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High Rheumatoid Factor Positive Serum Serum & Plasma Molecular Depot
High Rheumatoid Factor Positive Serum Serum & Plasma Molecular Depot
High Rheumatoid Factor Positive Serum Serum & Plasma Molecular Depot
High Rheumatoid Factor Positive Serum Serum & Plasma Molecular Depot

High Rheumatoid Factor Positive Serum

$795.00

    Catalog Number: B2010861 (1 mL)

    High Rheumatoid Factor Positive Serum is human serum containing high levels (2500-4999 IU/mL) of Rheumatoid Factor antibodies (RF). Titer has been measured with the RF Latex method. No preservatives have been added. All units have tested negative for infectious agents at the single donor level. Available as single donor units or as pooled units. Custom bulk amounts of this product are available upon request.

    Products are for in vitro research use only (RUO).

    Live Inquiry about this product via:

    Email: info@bluetigerscientific.com

    Text/SMS: (833) 928-4437 Mon–Fri, (8 am – 8 pm PST)

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What's Included

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VR Headset

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2 Touch Controllers

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Charging Cable

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Power Adapter

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High Rheumatoid Factor Positive Serum. 7 different clones are available.

Clone Catalog #
> 25,000 IU/mL B2010861G
20,000-24,999 IU/mL B2010861F
15,000-19,999 IU/mL B2010861E
10,000- 14,999 IU/mL B2010861D
7,500-9,999 IU/mL B2010861C
5,000-7,499 IU/mL B2010861B
2,500-4,999 IU/mL B2010861A
Catalog number: B2010861G
B2010861F
B2010861E
B2010861D
B2010861C
B2010861B
B2010861A
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 1 mL
Molecular Weight or Concentration: na
Supplied as: Human serum
Applications: molecular tool for various interference studies
Storage: -20°C
Keywords: high RF, RF > 2500 IU/mL, high RF serum
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

This human serum sample contains elevated levels of rheumatoid factor (RF > 2500 IU/mL) and is designed for interference testing in immunoassays and serologic platforms. Rheumatoid factor is an autoantibody commonly associated with autoimmune conditions such as rheumatoid arthritis, and its presence can lead to false positives or assay interference in clinical diagnostics. This reagent enables developers to assess assay robustness and specificity in the presence of high RF concentrations.

Supplied in 1 mL aliquots and stored at –20°C, this biotechnology-grade serum is filtered through 0.22 µm membranes and prepared using Type I ultrapure water (resistivity >18 MΩ·cm). It is ideal for validating RF interference in chemiluminescent, ELISA, and lateral flow formats. Researchers and assay developers can use this material to simulate real-world autoimmune interference scenarios and optimize assay performance accordingly.

Key benefits:

  • Human serum with RF > 2500 IU/mL for interference testing
  • Supports validation of immunoassay specificity and robustness
  • Filtered and aliquoted for reproducibility and long-term storage
  • Compatible with ELISA, CLIA, and serologic platforms
  • Biotechnology grade; prepared in ultrapure water

Indication for Use:
This product is for Research Use Only (RUO). This product is not for administration to humans or animals. This product is not for human or veterinary diagnostic or therapeutic use.

References:
1: Rao DA, Gurish MF, Marshall JL, Slowikowski K, Fonseka CY, Liu Y, Donlin LT, Henderson LA, Wei K, Mizoguchi F, Teslovich NC, Weinblatt ME, Massarotti EM, Coblyn JS, Helfgott SM, Lee YC, Todd DJ, Bykerk VP, Goodman SM, Pernis AB, Ivashkiv LB, Karlson EW, Nigrovic PA, Filer A, Buckley CD, Lederer JA, Raychaudhuri S, Brenner MB. Pathologically expanded peripheral T helper cell subset drives B cells in rheumatoid arthritis Nature. 2017 Feb 1;542(7639):110-114.
2: Shi L, Hu F, Xu C, Zhu H, Qie D, Yuan C, Tao Y, Liu H. Plasma exchange successfully treated macrophage activation syndrome in rheumatoid factor-positive polyarticular juvenile idiopathic arthritis with co-existing pneumonia Int J Rheum Dis. 2018 May;21(5):1142-1145.
3: Bartlett DB, Willis LH, Slentz CA, Hoselton A, Kelly L, Huebner JL, Kraus VB, Moss J, Muehlbauer MJ, Spielmann G, Kraus WE, Lord JM, Huffman KM. Ten weeks of high-intensity interval walk training is associated with reduced disease activity and improved innate immune function in older adults with rheumatoid arthritis: a pilot study Arthritis Res Ther. 2018 Jun 14;20(1):127.
4: Fan W, Xu L, Xie L, Yang D, Liu X, Zhang J, Li Y, Yi C. Negative interference by rheumatoid factor of plasma B-type natriuretic peptide in chemiluminescent microparticle immunoassays PLoS One. 2014 Aug 21;9(8):e105304.
5: Taghadosi M, Samimi Z, Assar S, Salahshoor MR, Jalili C. Plasma Leptin Does Not Reflect the Effect of High Body Mass Index on Disease Activity in Rheumatoid Arthritis Immunol Invest. 2020 Feb;49(1-2):32-45.
6: Abildtrup M, Kingsley GH, Scott DL. Calprotectin as a biomarker for rheumatoid arthritis: a systematic review J Rheumatol. 2015 May;42(5):760-70.
7: Hughes-Austin JM, Deane KD, Giles JT, Derber LA, Zerbe GO, Dabelea DM, Sokolove J, Robinson WH, Holers VM, Norris JM. Plasma adiponectin levels are associated with circulating inflammatory cytokines in autoantibody positive first-degree relatives of rheumatoid arthritis patients PLoS One. 2018 Jun 25;13(6):e0199578.
8: Rantapää-Dahlqvist S, Boman K, Tarkowski A, Hallmans G. Up regulation of monocyte chemoattractant protein-1 expression in anti-citrulline antibody and immunoglobulin M rheumatoid factor positive subjects precedes onset of inflammatory response and development of overt rheumatoid arthritis Ann Rheum Dis. 2007 Jan;66(1):121-3.
9: Lovece S, Stern R, Kagen LJ. Effects of rheumatoid factor, antinuclear antibodies and plasma reagin on the serologic assay for Lyme disease J Rheumatol. 1991 Dec;18(12):1813-8.
10: Twomey JJ, Rossen RD, Lewis VM, Morgan AC, McCormick KJ. Rheumatoid factor positive plasma and humoral cytotoxicity to malignant melanoma Cancer. 1978 Apr;41(4):1307-12.

    Terms & Conditions

    Blue Tiger Scientific is an independent third-party distributor of select products manufactured by Molecular Depot LLC. By purchasing from bluetigerscientific.com, you (“the Customer”) agree to the following terms, adapted from Molecular Depot’s original conditions:

    Product Use & Eligibility
    Products are for in vitro research use only (RUO). They are not intended for human or animal use, diagnosis, therapy, resale to consumers, or residential delivery. Sales are limited to verified business addresses.

    Payment Terms
    All purchases are prepaid and non-refundable once confirmed. Pricing is in USD and subject to change without notice.

    Purchase Orders
    Confirmed orders are final and may not be canceled or refunded unless authorized in writing.

    Limitation of Liability
    Blue Tiger Scientific and Molecular Depot LLC are not responsible for any damages resulting from product use or misuse.

    Waiver of Claims
    By ordering, you waive all claims arising from use of Molecular Depot products.

    Shipping & Handling
    Shipping is calculated at checkout. A minimum 27% handling fee applies to each order.

    Delivery Estimates All delivery timelines are estimates and not guaranteed. FedEx service levels are subject to operational delays, weather disruptions, and regional restrictions.

    FedEx Pickup Cutoff Orders submitted after the daily FedEx pickup window may not ship until the next available pickup day.

    Shipping Exceptions FedEx may impose restrictions or delays due to package size, weight, destination, or service availability. Blue Tiger Scientific is not liable for delays beyond our control.

    Weekend & Holiday Handling Orders placed on weekends or holidays will be processed on the next business day.

    Returns & Refunds
    Returns must be requested within 30 days through Blue Tiger Scientific. Refunds are only issued for shipping errors or verified defects, and processed within 45 business days if approved. Customers are responsible for return shipping costs unless otherwise stated. Refunds will exclude original shipping fees paid at checkout.

    Warranty Disclaimer
    All products are provided "as-is" with no warranties. Warranty issues are handled by the manufacturer.

    Safety Guidelines
    Always consult the product’s SDS. Products must not be ingested, inhaled, or come into contact with skin or eyes unless specified.

    Legal Use Compliance
    Products must not be used in violation of any law—local, state, federal, or international.

    Accuracy of Orders
    Customers are responsible for verifying all order details before submission.

    Changes or Cancellations
    All changes must be in writing and approved. Cancellations may result in fees for materials, labor, or third-party costs.

    Quality System (MD Levels)
    Molecular Depot’s MD-Quality System includes:

    MD 1000: Non-regulated use, no change notification

    MD 2000: Non-regulated use, limited change notification

    MD 3000: Regulated use, enhanced quality standards

    Delivery & Claims
    Orders may ship in parts. Claims for shortages or defects must be submitted within 2 days of receipt. Delivery dates are estimates only.

    Extended Payment Terms
    Payment is due within 30 days unless agreed otherwise. A 5% weekly penalty applies to late payments. Blue Tiger Scientific reserves discretion on payment application.

    Retention of Title
    Ownership remains with Blue Tiger Scientific or Molecular Depot LLC until payment is complete. Goods must be stored separately and labeled until paid in full.

    Intellectual Property
    No rights to manufacturing processes or IP are transferred. Blue Tiger Scientific is not liable for IP-related claims.

    Force Majeure
    Neither party is liable for delays or failures caused by uncontrollable events (e.g., weather, regulations, supply disruptions).

    Manufacturing Access
    Product purchase does not grant access to proprietary manufacturing documents or methods.

    Resale Prohibition
    Products cannot be resold without written approval from Molecular Depot LLC. Blue Tiger Scientific enforces this restriction.

    Governing Law
    Terms are governed by California and U.S. law. All disputes fall under U.S. jurisdiction.

Product Resources:

Manual Manual
Brochure Brochure

Copy of Technical Specifications

FeatureDetails
Viewing Head Siedentopf type trinocular head, inclined at 30°, Interpupillary adjustment 53mm to 75mm, graduated diopter on left eyetube (30mm I.D. eyetubes)
Eyepieces SWH10X Widefield high eyepoint eyepiece, Field No. 22, tube O.D. 30.0 mm
Nosepiece Quintuple
Quintuple LWD Planachromat Phase 10x, 20x
Condenser TC Condenser N.A. 0.30, W.D. 73.0mm
Stage180mm(X) x 245mm(Y) plain stage with replaceable glass insert with 45mm opening, Glass Stage plate insert
IlluminationKoehler without iris, with phase slider, 3W LED
WarrantyLIMITED LIFETIME WARRANTY

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