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Nervonic Acid (Highly Pure) Chemicals Molecular Depot
Nervonic Acid (Highly Pure) Chemicals Molecular Depot
Nervonic Acid (Highly Pure) Chemicals Molecular Depot
Nervonic Acid (Highly Pure) Chemicals Molecular Depot

Nervonic Acid (Highly Pure)

$695.00

    Catalog Number: B2017583 (50 mg)

    Nervonic acid is a type of long-chain monounsaturated fatty acid. It is a a 50 mg high-purity very-long-chain fatty acid (cis-15-tetracosenoic acid, C24:1 n-9, MW 366.62 g/mol) supplied as a powder. This key component of brain sphingolipids and myelin is widely used in neurobiology, lipid metabolism, myelination, and sphingolipid research. Ideal for studies on nerve repair, membrane fluidity, and neurological disorders. Custom bulk amounts of this product are available upon request.

    Products are for in vitro research use only (RUO).

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Nervonic Acid (Highly Pure) – Research Use Only

Nervonic Acid (cis-15-Tetracosenoic acid, Selacholeic acid) is a long-chain monounsaturated fatty acid (C24:1 n-9) supplied as a 50 mg high-purity powder (Catalog #B2017583, MW 366.62 g/mol). This biotechnology-grade fatty acid is a key component of brain sphingolipids (especially nervonyl-sphingomyelin) and plays important roles in myelination, nerve repair, and membrane fluidity. It is widely used in neurobiology, lipid metabolism, and sphingolipid research.

Catalog number: B2017583
Lot number: Batch dependent
Expiration Date: Batch dependent
Amount: 50 mg
Molecular Weight or Concentration: 366.62 g/mol
Supplied as: POWDER
Applications: Neurobiology research, sphingolipid metabolism, myelination studies, nerve repair, membrane fluidity, and lipidomics
Storage: -20 °C
Keywords: cis-15-Tetracosenoic acid, Selacholeic acid
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

Scientific Overview

Nervonic Acid (24:1 n-9) is a very long-chain monounsaturated fatty acid that is a major constituent of sphingolipids in the brain white matter and myelin sheath. It is critical for myelination during brain development and for maintaining nerve conduction velocity. Deficiencies or imbalances in nervonic acid have been linked to demyelinating disorders, adrenoleukodystrophy, and certain neurological conditions. As a research reagent, it is used to study sphingolipid biosynthesis, membrane properties, and potential therapeutic roles in neuroprotection and myelin repair.

This Nervonic Acid (Highly Pure) is suitable for:

  • Studies on myelin formation and nerve myelination
  • Sphingolipid metabolism and lipidomics research
  • Investigation of very-long-chain fatty acid functions in the nervous system
  • Membrane fluidity and lipid raft studies
  • Neurodegenerative disease models and potential supplementation research

Usage & Handling Guidance

Store the powder at -20 °C. Reconstitute in organic solvents (e.g., chloroform, ethanol, or DMSO) to prepare stock solutions. For cell culture or biochemical assays, dilute into appropriate aqueous buffers containing carriers (e.g., BSA or cyclodextrins) to improve solubility. Prepare fresh working solutions as needed.

  • Recommended applications: Lipid metabolism, neurobiology, and sphingolipid studies
  • Working concentration: Typically 10–100 µM (optimize for specific assay)
  • Solubility: Soluble in organic solvents; limited aqueous solubility without carriers
  • Handling: Protect from light and oxidation; use inert atmosphere if storing solutions long-term

What You Get

  • 50 mg Nervonic Acid (Highly Pure) as a powder
  • cis-15-Tetracosenoic acid (C24:1 n-9, MW 366.62 g/mol)
  • Biotechnology-grade fatty acid suitable for sensitive lipid research
  • Convenient quantity for multiple experiments
  • For research use only (RUO)

Why Researchers Choose It

  • High-purity nervonic acid for accurate lipid metabolism and neurobiology studies
  • Key component of brain sphingolipids and myelin sheath
  • Important for research on myelination, nerve repair, and neurodegenerative conditions
  • Stable powder format with reliable quality
  • Well-documented roles in membrane structure and signaling

Frequently Asked Questions (FAQ)

  • What is the biological importance of nervonic acid?
    It is a major fatty acid in brain sphingolipids and myelin, essential for proper myelination and nerve function.
  • How should I dissolve the powder?
    Dissolve in chloroform, ethanol, or DMSO to make stock solutions. For aqueous use, incorporate into buffers with BSA or other carriers.
  • What is the typical working concentration?
    Usually 10–100 µM in cell culture or biochemical assays (optimize for your system).
  • Is this suitable for cell culture?
    Yes, when properly solubilized and used at non-toxic concentrations.
  • How should I store the product?
    Store at -20 °C to maintain stability.
This product is for Research Use Only (RUO). It is not intended for diagnostic or therapeutic use in humans or animals.

References

  • Phung NV, Rong F, Xia WY, Fan Y, Li XY, Wang SA, Li FL. Nervonic acid and its sphingolipids: Biological functions and potential food applications. Crit Rev Food Sci Nutr. 2023 Apr 28:1-20. Reference
  • Giwa AS, Ali N. Perspectives of nervonic acid production by Yarrowia lipolytica. Biotechnol Lett. 2022 Feb;44(2):193-202. Reference
  • Yuan SN, Wang MX, Han JL, Feng CY, Wang M, Wang M, Sun JY, Li NY, Simal-Gandara J, Liu C. Improved colonic inflammation by nervonic acid via inhibition of NF-κB signaling pathway of DSS-induced colitis mice. Phytomedicine. 2023 Apr;112:154702. Reference
  • Fan Y, Meng HM, Hu GR, Li FL. Biosynthesis of nervonic acid and perspectives for its production by microalgae and other microorganisms. Appl Microbiol Biotechnol. 2018 Apr;102(7):3027-3035. Reference
  • Liu F, Wu R, Ma X, Su E. The Advancements and Prospects of Nervonic Acid Production. J Agric Food Chem. 2022 Oct 12;70(40):12772-12783. Reference
  • Ling C, Li F, Zhao J, Wen M, Han X. Research Progress of Nervonic Acid Biosynthesis. J Oleo Sci. 2023 Oct 3;72(10):889-900. Reference
  • Li Q, Chen J, Yu X, Gao JM. A mini review of nervonic acid: Source, production, and biological functions. Food Chem. 2019 Dec 15;301:125286. Reference
  • Keppley LJW, Walker SJ, Gademsey AN, Smith JP, Keller SR, Kester M, Fox TE. Nervonic acid limits weight gain in a mouse model of diet-induced obesity. FASEB J. 2020 Nov;34(11):15314-15326. Reference
  • Wang X, Liang T, Mao Y, Li Z, Li X, Zhu X, Cao F, Zhang J. Nervonic acid improves liver inflammation in a mouse model of Parkinson’s disease by inhibiting proinflammatory signaling pathways and regulating metabolic pathways. Phytomedicine. 2023 Aug;117:154911. Reference
  • Terluk MR, Tieu J, Sahasrabudhe SA, Moser A, Watkins PA, Raymond GV, Kartha RV. Nervonic Acid Attenuates Accumulation of Very Long-Chain Fatty Acids and is a Potential Therapy for Adrenoleukodystrophy. Neurotherapeutics. 2022 Apr;19(3):1007-1017. Reference

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Copy of Technical Specifications

FeatureDetails
Viewing Head Siedentopf type trinocular head, inclined at 30°, Interpupillary adjustment 53mm to 75mm, graduated diopter on left eyetube (30mm I.D. eyetubes)
Eyepieces SWH10X Widefield high eyepoint eyepiece, Field No. 22, tube O.D. 30.0 mm
Nosepiece Quintuple
Quintuple LWD Planachromat Phase 10x, 20x
Condenser TC Condenser N.A. 0.30, W.D. 73.0mm
Stage180mm(X) x 245mm(Y) plain stage with replaceable glass insert with 45mm opening, Glass Stage plate insert
IlluminationKoehler without iris, with phase slider, 3W LED
WarrantyLIMITED LIFETIME WARRANTY

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