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Collagenase from Clostridium Histolyticum Proteins Molecular Depot
Collagenase from Clostridium Histolyticum Proteins Molecular Depot
Collagenase from Clostridium Histolyticum Proteins Molecular Depot
Collagenase from Clostridium Histolyticum Proteins Molecular Depot

Collagenase from Clostridium Histolyticum

$387.00

    Catalog Number: B2010529 (100 mg)

    Collagenase from Clostridium histolyticum is a highly pure protease that cleaves the triple-helical structure of collagen. This product has been used as molecular tool in various cellular biology applications. It has also been used in a wide array of other biochemical and immunological applications. Custom bulk amounts of this product are available upon request.

    Products are for in vitro research use only (RUO).

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Collagenase from Clostridium histolyticum – Catalog #B2010529 (100 mg)

Catalog # B2010529
Lot # Batch dependent
Expiration Batch dependent
Amount 100 mg
Molecular Weight 68–125 kDa
Supplied As Powder
Applications Versatile protease tool for molecular, biochemical, and immunological workflows
Storage –20 °C
Grade Biotechnology grade; high purity; prepared with Type I ultrapure water (>18 MΩ·cm) and filtered through 0.22 µm
Keywords Clostridiopeptidase A, Collagenase from Clostridium histolyticum

High-purity bacterial collagenase engineered for dependable and efficient collagen degradation across diverse RUO applications. Collagenase from Clostridium histolyticum (Catalog #B2010529, 100 mg) is a biotechnology-grade, lyophilized enzyme preparation specifically designed to cleave the triple-helical structure of collagen with high precision. Originating from the potent proteolytic activity of C. histolyticum, this collagenase is optimized for reproducible performance in molecular biology, tissue dissociation, proteomic workflows, and immunological assays, especially where accurate, lot-consistent enzyme activity is critical.

This enzyme provides robust and reliable collagen breakdown, enabling effective tissue dissociation to liberate primary cells while preserving cellular integrity. It is similarly valued for extracellular matrix (ECM) preparation, degradation profiling, and protein isolation applications in complex biological samples. Manufactured under rigorous biotech-grade conditions with ultrapure water and microfiltration, this collagenase delivers a low-impurity profile and consistent activity that enhance the fidelity of sensitive downstream assays.

Whether utilized for organoid culture setup, histological ECM clearance, or standardization of enzyme activity assays, this reagent supports scalability and adaptability. The generous 100 mg supply and customizable bulk quantities ensure long-term experimental access and seamless integration into high-throughput pipelines. Researchers in fields such as structural biology, regenerative medicine, and assay development consistently trust this collagenase for its potency, purity, and compatibility with RUO research protocols.

Why researchers choose this product:

  • Ultra-pure collagenase for precise and consistent collagen digestion
  • Powder format ensures long-term stability and flexible dosing
  • Biotech-grade manufacturing supports reproducibility across experiments
  • High yield (100 mg) and bulk availability optimize workflow continuity
  • Versatile in applications from tissue dissociation to proteomic prep

Indication for Use:
This product is for Research Use Only (RUO). It is not intended for clinical, diagnostic, or therapeutic applications.

References:

  • 1: Amighi A, Eleswarapu SV, Mendhiratta N, Nork JJ, Mills JN. Discontinuation from Collagenase Clostridium histolyticum Therapy for Peyronie’s Disease: Review and Single-Center Cohort Analysis. Sex Med Rev. 2019 Oct;7(4):690-698.
  • 2: Mills SA, Gelbard MK. Sixty years in the making: collagenase Clostridium histolyticum, from benchtop to FDA approval and beyond. World J Urol. 2020 Feb;38(2):269-277.
  • 3: Sadick NS, Goldman MP, Liu G, Shusterman NH, McLane MP, Hurley D, Young VL. Collagenase Clostridium histolyticum for the Treatment of Edematous Fibrosclerotic Panniculopathy (Cellulite): A Randomized Trial. Dermatol Surg. 2019 Aug;45(8):1047-1056.
  • 4: Hoy SM. Collagenase Clostridium histolyticum: A Review in Peyronie’s Disease. Clin Drug Investig. 2020 Jan;40(1):83-92.
  • 5: Cocci A, Russo GI, Salamanca JIM, Ralph D, Palmieri A, Mondaini N. The End of an Era: Withdrawal of Xiapex (Clostridium histolyticum Collagenase) from the European Market. Eur Urol. 2020 May;77(5):660-661.
  • 6: Smeraglia F, Del Buono A, Maffulli N. Collagenase clostridium histolyticum in Dupuytren’s contracture: a systematic review. Br Med Bull. 2016 Jun;118(1):149-58.
  • 7: Jensen CFS, Jacobsen FM, Quallich S, Fode M, Sønksen J, Malaeb BS, Ohl DA; CopMich Collaborative. Patient-reported outcomes from a single-centre prospective post-marketing study on Collagenase Clostridium histolyticum injections for Peyronie’s disease. Andrologia. 2020 Nov;52(10):e13733.
  • 8: Cook J, Waughtel J, Andreoni AR, Sakharpe A, Friedman DW. Collagenase Clostridium histolyticum for Dupuytren’s Contracture: Comparing Single and Concurrent Injections. Plast Reconstr Surg. 2019 Apr;143(4):782e-787e.
  • 9: Capece M, Arcaniolo D, Manfredi C, Palmieri A, Verze P, Fusco F, Longo N, Mirone V. Second cycle of intralesional Collagenase Clostridium histolyticum for Peyronie’s disease using the modified shortened protocol: Results from a retrospective analysis. Andrologia. 2020 Apr;52(3):e13527.
  • 10: Harvey N, Pearce I. At what cost is collagenase clostridium histolyticum viable for treating Peyronie’s disease in a public healthcare system? Andrology. 2020 Sep;8(5):1304-1311.

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    Blue Tiger Scientific is an independent third-party distributor of select products manufactured by Molecular Depot LLC. By purchasing from bluetigerscientific.com, you (“the Customer”) agree to the following terms, adapted from Molecular Depot’s original conditions:

    Product Use & Eligibility
    Products are for in vitro research use only (RUO). They are not intended for human or animal use, diagnosis, therapy, resale to consumers, or residential delivery. Sales are limited to verified business addresses.

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    MD 1000: Non-regulated use, no change notification

    MD 2000: Non-regulated use, limited change notification

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Product Resources:

Copy of Technical Specifications

FeatureDetails
Viewing Head Siedentopf type trinocular head, inclined at 30°, Interpupillary adjustment 53mm to 75mm, graduated diopter on left eyetube (30mm I.D. eyetubes)
Eyepieces SWH10X Widefield high eyepoint eyepiece, Field No. 22, tube O.D. 30.0 mm
Nosepiece Quintuple
Quintuple LWD Planachromat Phase 10x, 20x
Condenser TC Condenser N.A. 0.30, W.D. 73.0mm
Stage180mm(X) x 245mm(Y) plain stage with replaceable glass insert with 45mm opening, Glass Stage plate insert
IlluminationKoehler without iris, with phase slider, 3W LED
WarrantyLIMITED LIFETIME WARRANTY

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