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ACO2 Antibody (Center), Rabbit Polyclonal Antibodies Molecular Depot
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ACO2 Antibody (Center), Rabbit Polyclonal Antibodies Molecular Depot
Anti-GFP Magnetic Beads Beads & Particles Molecular Depot

ACO2 Antibody (Center), Rabbit Polyclonal

$825.00

    Catalog Number: L2001509 (100 µg)

    ACO2 Antibody (Center) (Catalog #L2001509) is a rabbit polyclonal IgG raised against a KLH-conjugated synthetic peptide from the central region (aa 438–467) of human ACO2, the mitochondrial aconitase of the TCA cycle. It reacts with human and rat ACO2 and is suited to Western blot and IHC on paraffin sections, supporting research on mitochondrial metabolism, oxidative stress, and ACO2-related neurodegeneration. Supplied as 100 µg in PBS with 0.09% sodium azide. Custom bulk amounts are available upon request.

    Products are for in vitro research use only (RUO).

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ACO2 Antibody (Center), Rabbit Polyclonal – Catalog #L2001509

ACO2 Antibody (Center) (Catalog #L2001509) is a purified rabbit polyclonal antibody against aconitate hydratase, mitochondrial (ACO2). It was generated by immunizing rabbits with a KLH-conjugated synthetic peptide corresponding to amino acids 438–467 in the central region of human ACO2, and is supplied as 100 µg in PBS with 0.09% (w/v) sodium azide. The antibody reacts with human and rat ACO2 and is suitable for Western blotting (WB) and immunohistochemistry on paraffin-embedded sections (IHC-P).

Catalog number: L2001509
Lot number: Batch dependent
Expiration Date: Batch dependent
Amount: 100 µg
Concentration: 0.25–0.5 mg/mL
Host / Clonality: Rabbit / Polyclonal
Isotype: IgG
Immunogen: KLH-conjugated synthetic peptide, aa 438–467 (central region) of human ACO2
Species reactivity: Human, Rat
Applications: Western blot (WB), immunohistochemistry – paraffin (IHC-P)
Purification: Saturated ammonium sulfate (SAS) precipitation followed by dialysis against PBS
Supplied as: Solution in PBS with 0.09% (w/v) sodium azide
Target: ACO2 (aconitate hydratase, mitochondrial; UniProt Q99798; EC 4.2.1.3)
Storage: −20°C
Keywords: ACO2 antibody, anti-ACO2, mitochondrial aconitase antibody, aconitate hydratase mitochondrial, aconitase 2, citrate hydro-lyase, EC 4.2.1.3, rabbit polyclonal ACO2
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

Scientific Overview

ACO2 encodes mitochondrial aconitase (aconitate hydratase), the second enzyme of the tricarboxylic acid (TCA) cycle, which catalyzes the stereospecific isomerization of citrate to isocitrate. The enzyme contains an iron–sulfur cluster that is sensitive to oxidative damage, so ACO2 abundance and activity are frequently examined in studies of mitochondrial function and oxidative stress.

ACO2 is located on chromosome 22q13.2. Biallelic pathogenic variants cause infantile cerebellar-retinal degeneration (ICRD) and have also been linked to optic atrophy, making ACO2 a target of interest in mitochondrial disease and neurodegeneration research.

Key applications include:

  • Detecting ACO2 protein levels by Western blot in human and rat samples
  • Localizing ACO2 in paraffin-embedded tissue by IHC
  • Mitochondrial metabolism and TCA cycle research
  • Oxidative stress and mitochondrial disease studies

Usage & Handling Guidance

Store at −20°C. Aliquot on first thaw to avoid repeated freeze–thaw cycles, and centrifuge briefly before opening. Optimal working dilutions should be determined by the end user for each application; request the datasheet for starting recommendations.

  • Sodium azide: Contains 0.09% sodium azide, which inhibits horseradish peroxidase. Keep azide out of HRP detection steps and handle with appropriate care.
  • Controls: Include a positive-control lysate or tissue with known ACO2 expression when establishing conditions.

What You Get

  • 100 µg of purified rabbit polyclonal anti-ACO2 antibody
  • Supplied at 0.25–0.5 mg/mL in PBS with 0.09% sodium azide
  • Reactivity with human and rat ACO2
  • For research use only (RUO)

Why Researchers Choose It

  • Defined immunogen from the central region (aa 438–467) of human ACO2
  • Suitable for both Western blot and IHC-P
  • Cross-species reactivity with human and rat
  • Targets a key enzyme in mitochondrial and TCA cycle research

Frequently Asked Questions (FAQ)

  • What does this antibody detect?
    Human and rat ACO2 (mitochondrial aconitase), the TCA-cycle enzyme that converts citrate to isocitrate.
  • Which applications is it suitable for?
    Western blot and immunohistochemistry on paraffin-embedded sections.
  • Is a monoclonal version available?
    Yes. Catalog #L2001206 is a mouse monoclonal IgG1 anti-ACO2 antibody reactive with human ACO2 for Western blot.
  • What dilution should I use?
    Optimal dilutions depend on your sample and detection system. Titrate for each application and request the datasheet for starting points.
  • How should I store it?
    At −20°C in aliquots, avoiding repeated freeze–thaw cycles.
This product is for Research Use Only (RUO). It is not intended for diagnostic or therapeutic use in humans or animals.

References

  • Spiegel R, Pines O, Ta-Shma A, Burak E, Shaag A, Halvardson J, Edvardson S, Mahajna M, Zenvirt S, Saada A, Shalev S, Feuk L, Elpeleg O. Infantile cerebellar-retinal degeneration associated with a mutation in mitochondrial aconitase, ACO2. Am J Hum Genet. 2012;90(3):518-523.Reference
  • Metodiev MD, Gerber S, Hubert L, Delahodde A, Chretien D, Gérard X, Amati-Bonneau P, Giacomotto MC, Boddaert N, Kaminska A, Desguerre I, Amiel J, Rio M, Kaplan J, Munnich A, Rötig A, Rozet JM, Besmond C. Mutations in the tricarboxylic acid cycle enzyme, aconitase 2, cause either isolated or syndromic optic neuropathy with encephalopathy and cerebellar atrophy. J Med Genet. 2014;51(12):834-838.Reference

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