IGF‑1 Human Recombinant – Research Use Only

Scientific Overview

Insulin‑like Growth Factor‑1 (IGF‑1) is a key peptide growth factor involved in cellular proliferation, differentiation, survival, and metabolic regulation. Recombinant human IGF‑1 is widely used in cell biology, endocrinology, tissue engineering, and biochemical signaling studies due to its well‑characterized activity and conserved receptor interactions.

This recombinant IGF‑1 is produced to biotechnology‑grade purity and supplied as a stable powder suitable for reconstitution in aqueous buffers. Its small molecular size (7.8 kDa) and high bioactivity make it a valuable tool for investigating IGF‑1 receptor (IGF‑1R) signaling pathways, growth factor synergy, and downstream mechanisms involving PI3K/AKT, MAPK, and related cascades.

Common Research Applications

• Cell signaling and growth factor pathway studies
• IGF‑1 receptor activation assays
• Cell proliferation, differentiation, and survival experiments
• Tissue engineering and regenerative biology research
• Biochemical and molecular assays involving IGF‑1/IGFBP interactions
• Metabolic and endocrine research models

Usage & Handling Guidance

This product is supplied as a lyophilized powder. For experimental use, researchers typically reconstitute IGF‑1 in sterile water or dilute acid (e.g., 10 mM HCl) to improve solubility and stability. For long‑term use, aliquoting after reconstitution is recommended to avoid repeated freeze–thaw cycles.

• Reconstitution: Sterile water or dilute HCl (commonly 10 mM)
• Storage: −80 °C (powder); −20 °C to −80 °C for aliquots
• Handling: Avoid repeated freeze–thaw cycles

What You Get

• 50 µg recombinant human IGF‑1
• Biotechnology‑grade purity
• Stable powder form for flexible experimental use
• For research use only (RUO)

Frequently Asked Questions

• Is this product suitable for clinical or diagnostic use? No. This product is for research use only.
• Can I obtain a Certificate of Analysis (COA) or Technical Data Sheet (TDS)? COA and TDS availability depends on the manufacturer’s current active batch. In many cases, documentation can be provided upon request. Please contact us to inquire about documentation for the specific lot being shipped.
• What buffer should I use for reconstitution? Researchers commonly use sterile water or dilute HCl to improve solubility.
• Is IGF‑1 compatible with cell‑based assays? Yes. IGF‑1 is widely used in cell culture systems to stimulate growth factor signaling.

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References

• Junnila RK, List EO, Berryman DE, Murrey JW, Kopchick JJ. The GH/IGF-1 axis in ageing and longevity Nat Rev Endocrinol. 2013 Jun;9(6):366-376.
• Balhara B, Misra M, Levitsky LL. Recombinant human IGF-1 (insulin-like growth factor) therapy: where do we stand today? Indian J Pediatr. 2012 Feb;79(2):244-9.
• Backeljauw P. Therapy with recombinant human_IGF-1 for children with primary insulin-like growth factor-I deficiency Growth Horm IGF Res. 2020 Apr;51:22-26.
• Yan J, Charles JF. Gut Microbiota and IGF-1 Calcif Tissue Int. 2018 Apr;102(4):406-414.
• Poudel SB, Bhattarai G, Kook SH, Shin YJ, Kwon TH, Lee SY, Lee JC. Recombinant human_IGF-1 produced by transgenic plant cell suspension culture enhances new bone formation in calvarial defects Growth Horm IGF Res. 2017 Oct;36:1-10.
• Lu Z, Liu N, Huang H, Wang Y, Tu T, Qin X, Wang X, Zhang J, Su X, Tian J, Bai Y, Luo H, Yao B, Zhang H. Recombinant expression of IGF-1 and LR3 IGF-1 fused with xylanase in Pichia pastoris Appl Microbiol Biotechnol. 2023 Jul;107(14):4543-4551.
• Bou Khalil R. Recombinant human IGF-1 for patients with schizophrenia Med Hypotheses. 2011 Sep;77(3):427-9.
• Bright GM. Recombinant IGF-I: Past, present and future Growth Horm IGF Res. 2016 Jun;28:62-5.
• Lambrecht N. IGF-1/IGFBP-3 Serum Ratio as a Robust Measure to Determine GH Deficiency and Guide Human Recombinant GH Therapy J Clin Endocrinol Metab. 2023 Mar 10;108(4):e54-e55.