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Sphingosine Kinase 2 Active from Mouse Enzymes Molecular Depot
Sphingosine Kinase 2 Active from Mouse Enzymes Molecular Depot
Sphingosine Kinase 2 Active from Mouse Enzymes Molecular Depot
Sphingosine Kinase 2 Active from Mouse Enzymes Molecular Depot

Sphingosine Kinase 2 Active from Mouse

$1,295.00

    Catalog Number: B2016601 (5 ug)

    Sphingosine Kinase 2 Active from Mouse is a high quality Sphingosine kinase 2 (SphK2) is an enzyme that plays a key role in sphingolipid metabolism by catalyzing the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P). S1P is a bioactive lipid molecule involved in various cellular processes such as cell proliferation, survival, and migration.

    Products are for in vitro research use only (RUO).

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What's Included

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VR Headset

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2 Touch Controllers

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Charging Cable

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Power Adapter

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Glasses Spacer

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Sphingosine Kinase 2 Active from Mouse

Catalog number: B2016601
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 5 ug
Molecular Weight or Concentration: 68 kDa
Supplied as: Solution
Applications: a molecular tool for various biochemical applications
Storage: −80°C
Keywords: SK2, SPHK2, SPK 2
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References

  • Wang D, Han S, Lv G, Hu Y, Zhuo W, Zeng Z, Tang J, Huang Y, Wang F, Wang J, Zhao Y, Zhao G. Pancreatic Acinar Cells-Derived Sphingosine-1-Phosphate Contributes to Fibrosis of Chronic Pancreatitis via Inducing Autophagy and Activation of Pancreatic Stellate Cells Gastroenterology. 2023 Dec;165(6):1488-1504.e20.
  • Weigel C, Maczis MA, Palladino END, Green CD, Maceyka M, Guo C, Wang XY, Dozmorov MG, Milstien S, Spiegel S. Sphingosine Kinase 2 in Stromal Fibroblasts Creates a Hospitable Tumor Microenvironment in Breast Cancer Cancer Res. 2023 Feb 15;83(4):553-567.
  • Li L, Wang H, Zhang J, Sha Y, Wu F, Wen S, He L, Sheng L, You Q, Shi M, Liu L, Zhou H. SPHK1 deficiency protects mice from acetaminophen-induced ER stress and mitochondrial permeability transition Cell Death Differ. 2020 Jun;27(6):1924-1937.
  • Ranasinghe ADCU, Holohan M, Borger KM, Donahue DL, Kuc RD, Gerig M, Kim A, Ploplis VA, Castellino FJ, Schwarz MA. Altered Smooth Muscle Cell Histone Acetylome by the SPHK2/S1P Axis Promotes Pulmonary Hypertension Circ Res. 2023 Sep 29;133(8):704-719.
  • Rohrbach T, Maceyka M, Spiegel S. Sphingosine kinase and sphingosine-1-phosphate in liver pathobiology Crit Rev Biochem Mol Biol. 2017 Oct;52(5):543-553.
  • Xie D, Hu G, Chen C, Ahmadinejad F, Wang W, Li PL, Gewirtz DA, Li N. Loss of sphingosine kinase 2 protects against cisplatin-induced kidney injury Am J Physiol Renal Physiol. 2022 Sep 1;323(3):F322-F334.
  • Inoue T, Nakamura Y, Tanaka S, Kohro T, Li LX, Huang L, Yao J, Kawamura S, Inoue R, Nishi H, Fukaya D, Uni R, Hasegawa S, Inagi R, Umene R, Wu CH, Ye H, Bajwa A, Rosin DL, Ishihara K, Nangaku M, Wada Y, Okusa MD. Bone marrow stromal cell antigen-1 (CD157) regulated by sphingosine kinase 2 mediates kidney fibrosis Front Med (Lausanne). 2022 Oct 4;9:993698.
  • Qi H, Cole J 2nd, Grambergs RC, Gillenwater JR, Mondal K, Khanam S, Dutta S, Stiles M, Proia RL, Allegood J, Mandal N. Sphingosine Kinase 2 Phosphorylation of FTY720 is Unnecessary for Prevention of Light-Induced Retinal Damage Sci Rep. 2019 May 23;9(1):7771.
  • Zhang ZS, Liu YY, He SS, Bao DQ, Wang HC, Zhang J, Peng XY, Zang JT, Zhu Y, Wu Y, Li QH, Li T, Liu LM. Pericytes protect rats and mice from sepsis-induced injuries by maintaining vascular reactivity and barrier function: implication of miRNAs and microvesicles Mil Med Res. 2023 Mar 13;10(1):13.

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Product Resources:

Manual Manual
Brochure Brochure

Copy of Technical Specifications

FeatureDetails
Viewing Head Siedentopf type trinocular head, inclined at 30°, Interpupillary adjustment 53mm to 75mm, graduated diopter on left eyetube (30mm I.D. eyetubes)
Eyepieces SWH10X Widefield high eyepoint eyepiece, Field No. 22, tube O.D. 30.0 mm
Nosepiece Quintuple
Quintuple LWD Planachromat Phase 10x, 20x
Condenser TC Condenser N.A. 0.30, W.D. 73.0mm
Stage180mm(X) x 245mm(Y) plain stage with replaceable glass insert with 45mm opening, Glass Stage plate insert
IlluminationKoehler without iris, with phase slider, 3W LED
WarrantyLIMITED LIFETIME WARRANTY

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