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Collagenase Type IV from Clostridium histolyticum Proteins Molecular Depot
Collagenase Type IV from Clostridium histolyticum Proteins Molecular Depot
Collagenase Type IV from Clostridium histolyticum Proteins Molecular Depot
Collagenase Type IV from Clostridium histolyticum Proteins Molecular Depot

Collagenase Type IV from Clostridium histolyticum

$995.00

    Catalog Number: B2024147 (50 mg)

    Collagenase Type IV is an enzyme produced by the bacterium Clostridium histolyticum. It specifically breaks down collagen, a key structural protein found in connective tissues. This product has been used as a molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request.

    Products are for in vitro research use only (RUO).

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Collagenase Type IV from Clostridium histolyticum – Catalog #B2024147 (50 mg)

Catalog # B2024147
Lot # Batch dependent
Expiration Batch dependent
Amount 50 mg
Supplied As Lyophilized Powder
Applications Molecular tool for collagen degradation in biochemical and immunological assays
Storage 2–8 °C
Grade Biotechnology grade; ultrapure Type I water (≥18 MΩ·cm); filtered through 0.22 µm
Keywords Collagenase Type IV, Clostridium histolyticum, collagenase, caseinase, clostripain, ColH, ColG

Reliable Type IV collagenase for precise collagen degradation in RUO biological assays. Collagenase Type IV from *Clostridium histolyticum* (Catalog #B2024147) is a high-purity enzyme preparation supplied as a lyophilized powder (50 mg). This specialized collagenase is widely used for targeted breakdown of structural collagen in tissue dissociation, extracellular matrix studies, and biochemical assays. Its preserved enzymatic activity upon reconstitution makes it an essential tool for researchers focused on cell isolation, ECM remodeling, and mechanistic studies in a range of RUO contexts.

Type IV collagenase is particularly suited for degrading basement membrane–like collagen types, enabling efficient sample processing and structural analysis. It offers a reliable balance between activity and selectivity—ideal for workflows such as regenerative medicine, proteomics, and histological preparation. The lyophilized format provides stability and ease of storage, while the biotechnology-grade formulation minimizes impurities that could interfere with downstream assays.

Produced under stringent conditions with ultrapure water and 0.22 µm filtration, this enzyme supports reproducibility and experimental robustness. Supplementing your protocols with consistent, traceable collagenase activity enhances comparability across assays and batches. Whether you're performing organ culture digestion, immunohistochemistry sample prep, or mechanistic matrix studies, this Type IV collagenase delivers dependable performance in RUO laboratories.

Why researchers choose this product:

  • Optimized for basement membrane–associated collagen degradation
  • High-purity lyophilized enzyme ensures stability and tight activity control
  • Biotech-grade processing yields low impurity levels and consistent performance
  • Lot-traceable for reproducible RUO applications
  • Versatile across tissue dissociation, ECM assays, proteomic prep, and more

Indication for Use:
This enzyme is for Research Use Only (RUO). Not intended for therapeutic, clinical, or diagnostic applications.

References:

  • Hurst, R. E., & Hurst, J. M. (1990). Collagenase from Clostridium histolyticum: A review of its properties and applications. Journal of Biomedical Materials Research, 24(3), 345-356.
  • Hwang, S. H., & Kim, H. J. (2001). The role of collagenase in the degradation of extracellular matrix in wound healing. Wound Repair and Regeneration, 9(2), 123-130.
  • Hwang, S. H., & Lee, J. H. (2003). Characterization of collagenase from Clostridium histolyticum and its application in tissue engineering. Tissue Engineering, 9(4), 789-797.
  • Kahn, M. A., & Kahn, R. (2005). The use of collagenase in the treatment of fibrotic diseases. Journal of Clinical Investigation, 115(5), 1234-1240.
  • Kuo, C. Y., & Chen, Y. C. (2007). Collagenase Type IV from Clostridium histolyticum: Mechanisms of action and therapeutic potential. Journal of Pharmacology and Experimental Therapeutics, 321(2), 456-463.
  • Lee, J. H., & Park, S. H. (2009). The effects of collagenase on the mechanical properties of collagen-based biomaterials. Biomaterials, 30(10), 1955-1962.
  • Liu, Y., & Zhang, Y. (2011). Collagenase Type IV: A potent enzyme for the treatment of chronic wounds. International Journal of Wound Healing, 3(1), 45-52.
  • Matsumoto, K., & Takahashi, K. (2013). The role of collagenase in the remodeling of extracellular matrix in cancer progression. Cancer Research, 73(12), 3678-3685.
  • Smith, R. A., & Jones, T. (2015). Collagenase from Clostridium histolyticum: A review of its clinical applications in surgery. Surgical Innovation, 22(4), 345-352.
  • Wang, X., & Li, J. (2018). Advances in the use of collagenase in regenerative medicine. Regenerative Medicine, 13(2), 123-130.

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Product Resources:

Manual Manual
Brochure Brochure

Copy of Technical Specifications

FeatureDetails
Viewing Head Siedentopf type trinocular head, inclined at 30°, Interpupillary adjustment 53mm to 75mm, graduated diopter on left eyetube (30mm I.D. eyetubes)
Eyepieces SWH10X Widefield high eyepoint eyepiece, Field No. 22, tube O.D. 30.0 mm
Nosepiece Quintuple
Quintuple LWD Planachromat Phase 10x, 20x
Condenser TC Condenser N.A. 0.30, W.D. 73.0mm
Stage180mm(X) x 245mm(Y) plain stage with replaceable glass insert with 45mm opening, Glass Stage plate insert
IlluminationKoehler without iris, with phase slider, 3W LED
WarrantyLIMITED LIFETIME WARRANTY

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