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IRAK-4 Peptide Substrate Chemicals Molecular Depot
IRAK-4 Peptide Substrate Chemicals Molecular Depot
IRAK-4 Peptide Substrate Chemicals Molecular Depot
IRAK-4 Peptide Substrate Chemicals Molecular Depot

IRAK-4 Peptide Substrate

$1,195.00

    Catalog Number: B2011450 (1 mg)

    IRAK-4 Peptide Substrate is a high quality substrate peptide for Interleukin-1 Receptor-Associated Kinase (IRAK) 4. This product has been used as molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request.

    Products are for in vitro research use only (RUO).

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What's Included

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VR Headset

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2 Touch Controllers

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Charging Cable

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Power Adapter

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IRAK-4 Peptide Substrate

Catalog number: B2011450
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 1 mg
Molecular Weight or Concentration: 2285.7 g/mol
Supplied as: Lyophilized
Applications: molecular tool for various biochemical applications
Storage: -20 °C
Keywords: IRAK-4 Peptide Substrate; IRAK-1 (360-380)
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References

  • Wang Z, Liu J, Sudom A, Ayres M, Li S, Wesche H, Powers JP, Walker NP. Crystal structures of IRAK-4 kinase in complex with inhibitors: a serine/threonine kinase with tyrosine as a gatekeeper Structure. 2006 Dec;14(12):1835-44.
  • Hekmat-Nejad M, Cai T, Swinney DC. Steady-state kinetic characterization of kinase activity and requirements for Mg2+ of interleukin-1 receptor-associated kinase-4 Biochemistry. 2010 Feb 23;49(7):1495-506.
  • Böl GF, Jurrmann N, Brigelius-Flohé R. Cellular trafficking of the IL-1RI-associated kinase-1 requires intact kinase activity Biochem Biophys Res Commun. 2005 Jun 24;332(1):279-87.
  • Dunne A, Carpenter S, Brikos C, Gray P, Strelow A, Wesche H, Morrice N, O’Neill LA. IRAK1 and IRAK4 promote phosphorylation, ubiquitination, and degradation of MyD88 adaptor-like (Mal) J Biol Chem. 2010 Jun 11;285(24):18276-82.
  • Vollmer S, Strickson S, Zhang T, Gray N, Lee KL, Rao VR, Cohen P. The mechanism of activation of IRAK1 and IRAK4 by interleukin-1 and Toll-like receptor agonists Biochem J. 2017 Jun 6;474(12):2027-2038.
  • Zhang G, Ghosh S. Negative regulation of toll-like receptor-mediated signaling by Tollip J Biol Chem. 2002 Mar 1;277(9):7059-65.
  • Kim JA, Yeh DC, Ver M, Li Y, Carranza A, Conrads TP, Veenstra TD, Harrington MA, Quon MJ. Phosphorylation of Ser24 in the pleckstrin homology domain of insulin receptor substrate-1 by Mouse Pelle-like kinase/interleukin-1 receptor-associated kinase: cross-talk between inflammatory signaling and insulin signaling that may contribute to insulin resistance J Biol Chem. 2005 Jun 17;280(24):23173-83.
  • Hazeki K, Masuda N, Funami K, Sukenobu N, Matsumoto M, Akira S, Takeda K, Seya T, Hazeki O. Toll-like receptor-mediated tyrosine phosphorylation of paxillin via MyD88-dependent and -independent pathways Eur J Immunol. 2003 Mar;33(3):740-7.
  • Wan YS, Wang ZQ, Voorhees J, Fisher G. EGF receptor crosstalks with cytokine receptors leading to the activation of c-Jun kinase in response to UV irradiation in human keratinocytes Cell Signal. 2001 Feb;13(2):139-44.

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    Product Use & Eligibility
    Products are for in vitro research use only (RUO). They are not intended for human or animal use, diagnosis, therapy, resale to consumers, or residential delivery. Sales are limited to verified business addresses.

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Product Resources:

Manual Manual
Brochure Brochure

Copy of Technical Specifications

FeatureDetails
Viewing Head Siedentopf type trinocular head, inclined at 30°, Interpupillary adjustment 53mm to 75mm, graduated diopter on left eyetube (30mm I.D. eyetubes)
Eyepieces SWH10X Widefield high eyepoint eyepiece, Field No. 22, tube O.D. 30.0 mm
Nosepiece Quintuple
Quintuple LWD Planachromat Phase 10x, 20x
Condenser TC Condenser N.A. 0.30, W.D. 73.0mm
Stage180mm(X) x 245mm(Y) plain stage with replaceable glass insert with 45mm opening, Glass Stage plate insert
IlluminationKoehler without iris, with phase slider, 3W LED
WarrantyLIMITED LIFETIME WARRANTY

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