Collagen Type II from Bovine Nasal – Catalog #B2019206 (10 mg)

High-quality bovine nasal cartilage type II collagen for targeted ECM research and assay development. Collagen Type II from Bovine Nasal Cartilage (Catalog #B2019206, 10 mg) is a biotechnology-grade molecular tool essential for studying cartilage structure, integrity, and turnover across biochemical and immunological workflows. Derived from bovine nasal articular cartilage, this collagen preparation preserves native molecular features—including cross-linking and triple-helical conformation—making it particularly suited for cartilage biology, degradation studies, and extracellular matrix (ECM) modeling.

This product excels in applications ranging from in vitro ECM degradation assays—evaluating proteolytic activity—to cartilage immunolabeling, cell culture matrix integration, and biomechanical testing. Its highly pure, powder format enables precise sample preparation and consistent concentration control. The RT storage simplifies handling across lab settings, while Type I ultrapure water preparation and 0.22 µm filtration ensure batch consistency with reduced biological contaminants.

Cartilage researchers, tissue engineers, and protease assay developers benefit from its use in studying IL-1-induced collagen degradation, cartilage immunogenicity via nasal tolerance models, or tracking ECM remodeling in disease models such as osteoarthritis and autoimmune arthritis. Its authentic origins from bovine nasal cartilage offer a useful proxy for joint cartilage, enabling translational insight in cartilage repair strategies and pathophysiological modeling. For long-term projects or scalable assays, custom orders are available to maintain high-throughput experimental continuity.

Why researchers choose this product:

• Authentic bovine nasal cartilage collagen—preserving relevant ECM structure
• High biotechnology-grade purity ensures low contamination and reliable results
• Powder format with RT storage simplifies assay prep and handling
• Versatile in applications including ECM degradation, cartilage modeling, and immunological assays
• Optimized for studies of cartilage biology, protease activity, and ECM turnover

Indication for Use:
This product is for Research Use Only (RUO). It is not intended for diagnostic, therapeutic, or clinical applications.

References:

• 1: Jansen ID, Hollander AP, Buttle DJ, Everts V. Type II and VI collagen in nasal and articular cartilage and the effect of IL-1alpha on the distribution of these collagens J Mol Histol. 2010 Feb;41(1):9-17.
• 2: Lee-Own V, Anderson JC. Interaction between proteoglycan subunit and type II collagen from bovine nasal cartilage, and the preferential binding of proteoglycan subunit to type I collagen Biochem J. 1976 Feb 1;153(2):259-64.
• 3: Xu C, Oyajobi BO, Frazer A, Kozaci LD, Russell RG, Hollander AP. Effects of growth factors and interleukin-1 alpha on proteoglycan and type II collagen turnover in bovine nasal and articular chondrocyte pellet cultures Endocrinology. 1996 Aug;137(8):3557-65.
• 4: Staines NA, Harper N, Ward FJ. Nasal tolerance to dominant and subdominant epitopes of collagen type II and protection against collagen-induced arthritis Biochem Soc Trans. 1997 May;25(2):661-4.
• 5: Derry CJ, Harper N, Davies DH, Murphy JJ, Staines NA. Importance of dose of type II collagen in suppression of collagen-induced arthritis by nasal tolerance Arthritis Rheum. 2001 Aug;44(8):1917-27.
• 6: Billinghurst RC, Wu W, Ionescu M, Reiner A, Dahlberg L, Chen J, van Wart H, Poole AR. Comparison of the degradation of type II collagen and proteoglycan in nasal and articular cartilages induced by interleukin-1 and the selective inhibition of type II collagen cleavage by collagenase Arthritis Rheum. 2000 Mar;43(3):664-72.
• 7: Adcocks C, Collin P, Buttle DJ. Catechins from green tea (Camellia sinensis) inhibit bovine and human cartilage proteoglycan and type II collagen degradation in vitro J Nutr. 2002 Mar;132(3):341-78.
• 8: Chu CQ, Londei M. Differential activities of immunogenic collagen type II peptides in the induction of nasal tolerance to collagen-induced arthritis J Autoimmun. 1999 Feb;12(1):35-42.
• 9: Ortolani F, Marchini M. Correlation between amino acid composition and ultrastructural features of type I and type II native collagen fibrils Boll Soc Ital Biol Sper. 1993 Feb;69(2):99-106.
• 10: Kozaci LD, Buttle DJ, Hollander AP. Degradation of type II collagen, but not proteoglycan, correlates with matrix metalloproteinase activity in cartilage explant cultures Arthritis Rheum. 1997 Jan;40(1):164-74.