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CDK5 Substrate - (5-TMR) labeled Chemicals Molecular Depot
CDK5 Substrate - (5-TMR) labeled Chemicals Molecular Depot
CDK5 Substrate - (5-TMR) labeled Chemicals Molecular Depot
CDK5 Substrate - (5-TMR) labeled Chemicals Molecular Depot

CDK5 Substrate - (5-TMR) labeled

$795.00

    Catalog Number: B2019514 (1 mg)

    CDK5 (Cyclin-Dependent Kinase 5) is a serine/threonine kinase crucial for neuronal development and function. It is primarily active in post-mitotic neurons and does not require a cyclin for activation. A CDK5 substrate labeled with 5-TMR is phosphorylated by CDK5 and tagged with a fluorescent dye for visualization in experimental settings. This product has been used as a molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request.

    Products are for in vitro research use only (RUO).

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What's Included

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VR Headset

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2 Touch Controllers

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Charging Cable

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Power Adapter

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Glasses Spacer

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CDK5 Substrate - (5-TMR) labeled

Catalog number: B2019514
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 1 mg
Molecular Weight or Concentration: 1551
Supplied as: Powder
Applications: a molecular tool for various biochemical applications
Storage: -20°C
Keywords: 5-TMR-PKTPKKAKKL
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References

  • He Y, Pan S, Xu M, He R, Huang W, Song P, Huang J, Zhang HT, Hu Y. Adeno-associated virus 9-mediated Cdk5 inhibitory peptide reverses pathologic changes and behavioral deficits in the Alzheimer’s disease mouse model FASEB J. 2017 Aug;31(8):3383-3392.
  • Su SC, Seo J, Pan JQ, Samuels BA, Rudenko A, Ericsson M, Neve RL, Yue DT, Tsai LH. Regulation of N-type voltage-gated calcium channels and presynaptic function by cyclin-dependent kinase 5 Neuron. 2012 Aug 23;75(4):675-87.
  • Cho DH, Seo J, Park JH, Jo C, Choi YJ, Soh JW, Jo I. Cyclin-dependent kinase 5 phosphorylates endothelial nitric oxide synthase at serine 116 Hypertension. 2010 Feb;55(2):345-52.
  • Cruz JC, Tseng HC, Goldman JA, Shih H, Tsai LH. Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles Neuron. 2003 Oct 30;40(3):471-83.
  • Nguyen MD, Larivière RC, Julien JP. Deregulation of Cdk5 in a mouse model of ALS: toxicity alleviated by perikaryal neurofilament inclusions Neuron. 2001 Apr;30(1):135-47.
  • Seeburg DP, Feliu-Mojer M, Gaiottino J, Pak DT, Sheng M. Critical role of CDK5 and Polo-like kinase 2 in homeostatic synaptic plasticity during elevated activity Neuron. 2008 May 22;58(4):571-83.
  • Zambrano CA, Egaña JT, Núñez MT, Maccioni RB, González-Billault C. Oxidative stress promotes tau dephosphorylation in neuronal cells: the roles of cdk5 and PP1 Free Radic Biol Med. 2004 Jun 1;36(11):1393-402.
  • Cazares VA, Njus MM, Manly A, Saldate JJ, Subramani A, Ben-Simon Y, Sutton MA, Ashery U, Stuenkel EL. Dynamic Partitioning of Synaptic Vesicle Pools by the SNARE-Binding Protein Tomosyn J Neurosci. 2016 Nov 2;36(44):11208-11222.
  • Yeh CW, Hsu LS. Zebrafish diras1 Promoted Neurite Outgrowth in Neuro-2a Cells and Maintained Trigeminal Ganglion Neurons In Vivo via Rac1-Dependent Pathway Mol Neurobiol. 2016 Dec;53(10):6594-6607.

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Product Resources:

Copy of Technical Specifications

FeatureDetails
Viewing Head Siedentopf type trinocular head, inclined at 30°, Interpupillary adjustment 53mm to 75mm, graduated diopter on left eyetube (30mm I.D. eyetubes)
Eyepieces SWH10X Widefield high eyepoint eyepiece, Field No. 22, tube O.D. 30.0 mm
Nosepiece Quintuple
Quintuple LWD Planachromat Phase 10x, 20x
Condenser TC Condenser N.A. 0.30, W.D. 73.0mm
Stage180mm(X) x 245mm(Y) plain stage with replaceable glass insert with 45mm opening, Glass Stage plate insert
IlluminationKoehler without iris, with phase slider, 3W LED
WarrantyLIMITED LIFETIME WARRANTY

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