(12):2841-2854.
  • Zheng N, Wang P, Jeffrey PD, Pavletich NP. Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases Cell. 2000 Aug 18;102(4):533-9.
  • Moynihan TP, Ardley HC, Nuber U, Rose SA, Jones PF, Markham AF, Scheffner M, Robinson PA. The ubiquitin-conjugating enzymes UbcH7 and UbcH8 interact with RING finger/IBR motif-containing domains of HHARI and H7-AP1 J Biol Chem. 1999 Oct 22;274(43):30963-8.
  • Zhang X, Huo C, Liu Y, Su R, Zhao Y, Li Y. Mechanism and Disease Association With a Ubiquitin Conjugating E2 Enzyme: UBE2L3 Front Immunol. 2022 Feb 21;13:793610.
  • Condos TE, Dunkerley KM, Freeman EA, Barber KR, Aguirre JD, Chaugule VK, Xiao Y, Konermann L, Walden H, Shaw GS. Synergistic recruitment of UbcH7~Ub and phosphorylated Ubl domain triggers parkin activation EMBO J. 2018 Dec 3;37(23):e100014.

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    Blue Tiger Scientific is an independent third-party distributor of select products manufactured by Molecular Depot LLC. By purchasing from bluetigerscientific.com, you (“the Customer”) agree to the following terms, adapted from Molecular Depot’s original conditions:

    Product Use & Eligibility
    Products are for in vitro research use only (RUO). They are not intended for human or animal use, diagnosis, therapy, resale to consumers, or residential delivery. Sales are limited to verified business addresses.

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Product Resources:

Copy of Technical Specifications

FeatureDetails
Viewing Head Siedentopf type trinocular head, inclined at 30°, Interpupillary adjustment 53mm to 75mm, graduated diopter on left eyetube (30mm I.D. eyetubes)
Eyepieces SWH10X Widefield high eyepoint eyepiece, Field No. 22, tube O.D. 30.0 mm
Nosepiece Quintuple
Quintuple LWD Planachromat Phase 10x, 20x
Condenser TC Condenser N.A. 0.30, W.D. 73.0mm
Stage180mm(X) x 245mm(Y) plain stage with replaceable glass insert with 45mm opening, Glass Stage plate insert
IlluminationKoehler without iris, with phase slider, 3W LED
WarrantyLIMITED LIFETIME WARRANTY

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