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ANP (Human, 1-28) Chemicals Molecular Depot
ANP (Human, 1-28) Chemicals Molecular Depot

ANP (Human, 1-28)

$795.00

    Catalog Number: MDP0506 (500 ug)

    ANP (Human, 1-28) is a synthetic peptide consisting of the sequence: Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Met-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr (Disulfide bond between Cys7-Cys23). The molecular weight of this peptide is 3080.4 g/mol and the CAS number is 133605-57-9. This product is for in vitro research use only. This product is not for human or animal use. Custom bulk amounts of this product are available upon request.

    Products are for in vitro research use only (RUO).

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ANP (Human, 1–28)

Catalog # MDP0506
CAS # 133605-57-9
Amount 500 μg
Molecular Weight 3080.4 g/mol
Sequence Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Met-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr
Disulfide bond: Cys7–Cys23
Supplied as Powder
Storage -20°C
Applications Molecular tool for biochemical research
Grade Biotechnology grade

ANP (Human, 1–28) is a biotechnology-grade peptide corresponding to the full-length active form of atrial natriuretic peptide. With a molecular weight of 3080.4 g/mol, this 28-residue hormone plays a pivotal role in cardiovascular homeostasis by promoting natriuresis, vasodilation, and inhibition of the renin-angiotensin-aldosterone system. The peptide contains a conserved disulfide bond between Cys7 and Cys23, essential for its biological activity and receptor binding affinity.

Supplied as a 500 μg powder aliquot, ANP (1–28) is widely used in studies of blood pressure regulation, endothelial function, and renal physiology. It has demonstrated antiproliferative effects on airway smooth muscle cells and modulates endothelin-1 secretion in endothelial cultures. Researchers also employ this peptide in pharmacological assays, receptor binding studies, and investigations into peptide metabolism and clearance. ANP (1–28) is stable at -20°C and should be reconstituted in sterile buffer prior to use. All components are highly pure and RUO-compliant—this product is not intended for human or animal use.

Key benefits:

  • Full-length active form of human atrial natriuretic peptide
  • Validated in cardiovascular, renal, and endothelial research
  • Conserved disulfide bond for structural and functional integrity
  • Stable at -20°C; powder format for flexible reconstitution
  • RUO-compliant: not for clinical or veterinary use

Indication for Use:
This product is for Research Use Only (RUO). It is not intended for human or animal use, diagnostic procedures, or therapeutic applications.

References:

  • Gunnarsson U. Intracerebroventricular ANP(1–28) has no obvious effects on renal blood flow and function in conscious sheep. Clin Exp Pharmacol Physiol. 1994 Mar;21(3):189–94.
  • Gianello P et al. Effect of 1–28 alpha-h atrial natriuretic peptide on acute renal failure in cadaveric renal transplantation. Clin Transplant. 1995 Dec;9(6):481–9.
  • Ronit A et al. Plasma Albumin and Incident Cardiovascular Disease: Results From the CGPS and an Updated Meta-Analysis. Arterioscler Thromb Vasc Biol. 2020 Feb;40(2):473–482.
  • Macheret F et al. Human hypertension is characterized by a lack of activation of the antihypertensive cardiac hormones ANP and BNP. J Am Coll Cardiol. 2012 Oct 16;60(16):1558–65.
  • Hamad AM et al. Antiproliferative effects of NO and ANP in cultured human airway smooth muscle. Am J Physiol. 1999 Nov;277(5):L910–8.
  • Kohno M et al. Inhibition by atrial and brain natriuretic peptides of endothelin-1 secretion after stimulation with angiotensin II and thrombin of cultured human endothelial cells. J Clin Invest. 1991 Jun;87(6):1999–2004.
  • Brandt I et al. Dipeptidyl-peptidase IV converts intact B-type natriuretic peptide into its des-SerPro form. Clin Chem. 2006 Jan;52(1):82–7.
  • Wambach G et al. [Atrial natriuretic peptide and its significance for arterial hypertension]. Klin Wochenschr. 1989 Nov 3;67(21):1069–76.
  • Hughes A et al. Direct effect of alpha-human atrial natriuretic peptide on human vasculature in vivo and in vitro. Clin Sci (Lond). 1988 Feb;74(2):207–11.
  • Delporte C et al. Discovery of a potent atrial natriuretic peptide antagonist for ANPA receptors in the human neuroblastoma NB-OK-1 cell line. Eur J Pharmacol. 1992 Dec 2;224(2–3):183–8.

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Copy of Technical Specifications

FeatureDetails
Viewing Head Siedentopf type trinocular head, inclined at 30°, Interpupillary adjustment 53mm to 75mm, graduated diopter on left eyetube (30mm I.D. eyetubes)
Eyepieces SWH10X Widefield high eyepoint eyepiece, Field No. 22, tube O.D. 30.0 mm
Nosepiece Quintuple
Quintuple LWD Planachromat Phase 10x, 20x
Condenser TC Condenser N.A. 0.30, W.D. 73.0mm
Stage180mm(X) x 245mm(Y) plain stage with replaceable glass insert with 45mm opening, Glass Stage plate insert
IlluminationKoehler without iris, with phase slider, 3W LED
WarrantyLIMITED LIFETIME WARRANTY

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