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Histamine N-Methyl Transferase (HNMT) Proteins Molecular Depot
Histamine N-Methyl Transferase (HNMT) Proteins Molecular Depot
Histamine N-Methyl Transferase (HNMT) Proteins Molecular Depot
Histamine N-Methyl Transferase (HNMT) Proteins Molecular Depot

Histamine N-Methyl Transferase (HNMT)

$595.00

    Catalog Number: B2013479 (1 mg)

    Histamine N-Methyl Transferase (HNMT) is native, highly purified, Histamine N-Methyl Transferase (HNMT). This product has been used as molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. For in vitro research use only. Custom bulk amounts of this product are available upon request.

    Products are for in vitro research use only (RUO).

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Histamine N-Methyl Transferase (HNMT)

Catalog # B2013479
Lot # Batch dependent
Expiration Batch dependent
Amount 1 mg
Activity 50–100 U/mg
Supplied as Lyophilized powder
Storage –20°C
Keywords Histamine N-Methyl Transferase
Grade Biotechnology grade; ultrapure water (>18 MΩ·cm); filtered through 0.22 µm

Histamine N-Methyl Transferase (HNMT) is a cytosolic enzyme responsible for the methylation of histamine, converting it into N-methylhistamine. This reaction plays a critical role in histamine metabolism, particularly in tissues where diamine oxidase is absent. Supplied as a lyophilized powder, this highly purified preparation offers an activity range of 50–100 U/mg and is ideal for use in pharmacological, neurological, and immunological research.

HNMT is a key target in studies of histamine-related disorders, including migraines, multiple sclerosis, and allergic responses. It is also relevant in drug metabolism and adverse reaction profiling, especially in the context of H2-antihistamines and neuromodulators. This product is stable at –20°C and should be reconstituted in sterile buffer for optimal performance. All solutions are prepared using Type I ultrapure water and filtered through 0.22 µm membranes to ensure consistency and reproducibility across batches.

Key benefits:

  • High-purity HNMT enzyme for histamine metabolism studies
  • Validated activity range (50–100 U/mg)
  • Lyophilized format for long-term stability
  • Supports research in neurology, immunology, and pharmacogenetics
  • Ideal for inhibitor screening and polymorphism analysis

Indication for Use:
This product is for Research Use Only (RUO). It is not intended for human or animal use, diagnostic procedures, or therapeutic applications.

References:

  • Jiménez EM, Żołek T, Hernández Perez PG, Miranda Ruvalcaba R, Nicolás-Vázquez MI, Hernández-Rodríguez M. Drug Repurposing to Inhibit Histamine N-Methyl Transferase Molecules. 2023 Jan 6;28(2):576.
  • García-Martín E, Martínez C, Benito-León J, Calleja P, Díaz-Sánchez M, Pisa D, Alonso-Navarro H, Ayuso-Peralta L, Torrecilla D, Agúndez JA, Jiménez-Jiménez FJ. Histamine-N-methyl transferase polymorphism and risk for multiple sclerosis Eur J Neurol. 2010 Feb;17(2):335-8.
  • García-Martín E, Martínez C, Serrador M, Alonso-Navarro H, Navacerrada F, Agúndez JA, Jiménez-Jiménez FJ. Histamine-N-methyl transferase polymorphism and risk for migraine Headache. 2008 Oct;48(9):1343-8.
  • Ichinose W, Sawato T, Kitano H, Shinozaki Y, Arisawa M, Saito N, Yoshikawa T, Yamaguchi M. Optically active iodohelicene derivatives exhibit histamine N-methyl transferase inhibitory activity J Antibiot (Tokyo). 2019 Jun;72(6):476-481.
  • Futo J, Kupferberg JP, Moss J. Inhibition of histamine N-methyltransferase (HNMT) in vitro by neuromuscular relaxants Biochem Pharmacol. 1990 Feb 1;39(3):415-20.
  • Jiménez-Jiménez FJ, García-Martín E, Alonso-Navarro H, Martínez C, Zurdo M, Turpín-Fenoll L, Millán-Pascual J, Adeva-Bartolomé T, Cubo E, Navacerrada F, Rojo-Sebastián A, Rubio L, Ortega-Cubero S, Pastor P, Calleja M, Plaza-Nieto JF, Pilo-de-la-Fuente B, Arroyo-Solera M, García-Albea E, Agúndez JA. Thr105Ile (rs11558538) polymorphism in the histamine-1-methyl-transferase (HNMT) gene and risk for restless legs syndrome J Neural Transm (Vienna). 2017 Mar;124(3):285-291.
  • Vinod PK, Konkimalla B, Chandra N. In-silico pharmacodynamics: correlation of adverse effects of H2-antihistamines with histamine N-methyl transferase binding potential Appl Bioinformatics. 2006;5(3):141-50.
  • Sachidanandam K, Gayle AA, Robins HI, Kolesar JM. Unexpected doxorubicin-mediated cardiotoxicity in sisters: possible role of polymorphisms in histamine n-methyl transferase J Oncol Pharm Pract. 2013 Sep;19(3):269-72.
  • Crooks PA, Hassan SF, Benghiat E, Hemrick-Luecke SK, Fuller RW. 5′-thioadenosine derivatives as potent and selective inhibitors of histamine N-methyltransferase Drug Metabol Drug Interact. 1989;7(2-3):111-41.
  • Valen G, Kaszaki J, Szabo I, Nagy S, Vaage J. Activity of histamine metabolizing and catabolizing enzymes during reperfusion of isolated, globally ischemic rat hearts Inflamm Res. 1996 Mar;45(3):145-9.

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Product Resources:

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Copy of Technical Specifications

FeatureDetails
Viewing Head Siedentopf type trinocular head, inclined at 30°, Interpupillary adjustment 53mm to 75mm, graduated diopter on left eyetube (30mm I.D. eyetubes)
Eyepieces SWH10X Widefield high eyepoint eyepiece, Field No. 22, tube O.D. 30.0 mm
Nosepiece Quintuple
Quintuple LWD Planachromat Phase 10x, 20x
Condenser TC Condenser N.A. 0.30, W.D. 73.0mm
Stage180mm(X) x 245mm(Y) plain stage with replaceable glass insert with 45mm opening, Glass Stage plate insert
IlluminationKoehler without iris, with phase slider, 3W LED
WarrantyLIMITED LIFETIME WARRANTY

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