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Fluorogenic Furin Substrate Chemicals Molecular Depot
Fluorogenic Furin Substrate Chemicals Molecular Depot
Fluorogenic Furin Substrate Chemicals Molecular Depot
Fluorogenic Furin Substrate Chemicals Molecular Depot

Fluorogenic Furin Substrate

$595.00

    Catalog Number: B2012668 (5 mg)

    Fluorogenic Furin Substrate is a high quality fluorogenic substrate for furin, a mammalian homolog of the yeast Kex2 endoprotease. This product has been used as molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request.

    Products are for in vitro research use only (RUO).

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What's Included

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VR Headset

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2 Touch Controllers

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Charging Cable

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Power Adapter

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Fluorogenic Furin Substrate

Catalog number: B2012668
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 5 mg
Molecular Weight or Concentration: 827.9 g/mol
Supplied as: Lyophilized Powder
Applications: molecular tool for various biochemical applications
Storage: -20°C
Keywords: Furin Substrate, Fluorogenic
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References

  • Zhu J, Declercq J, Creemers JW, Chen C, Cui Y, Van de Ven WJ, Vermorken AJ. Limitations of inhibitory activities of polyphenols on furin-mediated substrate processing Curr Med Chem. 2012;19(21):3641-50.
  • Angliker H, Neumann U, Molloy SS, Thomas G. Internally quenched fluorogenic substrate for furin Anal Biochem. 1995 Jan 1;224(1):409-12.
  • Jean F, Basak A, DiMaio J, Seidah NG, Lazure C. An internally quenched fluorogenic substrate of prohormone convertase 1 and furin leads to a potent prohormone convertase inhibitor Biochem J. 1995 May 1;307 ( Pt 3)(Pt 3):689-95.
  • Lam van TV, Ivanova T, Lindberg I, Böttcher-Friebertshäuser E, Steinmetzer T, Hardes K. Design, synthesis, and characterization of novel fluorogenic substrates of the proprotein convertases furin, PC1/3, PC2, PC5/6, and PC7 Anal Biochem. 2022 Oct 15;655:114836.
  • Zaragoza-Huesca D, Martínez-Cortés C, Banegas-Luna AJ, Pérez-Garrido A, Vegara-Meseguer JM, Peñas-Martínez J, Rodenas MC, Espín S, Pérez-Sánchez H, Martínez-Martínez I. Identification of Kukoamine A, Zeaxanthin, and Clexane as New Furin Inhibitors Int J Mol Sci. 2022 Mar 3;23(5):2796.
  • Tanikawa T, Hayashi T, Suzuki R, Kitamura M, Inoue Y. Inhibitory effect of honokiol on furin-like activity and SARS-CoV-2 infection J Tradit Complement Med. 2022 Jan;12(1):69-72.
  • Fei H, Li Y, Wang LX, Luo MJ, Ling MH, Chi CW. Nonhistone protein purified from porcine kidney acts as a suicide substrate inhibitor on furin-like enzyme Acta Pharmacol Sin. 2000 Mar;21(3):265-70.
  • Lazure C, Gauthier D, Jean F, Boudreault A, Seidah NG, Bennett HP, Hendy GN. In vitro cleavage of internally quenched fluorogenic human proparathyroid hormone and proparathyroid-related peptide substrates by furin. Generation of a potent inhibitor J Biol Chem. 1998 Apr 10;273(15):8572-80.
  • Rozan L, Krysan DJ, Rockwell NC, Fuller RS. Plasticity of extended subsites facilitates divergent substrate recognition by Kex2 and furin J Biol Chem. 2004 Aug 20;279(34):35656-63.

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Product Resources:

Manual Manual
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Copy of Technical Specifications

FeatureDetails
Viewing Head Siedentopf type trinocular head, inclined at 30°, Interpupillary adjustment 53mm to 75mm, graduated diopter on left eyetube (30mm I.D. eyetubes)
Eyepieces SWH10X Widefield high eyepoint eyepiece, Field No. 22, tube O.D. 30.0 mm
Nosepiece Quintuple
Quintuple LWD Planachromat Phase 10x, 20x
Condenser TC Condenser N.A. 0.30, W.D. 73.0mm
Stage180mm(X) x 245mm(Y) plain stage with replaceable glass insert with 45mm opening, Glass Stage plate insert
IlluminationKoehler without iris, with phase slider, 3W LED
WarrantyLIMITED LIFETIME WARRANTY

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