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Human Chorionic Gonadotropin Beta Core Fragment Proteins Molecular Depot
Human Chorionic Gonadotropin Beta Core Fragment Proteins Molecular Depot
Human Chorionic Gonadotropin Beta Core Fragment Proteins Molecular Depot
Human Chorionic Gonadotropin Beta Core Fragment Proteins Molecular Depot

Human Chorionic Gonadotropin Beta Core Fragment

$795.00

    Catalog Number: B2010655 (1 nmol)

    Human Chorionic Gonadotropin Beta Core Fragment is a lyophilized 1 nmol research-grade peptide derived from the degradation of hCG beta subunit. It is a critical reagent for the development, validation, and interference testing of hCG immunoassays used in pregnancy monitoring and cancer research. Ideal for studying hCG metabolism and urinary hCG variants. Custom Bulk quantities of this product are available on inquiry.

    Products are for in vitro research use only (RUO).

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Human Chorionic Gonadotropin Beta Core Fragment – Catalog #B2010655

Human Chorionic Gonadotropin Beta Core Fragment (Catalog #B2010655) is a lyophilized peptide supplied in 1 nmol quantities. The beta-core fragment (also known as hCGβcf or β-core) is a major urinary degradation product of human chorionic gonadotropin (hCG). It serves as an important research tool for the development and validation of hCG immunoassays, studies of hCG metabolism, pregnancy monitoring, and investigations into hCG-related cancers and assay interference.

Catalog number: B2010655
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 1 nmol
Molecular Weight or Concentration: N/A
Supplied as: Lyophilized
Applications: Development and validation of hCG immunoassays, studies of hCG metabolism and degradation, pregnancy biomarker research, cancer-related hCG studies, and assay interference evaluation
Storage: -20°C
Keywords: hCG Beta Core, hCG beta-core, hCGβcf, beta-core fragment
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

Scientific Overview

The beta-core fragment of human chorionic gonadotropin (hCGβcf) is a naturally occurring urinary degradation product formed by proteolytic cleavage of the hCG beta subunit. It is one of the most abundant hCG-related molecules in urine during pregnancy and certain malignancies. Because many commercial hCG assays cross-react with or are interfered by the beta-core fragment, it is an essential reagent for assay development, validation, interference studies, and research into hCG metabolism.

Key research applications include:

  • Development and standardization of hCG immunoassays
  • Evaluation of assay specificity and interference
  • Studies of hCG degradation pathways in pregnancy and cancer
  • Biomarker research in gestational trophoblastic disease and testicular cancer
  • Urinary hCG variant analysis

Usage & Handling Guidance

Store the lyophilized powder at -20°C. Reconstitute in sterile ultrapure water or PBS to the desired concentration. Prepare single-use aliquots to avoid repeated freeze–thaw cycles. Use protease-free conditions for long-term stability.

  • Recommended concentration: 0.1–1 nmol/mL working stocks (optimize for assay)
  • Stability: Lyophilized form is stable at -20°C; reconstituted solutions should be aliquoted and stored frozen
  • Applications: Spike-in controls for immunoassay validation and interference testing

What You Get

  • 1 nmol Human Chorionic Gonadotropin Beta Core Fragment as lyophilized powder
  • High-purity hCGβcf suitable for research and assay development
  • Biotechnology-grade material for sensitive immunoassay work
  • Convenient quantity for multiple experiments and method validation
  • For research use only (RUO)

Why Researchers Choose It

  • Authentic beta-core fragment for accurate hCG assay development and validation
  • Essential tool for studying hCG metabolism and urinary degradation products
  • Critical for evaluating assay interference in pregnancy and cancer diagnostics
  • High-purity lyophilized format with excellent stability
  • Widely referenced in hCG immunoassay and biomarker literature

Frequently Asked Questions (FAQ)

  • What is the hCG beta-core fragment?
    It is a proteolytic degradation product of the hCG beta subunit commonly found in urine during pregnancy and certain cancers.
  • Why is this fragment important?
    Many hCG immunoassays cross-react with or are interfered by β-core, making it essential for assay validation and interference testing.
  • How should I reconstitute the product?
    Dissolve in sterile ultrapure water or PBS to the desired concentration. Aliquot and store at -20°C.
  • Is this suitable for immunoassay development?
    Yes. It is widely used as a standard and interference control in hCG assay research.
  • What storage conditions are recommended?
    Store lyophilized powder at -20°C for long-term stability.
This product is for Research Use Only (RUO). It is not intended for diagnostic or therapeutic use in humans or animals.

References

  • Schutter EM, Mulder C, van Kamp GJ, Kenemans P. The beta-core fragment of human chorionic gonadotropin: biochemical background and clinical application. Anticancer Res. 1997 Mar-Apr;17(2B):1255-72.
  • Stenman UH, Alfthan H. Determination of human chorionic gonadotropin. Best Pract Res Clin Endocrinol Metab. 2013 Dec;27(6):783-93. Reference
  • Okamoto T. [Human chorionic gonadotropin beta-core fragment (hCGbetacf)]. Nihon Rinsho. 2005 Aug;63 Suppl 8:765-7.
  • Hoermann R, Spoettl G, Berger P, Mann K. Immunoreactive human chorionic gonadotropin beta core fragment in human pituitary. Exp Clin Endocrinol Diabetes. 1995;103(5):324-31. Reference
  • Okamoto T. [Human chorionic gonadotropin beta-core fragment (hCG beta-cf)]. Nihon Rinsho. 1999 Dec;57 Suppl:586-8.
  • Montagnana M, Trenti T, Aloe R, Cervellin G, Lippi G. Human chorionic gonadotropin in pregnancy diagnostics. Clin Chim Acta. 2011 Aug 17;412(17-18):1515-20. Reference
  • Johnson S, Marriott L, Yang HT, Grenache DG. Testing for negative interference from beta-core fragment hCG in urine. J Appl Lab Med. 2021 Nov 1;6(6):1695-1697. Reference
  • Bahado-Singh RO, Oz U, Isozaki T, Seli E, Kovanci E, Hsu CD, Cole L. Midtrimester urine human chorionic gonadotropin beta-subunit core fragment levels and the subsequent development of pre-eclampsia. Am J Obstet Gynecol. 1998 Sep;179(3 Pt 1):738-41. Reference
  • Cole LA, Laidler LL. Inherited human chorionic gonadotropin. J Reprod Med. 2010 Mar-Apr;55(3-4):99-102.
  • Papapetrou PD, Nicopoulou SC. The origin of a human chorionic gonadotropin beta-subunit-core fragment excreted in the urine of patients with cancer. Acta Endocrinol (Copenh). 1986 Jul;112(3):415-22.

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FeatureDetails
Viewing Head Siedentopf type trinocular head, inclined at 30°, Interpupillary adjustment 53mm to 75mm, graduated diopter on left eyetube (30mm I.D. eyetubes)
Eyepieces SWH10X Widefield high eyepoint eyepiece, Field No. 22, tube O.D. 30.0 mm
Nosepiece Quintuple
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Stage180mm(X) x 245mm(Y) plain stage with replaceable glass insert with 45mm opening, Glass Stage plate insert
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WarrantyLIMITED LIFETIME WARRANTY

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