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Recombinant ITK (352-620) Protein Proteins Molecular Depot
Recombinant ITK (352-620) Protein Proteins Molecular Depot
Recombinant ITK (352-620) Protein Proteins Molecular Depot
Recombinant ITK (352-620) Protein Proteins Molecular Depot

Recombinant ITK (352-620) Protein

$1,095.00

    Catalog Number: B2017560 (10 µg)

    Recombinant ITK (352-620) Protein is a specific portion of the Interleukin-2-inducible T-cell kinase (ITK) protein. This recombinant protein is used in research settings to study the function and interactions of ITK in cellular signaling pathways related to immune responses. ITK is a key enzyme involved in T-cell activation and signaling, making it an important target for studying immune system function. This product has been used as a molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request.

    Products are for in vitro research use only (RUO).

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What's Included

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VR Headset

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2 Touch Controllers

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Charging Cable

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Power Adapter

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Glasses Spacer

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Recombinant ITK (352-620) Protein

Catalog number: B2017560
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 10 µg
Molecular Weight or Concentration: 31.8 kDa
Supplied as: SOLUTION
Applications: a molecular tool for various biochemical applications
Storage: -80°C
Keywords: IL-2 Inducible T-Cell Kinase, Tyrosine-Protein Kinase LYK, EMT, LYK, LPFS1
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References

  • Qi Q, August A. Keeping the (kinase) party going: SLP-76 and ITK dance to the beat Sci STKE. 2007 Jul 24;2007(396):pe39.
  • Hussain A, Yu L, Faryal R, Mohammad DK, Mohamed AJ, Smith CI. TEC family kinases in health and disease–loss-of-function of BTK and ITK and the gain-of-function fusions ITK-SYK and BTK-SYK FEBS J. 2011 Jun;278(12):2001-10.
  • Raab M, Cai YC, Bunnell SC, Heyeck SD, Berg LJ, Rudd CE. p56Lck and p59Fyn regulate CD28 binding to phosphatidylinositol 3-kinase, growth factor receptor-bound protein GRB-2, and T cell-specific protein-tyrosine kinase ITK: implications for T-cell costimulation Proc Natl Acad Sci U S A. 1995 Sep 12;92(19):8891-5.
  • Devkota S, Joseph RE, Boyken SE, Fulton DB, Andreotti AH. An Autoinhibitory Role for the Pleckstrin Homology Domain of Interleukin-2-Inducible Tyrosine Kinase and Its Interplay with Canonical Phospholipid Recognition Biochemistry. 2017 Jun 13;56(23):2938-2949.
  • Bunnell SC, Diehn M, Yaffe MB, Findell PR, Cantley LC, Berg LJ. Biochemical interactions integrating Itk with the T cell receptor-initiated signaling cascade J Biol Chem. 2000 Jan 21;275(3):2219-30.
  • Hallumi E, Shalah R, Lo WL, Corso J, Oz I, Beach D, Wittman S, Isenberg A, Sela M, Urlaub H, Weiss A, Yablonski D. Itk Promotes the Integration of TCR and CD28 Costimulation through Its Direct Substrates SLP-76 and Gads J Immunol. 2021 May 15;206(10):2322-2337.
  • Brazin KN, Mallis RJ, Fulton DB, Andreotti AH. Regulation of the tyrosine kinase Itk by the peptidyl-prolyl isomerase cyclophilin A Proc Natl Acad Sci U S A. 2002 Feb 19;99(4):1899-904.
  • Bunnell SC, Henry PA, Kolluri R, Kirchhausen T, Rickles RJ, Berg LJ. Identification of Itk/Tsk Src homology 3 domain ligands J Biol Chem. 1996 Oct 11;271(41):25646-56.
  • Bach MP, Hug E, Werner M, Holch J, Sprissler C, Pechloff K, Zirlik K, Zeiser R, Dierks C, Ruland J, Jumaa H. Premature terminal differentiation protects from deregulated lymphocyte activation by ITK-Syk J Immunol. 2014 Feb 1;192(3):1024-33.

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    Blue Tiger Scientific is an independent third-party distributor of select products manufactured by Molecular Depot LLC. By purchasing from bluetigerscientific.com, you (“the Customer”) agree to the following terms, adapted from Molecular Depot’s original conditions:

    Product Use & Eligibility
    Products are for in vitro research use only (RUO). They are not intended for human or animal use, diagnosis, therapy, resale to consumers, or residential delivery. Sales are limited to verified business addresses.

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    All purchases are prepaid and non-refundable once confirmed. Pricing is in USD and subject to change without notice.

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Product Resources:

Manual Manual
Brochure Brochure

Copy of Technical Specifications

FeatureDetails
Viewing Head Siedentopf type trinocular head, inclined at 30°, Interpupillary adjustment 53mm to 75mm, graduated diopter on left eyetube (30mm I.D. eyetubes)
Eyepieces SWH10X Widefield high eyepoint eyepiece, Field No. 22, tube O.D. 30.0 mm
Nosepiece Quintuple
Quintuple LWD Planachromat Phase 10x, 20x
Condenser TC Condenser N.A. 0.30, W.D. 73.0mm
Stage180mm(X) x 245mm(Y) plain stage with replaceable glass insert with 45mm opening, Glass Stage plate insert
IlluminationKoehler without iris, with phase slider, 3W LED
WarrantyLIMITED LIFETIME WARRANTY

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