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UbcH5b Conjugating Enzyme Proteins Molecular Depot
UbcH5b Conjugating Enzyme Proteins Molecular Depot
UbcH5b Conjugating Enzyme Proteins Molecular Depot
UbcH5b Conjugating Enzyme Proteins Molecular Depot

UbcH5b Conjugating Enzyme

$1,995.00

    Catalog Number: B2018695 (10 ug)

    UbcH5b is a type of ubiquitin-conjugating enzyme, also known as E2 enzyme. UbcH5b specifically belongs to the UbcH5 family of E2 enzymes and is involved in transferring ubiquitin molecules to target proteins in the ubiquitination pathway. This product has been used as a molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request.

    Products are for in vitro research use only (RUO).

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What's Included

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VR Headset

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2 Touch Controllers

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Charging Cable

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Power Adapter

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UbcH5b Conjugating Enzyme

Catalog number: B2018695
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 10 ug
Molecular Weight or Concentration: 17 kDa
Supplied as: Solution
Applications: a molecular tool for various biochemical applications
Storage: -80°C
Keywords: E2 Enzyme
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References

  • Huang M, Zhou Y, Duan D, Yang C, Zhou Z, Li F, Kong Y, Hsieh YC, Zhang R, Ding W, Xiao W, Puno P, Chen C. Targeting ubiquitin conjugating enzyme UbcH5b by a triterpenoid PC3-15 from Schisandra plants sensitizes triple-negative breast cancer cells to lapatinib Cancer Lett. 2021 Apr 28;504:125-136.
  • Houben K, Dominguez C, van Schaik FM, Timmers HT, Bonvin AM, Boelens R. Solution structure of the ubiquitin-conjugating enzyme UbcH5B J Mol Biol. 2004 Nov 19;344(2):513-26.
  • Winkler GS, Albert TK, Dominguez C, Legtenberg YI, Boelens R, Timmers HT. An altered-specificity ubiquitin-conjugating enzyme/ubiquitin-protein ligase pair J Mol Biol. 2004 Mar 12;337(1):157-65.
  • Buetow L, Gabrielsen M, Anthony NG, Dou H, Patel A, Aitkenhead H, Sibbet GJ, Smith BO, Huang DT. Activation of a primed RING E3-E2-ubiquitin complex by non-covalent ubiquitin Mol Cell. 2015 Apr 16;58(2):297-310.
  • Saville MK, Sparks A, Xirodimas DP, Wardrop J, Stevenson LF, Bourdon JC, Woods YL, Lane DP. Regulation of p53 by the ubiquitin-conjugating enzymes UbcH5B/C in vivo J Biol Chem. 2004 Oct 1;279(40):42169-81.
  • Ozkan E, Yu H, Deisenhofer J. Mechanistic insight into the allosteric activation of a ubiquitin-conjugating enzyme by RING-type ubiquitin ligases Proc Natl Acad Sci U S A. 2005 Dec 27;102(52):18890-5.
  • Patel A, Sibbet GJ, Huang DT. Structural insights into non-covalent ubiquitin activation of the cIAP1-UbcH5B∼ubiquitin complex J Biol Chem. 2019 Jan 25;294(4):1240-1249.
  • Li S, Liang YH, Mariano J, Metzger MB, Stringer DK, Hristova VA, Li J, Randazzo PA, Tsai YC, Ji X, Weissman AM. Insights into Ubiquitination from the Unique Clamp-like Binding of the RING E3 AO7 to the E2 UbcH5B J Biol Chem. 2015 Dec 18;290(51):30225-39.
  • DiBello A, Datta AB, Zhang X, Wolberger C. Role of E2-RING Interactions in Governing RNF4-Mediated Substrate Ubiquitination J Mol Biol. 2016 Nov 20;428(23):4639-4650.

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    Products are for in vitro research use only (RUO). They are not intended for human or animal use, diagnosis, therapy, resale to consumers, or residential delivery. Sales are limited to verified business addresses.

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Product Resources:

Manual Manual
Brochure Brochure

Copy of Technical Specifications

FeatureDetails
Viewing Head Siedentopf type trinocular head, inclined at 30°, Interpupillary adjustment 53mm to 75mm, graduated diopter on left eyetube (30mm I.D. eyetubes)
Eyepieces SWH10X Widefield high eyepoint eyepiece, Field No. 22, tube O.D. 30.0 mm
Nosepiece Quintuple
Quintuple LWD Planachromat Phase 10x, 20x
Condenser TC Condenser N.A. 0.30, W.D. 73.0mm
Stage180mm(X) x 245mm(Y) plain stage with replaceable glass insert with 45mm opening, Glass Stage plate insert
IlluminationKoehler without iris, with phase slider, 3W LED
WarrantyLIMITED LIFETIME WARRANTY

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