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Palmitic Acid 9-hydroxy-stearic-acid Chemicals Molecular Depot
Palmitic Acid 9-hydroxy-stearic-acid Chemicals Molecular Depot
Palmitic Acid 9-hydroxy-stearic-acid Chemicals Molecular Depot
Palmitic Acid 9-hydroxy-stearic-acid Chemicals Molecular Depot

Palmitic Acid 9-hydroxy-stearic-acid

$2,395.00

    Catalog Number: B2017917 (100 mg)

    Palmitic-acid-9-hydroxy-stearic-acid is a compound formed by the esterification of palmitic acid and 9-hydroxy-stearic acid. It is a type of fatty acid derivative that can be found in various natural sources, including plants and animals This product has been used as a molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request.

    Products are for in vitro research use only (RUO).

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VR Headset

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Palmitic-Acid-9-Hydroxy-Stearic-Acid (PAHSA) – Catalog #B2017917 (100 mg)

Catalog # B2017917
Lot # Batch dependent
Expiration Batch dependent
Amount 100 mg
Molecular Weight 538.89 g/mol
Supplied As Powder
Applications Molecular tool for diverse biochemical and immunological applications
Storage 2–8 °C
Grade Biotechnology grade; all solutions made with Type I ultrapure water (>18 MΩ·cm) and filtered through 0.22 µm
Keywords 9-PAHSA, Palmitic Acid Ester of 9-Hydroxystearic Acid, FAHFA

Naturally occurring fatty acid ester with potent metabolic signaling and anti-inflammatory properties. Palmitic-Acid-9-Hydroxy-Stearic-Acid (PAHSA) – Catalog #B2017917 (100 mg) is a biologically relevant lipid molecule belonging to the FAHFA family (Fatty Acid Esters of Hydroxy Fatty Acids). Endogenously synthesized in mammals, PAHSA has garnered interest due to its role in modulating glucose homeostasis, insulin sensitivity, and inflammatory pathways. As a high-purity, biotechnology-grade molecular tool, this compound empowers researchers to explore metabolic regulation, signal transduction, and immunometabolic interactions with precision.

PAHSA's dual functional significance spans metabolic and inflammatory research. It has been demonstrated to enhance insulin-dependent glucose uptake and to regulate GPR40-mediated pathways that influence systemic metabolism. Its utility extends to studying oxidative stress, lipid signaling, and cellular stress responses in disease models, enabling both in vitro and in vivo investigations. The product’s lyophilized powder format ensures long-term stability and easy handling, while storage at 2–8 °C maintains molecular integrity for sensitive protocols.

Manufactured to stringent biotech standards—including use of ultrapure water and microfiltration—this PAHSA reagent delivers low-background performance and consistent activity across batches. Researchers focusing on diabetes, obesity, inflammation, cardiovascular disease, or neurodegeneration will find PAHSA an invaluable molecule for probing lipid-mediated signaling and therapeutic target validation. Custom bulk quantity options are available for long-term studies and high-throughput exploration of FAHFA biology.

Why researchers choose this product:

  • Endogenous lipid with defined anti-inflammatory and glucose-regulating activity
  • High-purity biotech-grade preparation supports reproducible metabolic assays
  • Stable powder form allows precise dosing and workflow flexibility
  • Relevant for diverse applications: signaling, insulin sensitivity, FAHFA biology
  • Custom bulk options support continuity in large-scale experiments

Indication for Use:
This product is for Research Use Only (RUO). It is not intended for diagnostic, therapeutic, or clinical applications.

References:

  • Yore MM, Syed I, Moraes-Vieira PM, Zhang T, Herman MA, Homan EA, Patel RT, Lee J, Chen S, Peroni OD, Dhaneshwar AS, Hammarstedt A, Smith U, McGraw TE, Saghatelian A, Kahn BB. Discovery of a class of endogenous mammalian lipids with anti-diabetic and anti-inflammatory effects. Cell. 2014 Oct 9;159(2):318-32.
  • Nelson AT, Kolar MJ, Chu Q, Syed I, Kahn BB, Saghatelian A, Siegel D. Stereochemistry of Endogenous Palmitic Acid Ester of 9-Hydroxystearic Acid and Relevance of Absolute Configuration to Regulation. J Am Chem Soc. 2017 Apr 5;139(13):4943-4947.
  • Brejchova K, Balas L, Paluchova V, Brezinova M, Durand T, Kuda O. Understanding FAHFAs: From structure to metabolic regulation. Prog Lipid Res. 2020 Jul;79:101053.
  • Kuda O, Brezinova M, Silhavy J, Landa V, Zidek V, Dodia C, Kreuchwig F, Vrbacky M, Balas L, Durand T, Hübner N, Fisher AB, Kopecky J. Nrf2-Mediated Antioxidant Defense and Peroxiredoxin 6 Are Linked to Biosynthesis of Palmitic Acid Ester of 9-Hydroxystearic Acid. Diabetes. 2018 Jun;67(6):1190-1199.
  • Rychtrmoc D, Staňková P, Kučera O, Červinková Z. Comparison of two anti-diabetic monoestolides regarding effects on intact murine liver tissue. Arch Physiol Biochem. 2022 Aug;128(4):985-992.
  • Xu X, Kang C, Sun R, Zuo YY. Biophysical properties of tear film lipid layer II. Polymorphism of FAHFA. Biophys J. 2022 Feb 1;121(3):451-458.
  • Aryal P, Syed I, Lee J, Patel R, Nelson AT, Siegel D, Saghatelian A. Distinct biological activities of isomers from several families of branched fatty acid esters of hydroxy fatty acids (FAHFAs). J Lipid Res. 2021;62.
  • Sokolowska P, Jastrzebska E, Dobrzyn A, Brzozka Z. Investigation of the Therapeutic Potential of New Antidiabetic Compounds Using Islet-on-a-Chip Microfluidic Model. Biosensors (Basel). 2022 May 5;12(5):302.
  • Wang JT, Wang XR, Ren JQ, Lin JH, Yu ZY, Huang SS, Hu Y, Fu JY, Wang M, Zhang YL, Wang XC, Guo JC, Xiao JC, Zhou HG. S-9-PAHSA’s neuroprotective effect mediated by CAIII suppresses apoptosis and oxidative stress in a mouse model of type 2 diabetes. CNS Neurosci Ther. 2024 Feb;30(2):e14594.
  • Syed I, Lee J, Moraes-Vieira PM, Donaldson CJ, Sontheimer A, Aryal P, Wellenstein K, Kolar MJ, Nelson AT, Siegel D, Mokrosinski J, Farooqi IS, Zhao JJ, Yore MM, Peroni OD, Saghatelian A, Kahn BB. Palmitic Acid Hydroxystearic Acids Activate GPR40, Which Is Involved in Their Beneficial Effects on Glucose Homeostasis. Cell Metab. 2018 Feb;27(2):419-427.e4.

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Product Resources:

Copy of Technical Specifications

FeatureDetails
Viewing Head Siedentopf type trinocular head, inclined at 30°, Interpupillary adjustment 53mm to 75mm, graduated diopter on left eyetube (30mm I.D. eyetubes)
Eyepieces SWH10X Widefield high eyepoint eyepiece, Field No. 22, tube O.D. 30.0 mm
Nosepiece Quintuple
Quintuple LWD Planachromat Phase 10x, 20x
Condenser TC Condenser N.A. 0.30, W.D. 73.0mm
Stage180mm(X) x 245mm(Y) plain stage with replaceable glass insert with 45mm opening, Glass Stage plate insert
IlluminationKoehler without iris, with phase slider, 3W LED
WarrantyLIMITED LIFETIME WARRANTY

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