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N-Palmitoyl-D-sphingosine (Highly Pure) Chemicals Molecular Depot
N-Palmitoyl-D-sphingosine (Highly Pure) Chemicals Molecular Depot
N-Palmitoyl-D-sphingosine (Highly Pure) Chemicals Molecular Depot
N-Palmitoyl-D-sphingosine (Highly Pure) Chemicals Molecular Depot

N-Palmitoyl-D-sphingosine (Highly Pure)

$1,595.00

    Catalog Number: B2018153 (10 mg)

    N-Palmitoyl-D-sphingosine, also known as ceramide, is a type of lipid molecule that plays a key role in various cellular functions, including cell signaling, cell growth, and apoptosis. Ceramides are important components of cell membranes. They are also implicated in various physiological processes and are considered important mediators in inflammation and immune responses. This product has been used as a molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request.

    Products are for in vitro research use only (RUO).

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N-Palmitoyl-D-sphingosine (Highly Pure) – Catalog #B2018153 (10 mg)

Catalog # B2018153
Lot # Batch dependent
Expiration Batch dependent
Amount 10 mg
Molecular Weight 537.9 g/mol
Supplied As Powder
Applications Molecular tool for various biochemical applications
Storage −20 °C
Keywords Cer(d18:1/16:0), (2S,3R,4E)-2-(Palmitoylamino)-4-octadecene-1,3-diol, N-Hexadecanoyl-D-sphingosine, N-Palmitoyl-D-erythro-sphingosine, N-[(1S,2R,3E)-2-Hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]hexadecanamide, C16 Ceramide (d18:1/16:0), C16-Ceramide
Grade Biotechnology grade; all products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ·cm) and are filtered through 0.22 µm.

High-purity ceramide (C16) native lipid for probing cell signaling, apoptosis, and membrane dynamics. N-Palmitoyl-D-sphingosine, commonly known as ceramide (C16 ceramide), is a central sphingolipid mediator with pivotal roles in cell signaling, growth regulation, and programmed cell death. Supplied as a lyophilized, biotechnology-grade powder, this molecule enables reliable use in immunobiological and biochemical workflows that require precise manipulation of ceramide levels, including inflammation, immune response, and apoptotic modeling.

As a key component of cellular membranes, ceramide mediates signaling via lipid rafts, contributes to stress response pathways, and serves as a biomarker in metabolic disorders and neoplastic progression. Due to its defined chemical structure and high purity, this ceramide variant supports quantitative lipidomics, lipid-enzyme interaction studies, and membrane structural analyses. Custom bulk quantities are available to support projects requiring extended access or scalability.

Formulated with consistent batch quality under biotech-grade conditions and stored at –20 °C, this product offers durable stability and reproducibility. It is strictly for Research Use Only (RUO)—not for therapeutic, diagnostic, or clinical use.

Why researchers choose this product:

  • Authentic C16 ceramide, enabling controlled investigation into sphingolipid signaling
  • High purity and biotech-grade production ensure reproducibility and low background
  • Stable powder format ideal for lipidomics and biochemistry workflows
  • Applicable in apoptosis, inflammation, membrane structure, and metabolic studies
  • Bulk availability supports long-term and high-throughput research continuity

Indication for Use:
This product is for Research Use Only (RUO). It is not intended for diagnostic, therapeutic, or clinical applications.

References:

  • 1: Yamane M. Simultaneous quantitative determination method for ceramide species from crude cellular extracts by high-performance liquid chromatography-thermospray mass spectrometry J Chromatogr B Analyt Technol Biomed Life Sci. 2003 Jan 5;783(1):181-90.
  • 2: Schmelz EM, Bushnev AS, Dillehay DL, Sullards MC, Liotta DC, Merrill AH Jr. Ceramide-beta-D-glucuronide: synthesis, digestion, and suppression of early markers of colon carcinogenesis Cancer Res. 1999 Nov 15;59(22):5768-72.
  • 3: Meeusen JW, Donato LJ, Bryant SC, Baudhuin LM, Berger PB, Jaffe AS. Plasma Ceramides Arterioscler Thromb Vasc Biol. 2018 Aug;38(8):1933-1939.
  • 4: Bibel DJ, Aly R, Shinefield HR. Antimicrobial activity of sphingosines J Invest Dermatol. 1992 Mar;98(3):269-73.
  • 5: Brief E, Kwak S, Cheng JT, Kitson N, Thewalt J, Lafleur M. Phase behavior of an equimolar mixture of N-palmitoyl-D-erythro-sphingosine, cholesterol, and palmitic acid, a mixture with optimized hydrophobic matching Langmuir. 2009 Jul 7;25(13):7523-32.
  • 6: Weis AL. New approaches to synthesis of stereospecific sphingomyelin Chem Phys Lipids. 1999 Nov;102(1-2):3-12.
  • 7: Dong Z, Butcher JA Jr. An efficient route to N-palmitoyl-D-erythro-sphingomyelin and its 13C-labeled derivatives Chem Phys Lipids. 1993 Nov;66(1-2):41-6.
  • 8: Neitchev V, Kostova E, Dimitrov AS. Importance of interfacial water in permeabilization of ceramide bilayers Histol Histopathol. 1998 Jul;13(3):911-20.
  • 9: Perera MN, Ganesan V, Siskind LJ, Szulc ZM, Bielawska A, Bittman R, Colombini M. Ceramide channel: Structural basis for selective membrane targeting Chem Phys Lipids. 2016 Jan;194:110-116.
  • 10: Yamane M. Palmitoyl-ceramide accumulation with necrotic cell death in A549 cells, followed by a steep increase in sphinganine content Biochim Open. 2015 Jun 21;1:11-27.

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Product Resources:

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Copy of Technical Specifications

FeatureDetails
Viewing Head Siedentopf type trinocular head, inclined at 30°, Interpupillary adjustment 53mm to 75mm, graduated diopter on left eyetube (30mm I.D. eyetubes)
Eyepieces SWH10X Widefield high eyepoint eyepiece, Field No. 22, tube O.D. 30.0 mm
Nosepiece Quintuple
Quintuple LWD Planachromat Phase 10x, 20x
Condenser TC Condenser N.A. 0.30, W.D. 73.0mm
Stage180mm(X) x 245mm(Y) plain stage with replaceable glass insert with 45mm opening, Glass Stage plate insert
IlluminationKoehler without iris, with phase slider, 3W LED
WarrantyLIMITED LIFETIME WARRANTY

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