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Epoxy Magnetic Beads (1 µm) Beads & Particles Molecular Depot
KRAS G12D Peptide (VVVGADGVGK) Beads & Particles Molecular Depot
Epoxy Magnetic Beads (1 µm) Beads & Particles Molecular Depot
KRAS G12D Peptide (VVVGADGVGK) Beads & Particles Molecular Depot

Epoxy Magnetic Beads (1 µm)

$585.00

    Catalog Number: B2025679 (1 mL)

    Epoxy Magnetic Beads (1 µm; Catalog #B2025679) are small, superparamagnetic particles with reactive epoxy groups for stable covalent coupling of proteins, antibodies, and ligands. Supplied as 1 mL suspension, these 1-micrometer beads enable rapid affinity capture, immunoassays, immunoprecipitation, and protein purification applications. Their small size provides high surface area for efficient binding, while magnetic properties allow easy separation using a magnet. Custom bulk amounts of this product are available upon request.

    Products are for in vitro research use only (RUO).

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Epoxy Magnetic Beads (1 µm) – Catalog #B2025679

Epoxy Magnetic Beads (1 µm; Catalog #B2025679) are superparamagnetic particles functionalized with epoxy groups that form stable covalent bonds with lysine residues of proteins and ligands. Supplied as a 1 mL suspension, these 1-micrometer beads combine the reactivity of epoxy chemistry with the convenience of magnetic separation, enabling rapid sample processing and high recovery in affinity-based applications.

Catalog number: B2025679
Lot number: Batch dependent
Expiration Date: Batch dependent
Amount: 1 mL
Bead size: 1 µm
Supplied as: Suspension
Storage: 2–8°C
Applications: Affinity capture, immunoassays, immunoprecipitation, protein purification, antibody coupling
Keywords: epoxy magnetic beads, magnetic particles, affinity beads, protein coupling beads, immunomagnetic beads, epoxy-functionalized beads, superparamagnetic beads
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

Scientific Overview

Epoxy-functionalized magnetic beads are widely used for immunoassays and affinity purification because epoxy groups form stable, covalent bonds with primary amines (lysine and N-terminal residues) on proteins and ligands. The superparamagnetic iron oxide core allows beads to be rapidly separated from solution using a magnet, without requiring centrifugation. At 1 µm, these beads offer a favorable balance: large enough for efficient magnetic capture, small enough to provide high surface area and rapid diffusion kinetics.

Key applications include:

  • Covalent coupling of antibodies, enzymes, and affinity ligands
  • Immunomagnetic separation and immunoprecipitation
  • Protein purification and sample preparation
  • High-throughput immunoassays and bead-based diagnostics
  • Affinity enrichment of target molecules from complex samples

Usage & Handling Guidance

Store at 2–8°C; shake gently before use to ensure homogeneous suspension. Epoxy groups react with primary amines under slightly alkaline conditions (pH 8–10). Optimize pH and temperature for coupling (typically room temperature to 4°C overnight). After coupling, incubate unused epoxy groups with an amine buffer (e.g., ethanolamine or glycine) to reduce nonspecific binding.

  • Coupling protocol: Incubate beads with your protein or ligand at pH 8–10 for 2–16 hours; coupling efficiency depends on amine concentration and pH.
  • Blocking: Quench remaining epoxy groups with a blocking amine to reduce nonspecific binding.
  • Washing: Wash beads magnetically using a magnet to retain beads while removing solution.
  • Storage: Store coupled beads at 2–8°C; refer to your blocking and storage buffer for optimal stability.

What You Get

  • 1 mL suspension of 1 µm epoxy magnetic beads
  • Reactive epoxy groups for direct protein coupling
  • Magnetic core for rapid separation without centrifugation
  • For research use only (RUO)

Why Researchers Choose It

  • Stable covalent bonds reduce nonspecific binding compared to passive adsorption
  • 1 µm size balances surface area with efficient magnetic separation
  • Direct coupling of antibodies, enzymes, and ligands without intermediate linkers
  • High recovery and minimal sample loss in magnetic separation workflows

Frequently Asked Questions (FAQ)

  • How do epoxy beads differ from carboxyl- or amino-functionalized beads?
    Epoxy groups react with amines to form stable secondary amines (not reversible), whereas carboxyl or amino beads often use intermediate linkers or salt-dependent binding.
  • What is the optimal pH for coupling?
    pH 8–10 is typical; the exact pH depends on your protein and buffer. Request a COA/TDS for lot-specific recommendations.
  • How long does coupling take?
    Typically 2–16 hours at room temperature or 4°C, depending on amine concentration and pH.
  • Can I reuse the beads?
    Once a protein is covalently coupled, the beads are generally not reusable. Plan quantities accordingly.
  • How do I prevent nonspecific binding?
    Block unused epoxy groups with a primary amine (glycine or ethanolamine) and use appropriate washing buffers to reduce nonspecific adsorption.
This product is for Research Use Only (RUO). It is not intended for diagnostic or therapeutic use in humans or animals.

References

  • Cao R, Xu S, Yu Z, Xu L, Ge Z, Huo Q, Zhu G, Qiao B. Integration of protein L-immobilized epoxy magnetic bead capture with LC-MS/MS for therapeutic monoclonal antibody quantification in serum. Anal Methods. 2024;16(23):3720-3731.Reference
  • Haukanes BI, Kvam C. Application of magnetic beads in bioassays. Biotechnology (N Y). 1993;11(1):60-3.Reference
  • Zhu G, Walter JG. Aptamer-modified magnetic beads in affinity separation of proteins. Methods Mol Biol. 2015;1286:67-82.Reference

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