Palmitic Acid 5-Hydroxy Stearic Acid (5-PAHSA) – Catalog #B2018192 (100 mg)

A highly pure lipid signaling molecule with distinctive neuroprotective and insulin-regulatory functions. Palmitic Acid 5-Hydroxy Stearic Acid (5-PAHSA) – Catalog #B2018192, supplied as a 100 mg powder, is a naturally occurring fatty acid ester recognized for its emerging role in metabolic and neurobiological research. Member of the FAHFA (Fatty Acid Esters of Hydroxy Fatty Acids) family, 5-PAHSA has been shown to exert neuroprotective effects by modulating the m-TOR–ULK1 autophagy pathway, making it a powerful tool for studying pathways of cellular stress response, neuroprotection, and metabolic regulation :contentReference[oaicite:2]{index=2}.

This versatile molecule enables researchers to explore a wide range of applications—spanning insulin secretion assays, single-islet microfluidics, signaling pathway modulation, and metabolic profiling. The powder format ensures long-term stability and precise dosing, while storage at 2–8 °C ensures molecular integrity. Manufacturing under biotechnology-grade standards—including ultrapure water and microfiltration—guarantees reproducibility and minimal background interference, essential for sensitive downstream assays :contentReference[oaicite:3]{index=3}.

In neurobiological contexts, 5-PAHSA’s inhibition of m-TOR–ULK1 phosphorylation positions it as a compelling candidate for neuroprotective strategy development—particularly in neurodegenerative disease models and autophagy-related therapies. In metabolic biology, its enhancement of insulin release—as measured in microfluidic platforms analyzing single islets—underscores its relevance in diabetes and endocrinology research :contentReference[oaicite:4]{index=4}. Custom bulk quantities are available to support extended research efforts and high-throughput screening pipelines.

Why researchers choose this product:

• Endogenous metabolite with demonstrated neuroprotective and insulin-regulating activity
• Purity and biotech-grade manufacturing support high-precision metabolic and signal pathway assays
• Stable powder format enables accurate dosing and long-term storage
• Supports diverse applications—including autophagy modulation and insulin secretion studies
• Bulk order options enable scalability for larger research programs

Indication for Use:
This product is for Research Use Only (RUO). It is not intended for diagnostic, therapeutic, or clinical use.

References:

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• 2: Wang JT, Yu ZY, Tao YH, Liu YC, Wang YM, Guo QL, Xue JZ, Wen XH, Zhang Q, Xu XD, He CF, Xue WJ, Guo JC, Zhou HG. A novel palmitic acid hydroxy stearic acid (5-PAHSA) plays a neuroprotective role by inhibiting phosphorylation of the m-TOR-ULK1 pathway and regulating autophagy. CNS Neurosci Ther. 2021 Apr;27(4):484-496.
• 3: Bandak B, Yi L, Roper MG. Microfluidic-enabled quantitative measurements of insulin release dynamics from single islets of Langerhans in response to 5-palmitic acid hydroxy stearic acid. Lab Chip. 2018 Sep 11;18(18):2873-2882.
• 4: Zrnzević I, Jovanović O, Zlatanović I, Stojanović I, Petrović G, Stojanović G. Constituents of Ramalina capitata (Ach.) Nyl. extracts. Nat Prod Res. 2017 Apr;31(7):857-860.
• 5: Liu Y, Chen M, Li Y, Feng X, Chen Y, Lin L. Analysis of Lipids in Green Coffee by Ultra-Performance Liquid Chromatography-Time-of-Flight Tandem Mass Spectrometry. Molecules. 2022 Aug 18;27(16):5271.
• 6: Vanithamani S, Akino Mercy CS, Kanagavel M, Sumaiya K, Bothammal P, Saranya P, Prasad M, Ponmurugan K, Muralitharan G, Al-Dhabi NA, Verma A, Vijayachari P, Natarajaseenivasan K. Biochemical analysis of leptospiral LPS explained the difference between pathogenic and non-pathogenic serogroups. Microb Pathog. 2021 Mar;152:104738.
• 7: Kellerer T, Kleigrewe K, Brandl B, Hofmann T, Hauner H, Skurk T. Fatty Acid Esters of Hydroxy Fatty Acids (FAHFAs) Are Associated With Diet, BMI, and Age. Front Nutr. 2021 Jul 12;8:691401.
• 8: Sokolowska P, Jastrzebska E, Dobrzyn A, Brzozka Z. Investigation of the Therapeutic Potential of New Antidiabetic Compounds Using Islet-on-a-Chip Microfluidic Model. Biosensors (Basel). 2022 May 5;12(5):302.