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Laminin Pentapeptide YIGSR-NH2 Peptides Molecular Depot
Laminin Pentapeptide YIGSR-NH2 Peptides Molecular Depot
Laminin Pentapeptide YIGSR-NH2 Peptides Molecular Depot
Laminin Pentapeptide YIGSR-NH2 Peptides Molecular Depot
Laminin Pentapeptide YIGSR-NH2 Peptides Molecular Depot
Laminin Pentapeptide YIGSR-NH2 Peptides Molecular Depot

Laminin Pentapeptide YIGSR-NH2

$647.00

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Laminin Pentapeptide YIGSR-NH₂ (Highly Pure)

Catalog # MDP0579
Price per 5 mg $299
Name Tyr-Ile-Gly-Ser-Arg-NH₂ · 2AcOH · 2H₂O
Synonyms Laminin Pentapeptide YIGSR-NH₂
Molecular Formula C₂₆H₄₃N₉O₇
Molecular Mass 593.68 g/mol
CAS # 110590-65-3
Storage −20°C

Laminin Pentapeptide YIGSR-NH₂ is a synthetic peptide derived from the B1 chain of laminin, a key component of the extracellular matrix. This five-residue sequence (Tyr-Ile-Gly-Ser-Arg) is known for its ability to mediate cell adhesion, promote tissue organization, and interact with the 67 kDa laminin receptor. It is widely used in cell culture, tissue engineering, and metastasis inhibition studies.

Researchers leverage YIGSR-NH₂ to enhance cellular attachment, guide neural stem cell behavior, and study integrin-mediated signaling. Its role in modulating epidermal development, platelet aggregation, and tumor cell dissemination makes it a versatile tool across oncology, regenerative medicine, and biomaterials science. The peptide is supplied as a diacetate dihydrate salt for improved solubility and stability in aqueous systems.

Each batch is rigorously purified and validated for reproducibility in in vitro assays. Laminin Pentapeptide YIGSR-NH₂ is Research Use Only (RUO) and not intended for diagnostic or therapeutic applications. For safety and handling, refer to the product’s MSDS.

Key Features:

  • Five-residue laminin-derived peptide with terminal amide modification
  • Promotes cell adhesion and receptor binding in vitro
  • Validated in neural, epidermal, and metastatic models
  • CAS #: 110590-65-3; Molecular Mass: 593.68 g/mol
  • RUO designation: not for clinical or therapeutic applications

Indication for Use:
This product is for Research Use Only (RUO). It is not intended for human or animal use, diagnostic procedures, or therapeutic applications.

Safety:
Users must review the Material Safety Data Sheet (MSDS) prior to handling. Avoid ingestion, inhalation, or contact with eyes, skin, or clothing.

References
1: Yin Y, Wang W, Shao Q, Li B, Yu D, Zhou X, Parajuli J, Xu H, Qiu T, Yetisen AK, Jiang N. Pentapeptide IKVAV-engineered hydrogels for neural stem cell attachment Biomater Sci. 2021 Apr 21;9(8):2887-2892.
2: Kim YY, Li H, Song YS, Jeong HS, Yun HY, Baek KJ, Kwon NS, Shin YK, Park KC, Kim DS. Laminin peptide YIGSR enhances epidermal development of skin equivalents Am J Hosp Pharm. 1991 Mar;48(3):501-6.
3: Graf J, Ogle RC, Robey FA, Sasaki M, Martin GR, Yamada Y, Kleinman HK. A pentapeptide from the laminin B1 chain mediates cell adhesion and binds the 67,000 laminin receptor Biochemistry. 1987 Nov 3;26(22):6896-900.
4: Jain R, Roy S. Tuning the gelation behavior of short laminin derived peptides via solvent mediated self-assembly Mater Sci Eng C Mater Biol Appl. 2020 Mar;108:110483.
5: Iwamoto Y, Robey FA, Graf J, Sasaki M, Kleinman HK, Yamada Y, Martin GR. YIGSR, a synthetic laminin pentapeptide, inhibits experimental metastasis formation Science. 1987 Nov 20;238(4830):1132-4.
6: McMahon JP, Wheat J, Sobel ME, Pasula R, Downing JF, Martin WJ 2nd. Murine laminin binds to Histoplasma capsulatum. A possible mechanism of dissemination J Cosmet Sci. 2003 Nov-Dec;54(6):537-50.
7: Hadley MA, Weeks BS, Kleinman HK, Dym M. Laminin promotes formation of cord-like structures by Sertoli cells in vitro Dev Biol. 1990 Aug;140(2):318-27.
8: Dalet-Fumeron V, Boudjennah L, Pagano M. Binding of the cysteine proteinases papain and cathepsin B-like to coated laminin: use of synthetic peptides from laminin and from the laminin binding region of the beta 1 integrin subunit to characterize the binding site Arch Biochem Biophys. 1998 Oct 15;358(2):283-90.
9: Tung PS, Fritz IB. Interactions of Sertoli cells with laminin are essential to maintain integrity of the cytoskeleton and barrier functions of cells in culture in the two-chambered assembly J Cell Physiol. 1993 Jul;156(1):1-11.
10: Willette RN, Storer BL, Clark RK, Ohlstein EH. Human laminin produces human platelet aggregation in vitro Life Sci. 1994;55(5):379-88.

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Product Resources:

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Copy of Technical Specifications

FeatureDetails
Viewing Head Siedentopf type trinocular head, inclined at 30°, Interpupillary adjustment 53mm to 75mm, graduated diopter on left eyetube (30mm I.D. eyetubes)
Eyepieces SWH10X Widefield high eyepoint eyepiece, Field No. 22, tube O.D. 30.0 mm
Nosepiece Quintuple
Quintuple LWD Planachromat Phase 10x, 20x
Condenser TC Condenser N.A. 0.30, W.D. 73.0mm
Stage180mm(X) x 245mm(Y) plain stage with replaceable glass insert with 45mm opening, Glass Stage plate insert
IlluminationKoehler without iris, with phase slider, 3W LED
WarrantyLIMITED LIFETIME WARRANTY

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