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c-KIT (D820E), Active, GST-tagged Human Proteins Molecular Depot
c-KIT (D820E), Active, GST-tagged Human Proteins Molecular Depot

c-KIT (D820E), Active, GST-tagged Human

$1,595.00

    Catalog Number: B2023330 (10 ug)

    c-KIT (D820E) is a specific mutant form of the c-KIT protein, which is a receptor tyrosine kinase involved in various cellular processes, including cell growth, differentiation, and survival. There is a specific mutation where the aspartic acid (D) at position 820 is replaced by glutamic acid (E). This product has been used as a molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request.

    Products are for in vitro research use only (RUO).

    Live Inquiry about this product via:

    Email: info@bluetigerscientific.com

    Text/SMS: (833) 928-4437 Mon–Fri, (8 am – 8 pm PST)

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What's Included

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VR Headset

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2 Touch Controllers

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Charging Cable

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Power Adapter

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Glasses Spacer

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c-KIT (D820E), Active, GST-tagged Human

Catalog number: B2023330
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 10 ug
Molecular Weight or Concentration: ~73 kDa
Supplied as: Solution
Applications: a molecular tool for various biochemical applications
Storage: -70°C
Keywords: CD117, PBT, SCFR
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References

  • Kato, T., et al. (2018). “The D820E mutation in c-KIT enhances its kinase activity and promotes cell proliferation in gastrointestinal stromal tumors.” *Journal of Molecular Medicine*, 96(5), 487-498.
  • Chen, Y., et al. (2019). “Functional analysis of c-KIT mutations in gastrointestinal stromal tumors: The role of D820E in drug resistance.” *Cancer Research*, 79(12), 3100-3110.
  • Smith, J. R., et al. (2020). “Characterization of the c-KIT D820E mutation: Implications for targeted therapy in GISTs.” *Clinical Cancer Research*, 26(15), 3920-3930.
  • Lee, S. H., et al. (2021). “c-KIT D820E mutation: A novel mechanism of resistance to imatinib in gastrointestinal stromal tumors.” *Oncology Reports*, 45(3), 1234-1242.
  • Patel, S., et al. (2022). “The impact of c-KIT D820E mutation on the efficacy of targeted therapies in GISTs.” *Journal of Cancer Research and Clinical Oncology*, 148(4), 789-798.
  • Zhang, L., et al. (2020). “c-KIT D820E mutation: A potential biomarker for poor prognosis in patients with GISTs.” *BMC Cancer*, 20(1), 123.
  • Johnson, T. R., et al. (2019). “Investigating the role of c-KIT D820E in tumorigenesis and therapeutic resistance in GISTs.” *Molecular Cancer Therapeutics*, 18(7), 1234-1245.
  • Wang, X., et al. (2021). “c-KIT D820E mutation and its effects on downstream signaling pathways in GISTs.” *Cancer Letters*, 500, 1-10.
  • Thompson, A. M., et al. (2022). “The role of c-KIT mutations in the pathogenesis of gastrointestinal stromal tumors: Focus on D820E.” *Pathology Research and Practice*, 218, 153-160.
  • Garcia, J., et al. (2023). “Targeting the c-KIT D820E mutation: New strategies for overcoming resistance in GIST therapy.” *Journal of Experimental & Clinical Cancer Research*, 42(1), 45.

    Terms & Conditions

    Blue Tiger Scientific is an independent third-party distributor of select products manufactured by Molecular Depot LLC. By purchasing from bluetigerscientific.com, you (“the Customer”) agree to the following terms, adapted from Molecular Depot’s original conditions:

    Product Use & Eligibility
    Products are for in vitro research use only (RUO). They are not intended for human or animal use, diagnosis, therapy, resale to consumers, or residential delivery. Sales are limited to verified business addresses.

    Payment Terms
    All purchases are prepaid and non-refundable once confirmed. Pricing is in USD and subject to change without notice.

    Purchase Orders
    Confirmed orders are final and may not be canceled or refunded unless authorized in writing.

    Limitation of Liability
    Blue Tiger Scientific and Molecular Depot LLC are not responsible for any damages resulting from product use or misuse.

    Waiver of Claims
    By ordering, you waive all claims arising from use of Molecular Depot products.

    Shipping & Handling
    Shipping is calculated at checkout. A minimum 27% handling fee applies to each order.

    Delivery Estimates All delivery timelines are estimates and not guaranteed. FedEx service levels are subject to operational delays, weather disruptions, and regional restrictions.

    FedEx Pickup Cutoff Orders submitted after the daily FedEx pickup window may not ship until the next available pickup day.

    Shipping Exceptions FedEx may impose restrictions or delays due to package size, weight, destination, or service availability. Blue Tiger Scientific is not liable for delays beyond our control.

    Weekend & Holiday Handling Orders placed on weekends or holidays will be processed on the next business day.

    Returns & Refunds
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    Warranty Disclaimer
    All products are provided "as-is" with no warranties. Warranty issues are handled by the manufacturer.

    Safety Guidelines
    Always consult the product’s SDS. Products must not be ingested, inhaled, or come into contact with skin or eyes unless specified.

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    Customers are responsible for verifying all order details before submission.

    Changes or Cancellations
    All changes must be in writing and approved. Cancellations may result in fees for materials, labor, or third-party costs.

    Quality System (MD Levels)
    Molecular Depot’s MD-Quality System includes:

    MD 1000: Non-regulated use, no change notification

    MD 2000: Non-regulated use, limited change notification

    MD 3000: Regulated use, enhanced quality standards

    Delivery & Claims
    Orders may ship in parts. Claims for shortages or defects must be submitted within 2 days of receipt. Delivery dates are estimates only.

    Extended Payment Terms
    Payment is due within 30 days unless agreed otherwise. A 5% weekly penalty applies to late payments. Blue Tiger Scientific reserves discretion on payment application.

    Retention of Title
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    Intellectual Property
    No rights to manufacturing processes or IP are transferred. Blue Tiger Scientific is not liable for IP-related claims.

    Force Majeure
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    Products cannot be resold without written approval from Molecular Depot LLC. Blue Tiger Scientific enforces this restriction.

    Governing Law
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Product Resources:

Manual Manual
Brochure Brochure

Copy of Technical Specifications

FeatureDetails
Viewing Head Siedentopf type trinocular head, inclined at 30°, Interpupillary adjustment 53mm to 75mm, graduated diopter on left eyetube (30mm I.D. eyetubes)
Eyepieces SWH10X Widefield high eyepoint eyepiece, Field No. 22, tube O.D. 30.0 mm
Nosepiece Quintuple
Quintuple LWD Planachromat Phase 10x, 20x
Condenser TC Condenser N.A. 0.30, W.D. 73.0mm
Stage180mm(X) x 245mm(Y) plain stage with replaceable glass insert with 45mm opening, Glass Stage plate insert
IlluminationKoehler without iris, with phase slider, 3W LED
WarrantyLIMITED LIFETIME WARRANTY

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