Malonyl Coenzyme A – Catalog Number: B2012921 (1 mg)

Malonyl Coenzyme A (Malonyl-CoA) is supplied as a lyophilized powder in a defined 1 mg amount (Catalog B2012921) with a listed molecular weight of 860.5 g/mol. As described by the supplier, it is a coenzyme A derivative used in fatty acid and polyketide synthesis and is positioned for use as a molecular tool for various biochemical applications. Storage is specified at −20 °C. The clear specification set—amount, supplied-as, molecular weight, storage, and keyword identity—supports straightforward documentation and SOP integration for teams standardizing workflows that involve acyl-carrier chemistry or model pathway studies.

Within research method development, a well-characterized Malonyl-CoA standard is useful when establishing handling and recovery steps, tuning qualitative readouts that depend on CoA thioesters, or benchmarking assay components under controlled conditions. The lyophilized format offers flexibility in buffer choice for reconstitution and facilitates aliquoting to minimize freeze–thaw cycles once stocks are prepared. Because this product is provided as a research reagent rather than a prequalified assay component, good practice is to determine working concentrations empirically in small-scale pilots, recording buffer composition, pH, and time-at-temperature to ensure reproducibility across instruments and operators.

Typical use scenarios include assembling proof-of-concept reactions that reference fatty-acid or polyketide modules, setting up stability or adsorption checks for CoA thioesters, or constructing internal references for comparative runs. The biotechnology-grade note—solutions prepared with Type I ultrapure water and 0.22 µm filtration—aligns with expectations for low background and consistent behavior in bench-scale biochemical applications. Together, the concise specifications and user-controlled reconstitution make this Malonyl-CoA a practical choice for laboratories building or validating methods that interface with acyl-transfer chemistry in research contexts.

Why researchers choose this product:

• Defined 1 mg amount with listed 860.5 g/mol molecular weight for precise documentation
• Convenient lyophilized powder format for flexible reconstitution and aliquoting
• Specified storage at −20 °C supports stability planning
• Described use in fatty acid and polyketide synthesis contexts (supplier statement)
• Biotechnology-grade preparation (Type I water; 0.22 µm filtration for solutions)

This product is for Research Use Only (RUO). It is not intended for diagnostic or therapeutic use.

References

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• 2: Qiu C, Huang M, Hou Y, Tao H, Zhao J, Shen Y, Bao X, Qi Q, Hou J. Biosensor-Coupled In Vivo Mutagenesis and Omics Analysis Reveals Reduced Lysine and Arginine Synthesis To Improve Malonyl_Coenzyme A Flux in Saccharomyces cerevisiae mSystems. 2022 Apr 26;7(2):e0136621.
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• 7: Patil PB, Minteer SD, Mielke AA, Lewis LR, Casmaer CA, Barrientos EJ, Ju JS, Smith JL, Fisher JS. Malonyl_coenzyme_A affects insulin-stimulated glucose transport in myotubes Arch Physiol Biochem. 2007 Feb;113(1):13-24.
• 8: Tosin M, Spiteller D, Spencer JB. Malonyl carba(dethia)- and malonyl oxa(dethia)-coenzyme A as tools for trapping polyketide intermediates Chembiochem. 2009 Jul 6;10(10):1714-23.
• 9: Mitzen EJ, Koeppen AH. Malonate, malonyl-coenzyme A, and acetyl-coenzyme A in developing rat brain J Neurochem. 1984 Aug;43(2):499-506.
• 10: HUELSMANN WC. SYNTHESIS OF MALONYL-COENZYME A FROM ACETYL-COENZYME A AND OXALOSUCCINATE IN MITOCHONDRIA Biochim Biophys Acta. 1963 Nov 8;77:502-3.