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Neuromedin U (Mouse) Chemicals Molecular Depot
Neuromedin U (Mouse) Chemicals Molecular Depot
Neuromedin U (Mouse) Chemicals Molecular Depot
Neuromedin U (Mouse) Chemicals Molecular Depot

Neuromedin U (Mouse)

$907.00

    Catalog Number: MDP0842 (500 ug)

    Neuromedin U (Mouse) is a synthetic peptide consisting of the sequence: Phe-Lys-Ala-Glu-Tyr-Gln-Ser-Pro-Ser-Val-Gly-Gln-Ser-Lys-Gly-Tyr-Phe-Leu-Phe-Arg-Pro-Arg-Asn-NH2. The molecular weight of this peptide is 2706 g/mol and the CAS number is 935658-91-6. This product is for in vitro research use only. This product is not for human or animal use. Custom bulk amounts of this product are available upon request.

    Products are for in vitro research use only (RUO).

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Neuromedin U (Mouse)

Catalog # MDP0842
CAS # 935658-91-6
Amount 500 μg
Molecular Weight 2706 g/mol
Sequence Phe-Lys-Ala-Glu-Tyr-Gln-Ser-Pro-Ser-Val-Gly-Gln-Ser-Lys-Gly-Tyr-Phe-Leu-Phe-Arg-Pro-Arg-Asn-NH₂
Supplied as Powder
Storage -20°C
Applications Molecular tool for biochemical research
Grade Biotechnology grade

Neuromedin U (Mouse) is a biotechnology-grade neuropeptide supplied as a highly pure powder for in vitro research use. With a molecular weight of 2706 g/mol, this 23-residue peptide plays a critical role in modulating immune responses, energy homeostasis, and neuroendocrine signaling. Its sequence terminates in an amidated Asn residue, a structural feature essential for receptor binding and biological activity.

This reagent is widely used in studies of type 2 innate lymphoid cells (ILC2), allergic inflammation, and hypothalamic signaling. It is supplied in 500 μg aliquots and should be stored at -20°C. All applications must comply with RUO guidelines—this product is not intended for use in humans or animals.

Key benefits:

  • Biotechnology-grade purity for reproducible in vitro assays
  • Amidated C-terminus for enhanced receptor binding
  • Validated in ILC2, neuroendocrine, and inflammation studies
  • Stable at -20°C; powder format for flexible reconstitution
  • RUO-compliant: not for clinical or veterinary use

Indication for Use:
This product is for Research Use Only (RUO). It is not intended for human or animal use, diagnostic procedures, or therapeutic applications.

References:

  • Cardoso V, Chesné J, Ribeiro H, García-Cassani B, Carvalho T, Bouchery T, Shah K, Barbosa-Morais NL, Harris N, Veiga-Fernandes H. Neuronal regulation of type 2 innate lymphoid cells via neuromedin U. Nature. 2017 Sep 14;549(7671):277-281.
  • Klose CSN, Mahlakõiv T, Moeller JB, Rankin LC, Flamar AL, Kabata H, Monticelli LA, Moriyama S, Putzel GG, Rakhilin N, Shen X, Kostenis E, König GM, Senda T, Carpenter D, Farber DL, Artis D. The neuropeptide neuromedin U stimulates innate lymphoid cells and type 2 inflammation. Nature. 2017 Sep 14;549(7671):282-286.
  • Jarick KJ, Topczewska PM, Jakob MO, Yano H, Arifuzzaman M, Gao X, Boulekou S, Stokic-Trtica V, Leclère PS, Preußer A, Rompe ZA, Stamm A, Tsou AM, Chu C, Heinrich FR, Guerra GM, Durek P, Ivanov A, Beule D, Helfrich S, Duerr CU, Kühl AA, Stehle C, Romagnani C, Mashreghi MF, Diefenbach A, Artis D, Klose CSN. Non-redundant functions of group 2 innate lymphoid cells. Nature. 2022 Nov;611(7937):794-800.
  • Wallrapp A, Riesenfeld SJ, Burkett PR, Abdulnour RE, Nyman J, Dionne D, Hofree M, Cuoco MS, Rodman C, Farouq D, Haas BJ, Tickle TL, Trombetta JJ, Baral P, Klose CSN, Mahlakõiv T, Artis D, Rozenblatt-Rosen O, Chiu IM, Levy BD, Kowalczyk MS, Regev A, Kuchroo VK. The neuropeptide NMU amplifies ILC2-driven allergic lung inflammation. Nature. 2017 Sep 21;549(7672):351-356.
  • Tsou AM, Yano H, Parkhurst CN, Mahlakõiv T, Chu C, Zhang W, He Z, Jarick KJ, Zhong C, Putzel GG, Hatazaki M; JRI IBD Live Cell Bank Consortium; Lorenz IC, Andrew D, Balderes P, Klose CSN, Lira SA, Artis D. Neuropeptide regulation of non-redundant ILC2 responses at barrier surfaces. Nature. 2022 Nov;611(7937):787-793.
  • Nagashima H, Mahlakõiv T, Shih HY, Davis FP, Meylan F, Huang Y, Harrison OJ, Yao C, Mikami Y, Urban JF Jr, Caron KM, Belkaid Y, Kanno Y, Artis D, O’Shea JJ. Neuropeptide CGRP Limits Group 2 Innate Lymphoid Cell Responses and Constrains Type 2 Inflammation. Immunity. 2019 Oct 15;51(4):682-695.e6.
  • Graham ES, Turnbull Y, Fotheringham P, Nilaweera K, Mercer JG, Morgan PJ, Barrett P. Neuromedin U and Neuromedin U receptor-2 expression in the mouse and rat hypothalamus: effects of nutritional status. J Neurochem. 2003 Dec;87(5):1165-73.
  • Steel JH, Van Noorden S, Ballesta J, Gibson SJ, Ghatei MA, Burrin J, Leonhardt U, Domin J, Bloom SR, Polak JM. Localization of 7B2, neuromedin B, and neuromedin U in specific cell types of rat, mouse, and human pituitary, in rat hypothalamus, and in 30 human pituitary and extrapituitary tumors. Endocrinology. 1988 Jan;122(1):270-82.
  • Teranishi H, Hayashi M, Higa R, Mori K, Miyazawa T, Hino J, Amano Y, Tozawa R, Ida T, Hanada T, Miyazato M, Hanada R, Kangawa K, Nakao K. Role of neuromedin U in accelerating of non-alcoholic steatohepatitis in mice. Peptides. 2018 Jan;99:134-141.
  • Vestlund J, Kalafateli AL, Studer E, Westberg L, Jerlhag E. Neuromedin U induces self-grooming in socially-stimulated mice. Neuropharmacology. 2020 Jan 1;162:107818.

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Product Resources:

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Copy of Technical Specifications

FeatureDetails
Viewing Head Siedentopf type trinocular head, inclined at 30°, Interpupillary adjustment 53mm to 75mm, graduated diopter on left eyetube (30mm I.D. eyetubes)
Eyepieces SWH10X Widefield high eyepoint eyepiece, Field No. 22, tube O.D. 30.0 mm
Nosepiece Quintuple
Quintuple LWD Planachromat Phase 10x, 20x
Condenser TC Condenser N.A. 0.30, W.D. 73.0mm
Stage180mm(X) x 245mm(Y) plain stage with replaceable glass insert with 45mm opening, Glass Stage plate insert
IlluminationKoehler without iris, with phase slider, 3W LED
WarrantyLIMITED LIFETIME WARRANTY

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