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ANP (Human, 5-27) Chemicals Molecular Depot
ANP (Human, 5-27) Chemicals Molecular Depot

ANP (Human, 5-27)

$907.00

    Catalog Number: MDP0510 (500 ug)

    ANP (Human, 5-27) is a high quality ANP (Human, 5-27). This product has been used as molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request.

    Products are for in vitro research use only (RUO).

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ANP (Human, 5-27) – Catalog #MDP0510 (500 µg)

Catalog # MDP0510
Lot # Batch dependent
Expiration Batch dependent
Amount 500 µg
Sequence Ser-Ser-Cys-Phe-Gly-Gly-Arg-Met-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg (Disulfide bond between Cys7–Cys23)
Molecular Weight 2404.4 g/mol
Supplied As Powder
Applications Research-grade molecular tool for biochemical and immunological studies
Storage −20 °C
Grade Biotechnology grade; highly pure; prepared using Type I ultrapure water (resistivity >18 MΩ·cm) and 0.22 µm filtration

High-purity human Atrial Natriuretic Peptide (ANP, residues 5–27) for consistent biochemical research and physiological modeling. ANP (Human, 5–27) (Catalog #MDP0510) is an actively used peptide fragment representing amino acids 5–27 of the native hormone, vital for regulating cardiovascular homeostasis. This biotech-grade peptide—supplied as a powder—supports precise mechanistic studies in receptor binding, signaling assays, and physiological modeling of natriuretic pathways.

Featuring the full functional core and stabilized by an intramolecular disulfide bridge between Cys7 and Cys23, this A-form peptide retains biological activity while enabling streamlined assay development and standardization. Researchers trust its consistent purity and defined sequence to reproduce data across formats such as receptor affinity assays, signaling pathway screening, and in vivo modeling. Bulk supply is available to support extended studies or high-throughput screening initiatives.

Manufactured under rigorous biotech-grade protocols with ultrapure water and sterile filtration, and stored at −20 °C, this peptide ensures long-term stability and experimental fidelity. As with all Molecular Depot offerings, ANP (Human, 5–27) is for Research Use Only (RUO) and is not intended for diagnostic, therapeutic, or clinical applications.

Why researchers choose this product:

  • Authentic human ANP fragment with intact disulfide structure ensures biological relevance
  • Precise molecular weight and purity for reproducibility
  • Ideal for receptor binding, signaling studies, and cardiovascular modeling
  • Stable powder format supports easy handling and extended storage
  • Bulk scale available for expanding research workflows

Indication for Use:
This product is for Research Use Only (RUO). It is not intended for diagnostic, therapeutic, or clinical use.

References:

  • 1: Nakagawa Y, Nishikimi T, Kuwahara K. Atrial and brain natriuretic peptides: Hormones secreted from the heart Peptides. 2019 Jan;111:18-25.
  • 2: Rubattu S, Gallo G. The Natriuretic Peptides for Hypertension Treatment High Blood Press Cardiovasc Prev. 2022 Jan;29(1):15-21.
  • 3: Zheng Q, Li Y, Zhang D, Cui X, Dai K, Yang Y, Liu S, Tan J, Yan Q. ANP promotes proliferation and inhibits apoptosis of ovarian granulosa cells by NPRA/PGRMC1/EGFR complex and improves ovary functions of PCOS rats Cell Death Dis. 2017 Oct 26;8(10):e3145.
  • 4: Theilig F, Wu Q. ANP-induced signaling cascade and its implications in renal pathophysiology Am J Physiol Renal Physiol. 2015 May 15;308(10):F1047-55.
  • 5: Chen C, Zhang Y, Tao M, Zhao X, Feng Q, Fei X, Fu Y. Atrial Natriuretic Peptide Attenuates Colitis via Inhibition of the cGAS-STING Pathway in Colonic Epithelial Cells Int J Biol Sci. 2022 Feb 7;18(4):1737-1754.
  • 6: Hirsch JR, Meyer M, Forssmann WG. ANP and urodilatin: who is who in the kidney Eur J Med Res. 2006 Oct 27;11(10):447-54.
  • 7: Sugawara A, Nakao K, Morii N, Yamada T, Itoh H, Shiono S, Saito Y, Mukoyama M, Arai H, Nishimura K, et al. Synthesis of atrial natriuretic polypeptide in human failing hearts. Evidence for altered processing of atrial natriuretic polypeptide precursor and augmented synthesis of beta-human ANP J Clin Invest. 1988 Jun;81(6):1962-70.
  • 8: Itoh H, Nakao K, Sugawara A, Saito Y, Mukoyama M, Morii N, Yamada T, Shiono S, Arai H, Hosoda K, et al. Gamma-atrial natriuretic polypeptide (gamma ANP)-derived peptides in human plasma: cosecretion of N-terminal gamma ANP fragment and alpha ANP J Clin Endocrinol Metab. 1988 Sep;67(3):429-37.
  • 9: Matsuo A, Nagai-Okatani C, Nishigori M, Kangawa K, Minamino N. Natriuretic peptides in human heart: Novel insight into their molecular forms, functions, and diagnostic use Peptides. 2019 Jan;111:3-17.
  • 10: Therrien JP, Kim SM, Terunuma A, Qin Y, Tock CL, Pfützner W, Ohyama M, Schnermann J, Vogel JC. A gene therapy approach for long-term normalization of blood pressure in hypertensive mice by ANP-secreting human skin grafts Proc Natl Acad Sci U S A. 2010 Mar 16;107(11):5118-23.

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Product Resources:

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Copy of Technical Specifications

FeatureDetails
Viewing Head Siedentopf type trinocular head, inclined at 30°, Interpupillary adjustment 53mm to 75mm, graduated diopter on left eyetube (30mm I.D. eyetubes)
Eyepieces SWH10X Widefield high eyepoint eyepiece, Field No. 22, tube O.D. 30.0 mm
Nosepiece Quintuple
Quintuple LWD Planachromat Phase 10x, 20x
Condenser TC Condenser N.A. 0.30, W.D. 73.0mm
Stage180mm(X) x 245mm(Y) plain stage with replaceable glass insert with 45mm opening, Glass Stage plate insert
IlluminationKoehler without iris, with phase slider, 3W LED
WarrantyLIMITED LIFETIME WARRANTY

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