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Thioredoxin Glutathione Reductase (Schistosoma mansoni) Proteins Molecular Depot
Thioredoxin Glutathione Reductase (Schistosoma mansoni) Proteins Molecular Depot
Thioredoxin Glutathione Reductase (Schistosoma mansoni) Proteins Molecular Depot
Thioredoxin Glutathione Reductase (Schistosoma mansoni) Proteins Molecular Depot

Thioredoxin Glutathione Reductase (Schistosoma mansoni)

$2,395.00

    Catalog Number: B2016748 (50 µg)

    Thioredoxin Glutathione Reductase (Schistosoma mansoni) is a high quality enzyme found in the parasite Schistosoma mansoni, which causes schistosomiasis in humans. TGR plays a crucial role in the antioxidant defense system of the parasite by maintaining the balance of thioredoxin and glutathione, two important molecules involved in redox reactions and protection against oxidative stress. This product has been used as a molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request.

    Products are for in vitro research use only (RUO).

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What's Included

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VR Headset

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2 Touch Controllers

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Charging Cable

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Power Adapter

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Thioredoxin Glutathione Reductase (Schistosoma mansoni)

Catalog number: B2016748
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 50 µg
Molecular Weight or Concentration: N/A
Supplied as: Solution
Applications: a molecular tool for various biochemical applications
Storage: −20°C
Keywords: TGR
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References

  • Song L, Li J, Xie S, Qian C, Wang J, Zhang W, Yin X, Hua Z, Yu C. Thioredoxin_glutathione_reductase as a novel drug target: evidence from Schistosoma japonicum PLoS One. 2012;7(2):e31456.
  • Kuntz AN, Davioud-Charvet E, Sayed AA, Califf LL, Dessolin J, Arnér ES, Williams DL. Thioredoxin_glutathione_reductase from Schistosoma_mansoni: an essential parasite enzyme and a key drug target PLoS Med. 2007 Jun;4(6):e206.
  • Alger HM, Williams DL. The disulfide redox system of Schistosoma_mansoni and the importance of a multifunctional enzyme, thioredoxin glutathione reductase Mol Biochem Parasitol. 2002 Apr 30;121(1):129-39.
  • Maggioli G, Silveira F, Martín-Alonso JM, Salinas G, Carmona C, Parra F. A recombinant thioredoxin-glutathione_reductase from Fasciola hepatica induces a protective response in rabbits Exp Parasitol. 2011 Dec;129(4):323-30.
  • Lea WA, Jadhav A, Rai G, Sayed AA, Cass CL, Inglese J, Williams DL, Austin CP, Simeonov A. A 1,536-well-based kinetic HTS assay for inhibitors of Schistosoma mansoni thioredoxin glutathione reductase Assay Drug Dev Technol. 2008 Aug;6(4):551-5.
  • Treger RS, Cook AG, Rai G, Maloney DJ, Simeonov A, Jadhav A, Thomas CJ, Williams DL, Cappello M, Vermeire JJ. Oxadiazole 2-oxides are toxic to the human hookworm, Ancylostoma ceylanicum, however glutathione_reductase is not the primary target Int J Parasitol Drugs Drug Resist. 2012 Dec 1;2:171-177.
  • Guglielmo S, Cortese D, Vottero F, Rolando B, Kommer VP, Williams DL, Fruttero R, Gasco A. New praziquantel derivatives containing NO-donor furoxans and related furazans as active agents against Schistosoma mansoni Eur J Med Chem. 2014 Sep 12;84:135-45.
  • Smith MM, Alt TB, Williams DL, Moran GR. Descriptive Analysis of Transient-State Observations for Thioredoxin/Glutathione Reductase (Sec597Cys) from Schistosoma_mansoni Biochemistry. 2023 May 2;62(9):1497-1508.
  • Petukhova VZ, Aboagye SY, Ardini M, Lullo RP, Fata F, Byrne ME, Gabriele F, Martin LM, Harding LNM, Gone V, Dangi B, Lantvit DD, Nikolic D, Ippoliti R, Effantin G, Ling WL, Johnson JJ, Thatcher GRJ, Angelucci F, Williams DL, Petukhov PA. Non-covalent inhibitors of thioredoxin_glutathione reductase with schistosomicidal activity in vivo Nat Commun. 2023 Jun 22;14(1):3737.

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Product Resources:

Copy of Technical Specifications

FeatureDetails
Viewing Head Siedentopf type trinocular head, inclined at 30°, Interpupillary adjustment 53mm to 75mm, graduated diopter on left eyetube (30mm I.D. eyetubes)
Eyepieces SWH10X Widefield high eyepoint eyepiece, Field No. 22, tube O.D. 30.0 mm
Nosepiece Quintuple
Quintuple LWD Planachromat Phase 10x, 20x
Condenser TC Condenser N.A. 0.30, W.D. 73.0mm
Stage180mm(X) x 245mm(Y) plain stage with replaceable glass insert with 45mm opening, Glass Stage plate insert
IlluminationKoehler without iris, with phase slider, 3W LED
WarrantyLIMITED LIFETIME WARRANTY

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