Bovine Serum

Versatile serum supplement for robust cell growth and reproducible RUO assays. Bovine Serum is a staple reagent for mammalian cell culture and a reliable additive in numerous biochemical and immunological workflows. Rich in growth factors, hormones, carrier proteins, lipids, and micronutrients, it enhances cell viability and expansion while buffering cells against mechanical and oxidative stress during routine handling. In assay development, bovine serum improves protein stability, reduces nonspecific binding as a blocker, and helps emulate complex biological matrices for more translatable results.

This serum integrates seamlessly with standard culture media and buffer systems used across academic, biotech, and industrial labs. Typical applications include supplementing basal media for maintenance and passaging, stabilizing enzymes and receptors in functional assays, and supporting protein–ligand interaction studies. Because serum composition can influence sensitive readouts, we recommend verifying optimal concentration for each cell line or assay. Batch documentation and storage guidance are provided to support experimental reproducibility and proper handling. For higher-throughput or scale-up needs, larger volumes are available on request to maintain lot consistency across projects.

Whether you are initiating new cultures, optimizing serum-dependent methods, or developing robust immunoassays, this bovine serum offers dependable performance for RUO applications. Pair it with defined supplements or specialty sera as needed to fine-tune growth kinetics, attachment, and assay sensitivity while maintaining consistent day-to-day results.

Why researchers choose this product:

• Nutrient-rich formulation that supports a wide range of mammalian cell lines
• Improves assay robustness by stabilizing proteins and reducing nonspecific interactions
• Compatible with common media and buffer systems; easy to integrate and optimize
• Batch documentation available to support reproducibility and QC
• Convenient research size; bulk options available for lot continuity

Indication for Use:
This product is for Research Use Only (RUO). It is not intended for human or animal administration, diagnostic procedures, or therapeutic applications.

References

• van der Valk J, Brunner D, De Smet K, Fex Svenningsen A, Honegger P, Knudsen LE, Lindl T, Noraberg J, Price A, Scarino ML, Gstraunthaler G. Optimization of chemically defined cell culture media–replacing fetal bovine serum in mammalian in vitro methods Toxicol In Vitro. 2010 Jun;24(4):1053-63.
• Heger JI, Froehlich K, Pastuschek J, Schmidt A, Baer C, Mrowka R, Backsch C, Schleuner E, Markert UR, Schmidt A. Human_serum alters cell culture behavior and improves spheroid formation in comparison to fetal bovine serum Exp Cell Res. 2018 Apr 1;365(1):57-65.
• Pietrowska M, Wlosowicz A, Gawin M, Widlak P. MS-Based Proteomic Analysis of Serum_ and Plasma: Problem of High Abundant Components and Lights and Shadows of Albumin Removal Adv Exp Med Biol. 2019;1073:57-76.
• Marcus-Sekura C, Richardson JC, Harston RK, Sane N, Sheets RL. Evaluation of the human host range of bovine_and porcine viruses that may contaminate bovine serum and porcine trypsin used in the manufacture of biological products Biologicals. 2011 Nov;39(6):359-69.
• Suzuki E, Urushidani T, Maeda S. Bovine serum promotes the formation and phenotype memory retention of persister cells in Escherichia coli liquid cultures World J Microbiol Biotechnol. 2021 Jun 1;37(7):110.
• Soto-Moreno EJ, Balboula A, Spinka C, Rivera RM. Serum supplementation during bovine_embryo culture affects their development and proliferation through macroautophagy and endoplasmic reticulum stress regulation PLoS One. 2021 Dec 9;16(12):e0260123.
• Robertson JS. Bovine_serum–regulatory issues Dev Biol (Basel). 2006;123:269-72; discussion 291-308.
• Pecora A, Prez L_pez J, Jordn MJ, Franco LN, Politzki R, Ruiz V, Alvarez I. Analysis of irradiated Argentinean fetal bovine_serum for adventitious agents J Vet Diagn Invest. 2020 Nov;32(6):892-897.
• Sadeghi M, Kapusinszky B, Yugo DM, Phan TG, Deng X, Kanevsky I, Opriessnig T, Woolums AR, Hurley DJ, Meng XJ, Delwart E. Virome of US bovine calf serum Biologicals. 2017 Mar;46:64-67.