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DSPE PEG(2000)-N-Cy5.5 Chemicals Molecular Depot
DSPE PEG(2000)-N-Cy5.5 Chemicals Molecular Depot
DSPE PEG(2000)-N-Cy5.5 Chemicals Molecular Depot
DSPE PEG(2000)-N-Cy5.5 Chemicals Molecular Depot

DSPE PEG(2000)-N-Cy5.5

$1,095.00

    Catalog Number: B2018859 (1 mg)

    DSPE PEG(2000)-N-Cy5.5 is a conjugate of a phospholipid, a PEG spacer, and a fluorescent dye. This compound aids in the development of liposomal systems, enhancing solubility and enabling tracking in biological systems. This product has been used as a molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request.

    Products are for in vitro research use only (RUO).

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DSPE-PEG(2000)-N-Cy5.5 – Catalog #B2018859 (1 mg)

Catalog # B2018859
Lot # Batch dependent
Expiration Batch dependent
Amount 1 mg
Molecular Weight 3,338 g/mol
Supplied As Powder
Applications Biochemical research, liposomal tracking, solubility enhancement
Storage –20 °C
Keywords DSPE-PEG(2000)-N-Cy5.5, 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[amino(polyethylene glycol)-2000]-N-(Cyanine 5.5)
Grade Biotechnology grade; highly pure; made with Type I ultrapure water (>18 MΩ·cm) and filtered through 0.22 µm

DSPE-PEG(2000)-N-Cy5.5 is a high-performance fluorescent lipid conjugate combining DSPE, a PEG(2000) spacer for steric stabilization, and Cy5.5 dye for robust near-infrared imaging and tracking applications. This powder (Catalog #B2018859, 1 mg; MW 3,338 g/mol) is optimized for incorporation into liposomal systems, micelles, and other lipid-based carriers to enhance solubility and enable real-time visualization in biological environments. Its amphiphilic architecture ensures integration into lipid bilayers while the PEG spacer imparts surface stealth characteristics, and the Cy5.5 tag enables sensitive detection in bioimaging workflows.

Crafted to biotechnology-grade purity, DSPE-PEG(2000)-N-Cy5.5 enables reproducible performance in drug delivery, nanoparticle tracking, and biodistribution studies. It helps researchers monitor liposome trafficking, assess circulation dynamics, and quantify delivery vehicle uptake with high contrast and minimal background autofluorescence. Custom bulk quantities are available to accommodate preclinical studies and serial imaging. Packaged as a stable powder and stored at –20 °C, it maintains consistent activity across multiple experimental cycles.

Why researchers choose this product:

  • Conjugates lipophilic anchor (DSPE) with stealth PEG spacing and near-IR Cy5.5 label
  • Superior integration into liposomal and micellar delivery vehicles for imaging and tracking
  • Near-infrared detection minimizes background interference and improves tissue penetration
  • Biotech-grade purity ensures consistency in formulation and experimental outcomes
  • Available in bulk for extended preclinical and translational studies

Indication for Use:
This product is for Research Use Only (RUO). It is not intended for diagnostic, therapeutic, or clinical use.

References:

  • 1: Bai J, Zhou Z, Tang H, Song S, Peng J, Xu Y. Impact of PEGylation on biodistribution and tumor accumulation of Lipid-Mu peptide-DNA. J Liposome Res. 2013 Mar;23(1):1-10.
  • 2: Song XL, Liu S, Jiang Y, Gu LY, Xiao Y, Wang X, Cheng L, Li XT. Targeting vincristine plus tetrandrine liposomes modified with DSPE-PEG(2000)-transferrin in treatment of brain glioma. Eur J Pharm Sci. 2017 Jan 1;96:129-140.
  • 3: Wu H, Zhu L, Torchilin VP. pH-sensitive poly(histidine)-PEG/DSPE-PEG co-polymer micelles for cytosolic drug delivery. Biomaterials. 2013 Jan;34(4):1213-22.
  • 4: Gill KK, Kaddoumi A, Nazzal S. Mixed micelles of PEG(2000)-DSPE and vitamin-E TPGS for concurrent delivery of paclitaxel and parthenolide: enhanced chemosensitization and antitumor efficacy against non-small cell lung cancer (NSCLC) cell lines. Eur J Pharm Sci. 2012 May 12;46(1-2):64-71.
  • 5: de Souza Guimarães M, Cachumba JJM, Bueno CZ, Torres-Obreque KM, Lara GVR, Monteiro G, Barbosa LRS, Pessoa A Jr, Rangel-Yagui CO. Peg-Grafted Liposomes for L-Asparaginase Encapsulation. Pharmaceutics. 2022 Aug 29;14(9):1819.
  • 6: Chen Z, Higashi K, Shidara R, Ueda K, Morita T, Limwikrant W, Yamamoto K, Moribe K. The nanostructure of rod-like ascorbyl dipalmitate nanoparticles stabilized by a small amount of DSPE-PEG. Int J Pharm. 2021 Jun 1;602:120599.
  • 7: Sandström MC, Johansson E, Edwards K. Influence of preparation path on the formation of discs and threadlike micelles in DSPE-PEG(2000)/lipid systems. Biophys Chem. 2008 Feb;132(2-3):97-103.
  • 8: Kastantin M, Ananthanarayanan B, Karmali P, Ruoslahti E, Tirrell M. Effect of the lipid chain melting transition on the stability of DSPE-PEG(2000) micelles. Langmuir. 2009 Jul 7;25(13):7279-86.
  • 9: Higashi K, Mibu F, Saito K, Limwikrant W, Yamamoto K, Moribe K. Composition-dependent structural changes and antitumor activity of ASC-DP/DSPE-PEG nanoparticles. Eur J Pharm Sci. 2017 Mar 1;99:24-31.
  • 10: Wang D, Wang Y, Zhao G, Zhuang J, Wu W. Improving systemic circulation of paclitaxel nanocrystals by surface hybridization of DSPE-PEG2000. Colloids Surf B Biointerfaces. 2019 Oct 1;182:110337.

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Product Resources:

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Copy of Technical Specifications

FeatureDetails
Viewing Head Siedentopf type trinocular head, inclined at 30°, Interpupillary adjustment 53mm to 75mm, graduated diopter on left eyetube (30mm I.D. eyetubes)
Eyepieces SWH10X Widefield high eyepoint eyepiece, Field No. 22, tube O.D. 30.0 mm
Nosepiece Quintuple
Quintuple LWD Planachromat Phase 10x, 20x
Condenser TC Condenser N.A. 0.30, W.D. 73.0mm
Stage180mm(X) x 245mm(Y) plain stage with replaceable glass insert with 45mm opening, Glass Stage plate insert
IlluminationKoehler without iris, with phase slider, 3W LED
WarrantyLIMITED LIFETIME WARRANTY

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