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Jones Reagent (Highly Pure) Chemicals Molecular Depot
Jones Reagent (Highly Pure) Chemicals Molecular Depot
Jones Reagent (Highly Pure) Chemicals Molecular Depot
Jones Reagent (Highly Pure) Chemicals Molecular Depot

Jones Reagent (Highly Pure)

$395.00

    Catalog Number: B2012852 (25 mL)

    Jones Reagent (Highly Pure) is a 25 mL biotechnology-grade solution of chromium trioxide in aqueous sulfuric acid. This classic oxidizing reagent is widely used for the oxidation of primary alcohols to carboxylic acids and secondary alcohols to ketones in synthetic and biochemical research. Ready-to-use format ensures convenience and reproducibility in small-scale oxidation reactions. Custom bulk amounts of this product are available upon request.

    Products are for in vitro research use only (RUO).

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Jones Reagent (Highly Pure) – Research Use Only

Jones Reagent (Highly Pure) is a biotechnology-grade solution of chromium trioxide in aqueous sulfuric acid, supplied as a 25 mL ready-to-use reagent (Catalog #B2012852). This classic oxidizing mixture is widely used in organic and biochemical laboratories for the selective oxidation of primary alcohols to carboxylic acids and secondary alcohols to ketones under mild aqueous conditions.

Catalog number: B2012852
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 25 mL
Molecular Weight or Concentration: N/A
Supplied as: Solution
Applications: Oxidation of primary alcohols to carboxylic acids, secondary alcohols to ketones, and related synthetic transformations in organic and biochemical research
Storage: 2-8°C
Keywords: Jone′s reagent, Chromium trioxide solution in sulfuric acid, Sulfuric acid-chromium trioxide mixture
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

Scientific Overview

Jones Reagent is a chromic acid-based oxidizing system consisting of chromium trioxide dissolved in aqueous sulfuric acid. It is a powerful and widely used reagent for the oxidation of alcohols: primary alcohols are oxidized to carboxylic acids, while secondary alcohols are converted to ketones. The reagent operates under aqueous acidic conditions and is valued for its reliability, simplicity, and broad applicability in synthetic organic chemistry and biochemical research.

This Jones Reagent (Highly Pure) is suitable for:

  • Oxidation of primary alcohols to carboxylic acids
  • Oxidation of secondary alcohols to ketones
  • Synthetic transformations requiring a strong, water-compatible oxidant
  • Preparation of carbonyl compounds in small-scale research reactions
  • Method development and optimization in organic synthesis workflows

Usage & Handling Guidance

Store at 2–8 °C. The solution is ready-to-use but should be handled with care due to its strong oxidizing nature and corrosive properties. Perform reactions in a fume hood. Typical procedures involve adding the reagent dropwise to a solution of the substrate in acetone or another suitable solvent at 0–25 °C. Monitor the reaction by TLC and quench excess oxidant with isopropanol or sodium bisulfite when complete.

  • Recommended applications: Alcohol oxidation in synthetic and biochemical research
  • Reaction conditions: Usually performed in acetone at 0–25 °C; optimize time and equivalents for each substrate
  • Safety note: Highly corrosive and oxidizing — use appropriate PPE and work in a fume hood
  • Handling: Avoid contact with skin, eyes, and combustible materials; neutralize spills appropriately

What You Get

  • 25 mL Jones Reagent (Highly Pure) as a ready-to-use solution
  • Biotechnology-grade chromium trioxide in sulfuric acid
  • Convenient volume for multiple small-scale oxidation reactions
  • High-purity formulation suitable for reproducible synthetic work
  • For research use only (RUO)

Why Researchers Choose It

  • Ready-to-use solution format eliminates the need for in-house preparation
  • Reliable reagent for the oxidation of primary and secondary alcohols
  • Biotechnology-grade purity supports consistent and reproducible results
  • Convenient 25 mL size ideal for research-scale synthetic workflows
  • Well-established chemistry with extensive literature support

Frequently Asked Questions (FAQ)

  • What is Jones Reagent used for?
    It is a classic oxidizing agent used to convert primary alcohols to carboxylic acids and secondary alcohols to ketones.
  • What is the composition of this reagent?
    It is a solution of chromium trioxide (CrO₃) in aqueous sulfuric acid.
  • What safety precautions are required?
    Jones Reagent is highly corrosive and oxidizing. Use in a fume hood, wear appropriate PPE, and handle with care.
  • How should I store the product?
    Store at 2–8 °C. Keep the container tightly closed and protect from light if possible.
  • Can this reagent be used with sensitive functional groups?
    It is a strong oxidant; compatibility with other functional groups should be tested on a small scale first.
This product is for Research Use Only (RUO). It is not intended for diagnostic or therapeutic use in humans or animals.

References

  • Solaja BA, Milić DR, Dosen-Mićović LI. Oxidation of steroidal 5-en-3 beta-ols with Jones reagent in ether. Steroids. 1994 May;59(5):330-4. Reference
  • Bowden K, Heilbron IM, Jones ERH, Weedon BCL. 13. Researches on acetylenic compounds. Part I. The preparation of acetylenic ketones by oxidation of acetylenic carbinols and glycols. J Chem Soc. 1946:39-45. Reference
  • Heilbron IM, Jones ERH, Sondheimer F. 129. Researches on acetylenic compounds. Part XV. The oxidation of primary acetylenic carbinols and glycols. J Chem Soc. 1949:604-10. Reference
  • Meinwald J, Crandall J, Hymans WE. The Jones oxidation of cyclopropanols. Org Synth. 1965;45:77. Reference
  • Lou JD, Gao C, Ma Y, Huang L, Li L. Selective oxidation of benzyl and secondary alcohols with Jones reagent in the presence of a catalytic amount of iodine. Synth Commun. 2008;38(2):261-6. Reference
  • Freeman F. Chromic Acid. Encyclopedia of Reagents for Organic Synthesis. 2001. Reference

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Product Resources:

Copy of Technical Specifications

FeatureDetails
Viewing Head Siedentopf type trinocular head, inclined at 30°, Interpupillary adjustment 53mm to 75mm, graduated diopter on left eyetube (30mm I.D. eyetubes)
Eyepieces SWH10X Widefield high eyepoint eyepiece, Field No. 22, tube O.D. 30.0 mm
Nosepiece Quintuple
Quintuple LWD Planachromat Phase 10x, 20x
Condenser TC Condenser N.A. 0.30, W.D. 73.0mm
Stage180mm(X) x 245mm(Y) plain stage with replaceable glass insert with 45mm opening, Glass Stage plate insert
IlluminationKoehler without iris, with phase slider, 3W LED
WarrantyLIMITED LIFETIME WARRANTY

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