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Tankyrase 2 [849-1166] Active Human Proteins Molecular Depot
Tankyrase 2 [849-1166] Active Human Proteins Molecular Depot
Tankyrase 2 [849-1166] Active Human Proteins Molecular Depot
Tankyrase 2 [849-1166] Active Human Proteins Molecular Depot

Tankyrase 2 [849-1166] Active Human

$2,595.00

    Catalog Number: B2019692 (5 ug)

    Tankyrase 2, or TNKS2, is an enzyme involved in cellular processes like telomere length regulation and Wnt signaling. It modulates protein interactions through poly(ADP-ribosyl)ation and plays a role in DNA damage response, impacting genomic stability. Its active form catalyzes ADP-ribose addition to proteins, influencing their function. This product has been used as a molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request.

    Products are for in vitro research use only (RUO).

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What's Included

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VR Headset

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2 Touch Controllers

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Charging Cable

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Power Adapter

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Glasses Spacer

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Tankyrase 2 [849-1166] Active Human

Catalog number: B2019692
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 5 ug
Molecular Weight or Concentration: 62 kDa
Supplied as: Solution
Applications: a molecular tool for various biochemical applications
Storage: −70°C
Keywords: PARP5b, PARP5c, TNKS2, Tankyrase 2, poly(ADP-ribosyl)transferase 5b
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References

  • Szántó M, Gupte R, Kraus WL, Pacher P, Bai P. PARPs in lipid metabolism and related diseases Prog Lipid Res. 2021 Nov;84:101117.
  • Yao RQ, Ren C, Xia ZF, Yao YM. Organelle-specific autophagy in inflammatory diseases: a potential therapeutic target underlying the quality control of multiple organelles Autophagy. 2021 Feb;17(2):385-401.
  • Huang SM, Mishina YM, Liu S, Cheung A, Stegmeier F, Michaud GA, Charlat O, Wiellette E, Zhang Y, Wiessner S, Hild M, Shi X, Wilson CJ, Mickanin C, Myer V, Fazal A, Tomlinson R, Serluca F, Shao W, Cheng H, Shultz M, Rau C, Schirle M, Schlegl J, Ghidelli S, Fawell S, Lu C, Curtis D, Kirschner MW, Lengauer C, Finan PM, Tallarico JA, Bouwmeester T, Porter JA, Bauer A, Cong F. Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling Nature. 2009 Oct 1;461(7264):614-20.
  • Kim H, Villareal LB, Liu Z, Haneef M, Falcon DM, Martin DR, Lee HJ, Dame MK, Attili D, Chen Y, Varani J, Spence JR, Kovbasnjuk O, Colacino JA, Lyssiotis CA, Lin HC, Shah YM, Xue X. Transferrin Receptor-Mediated Iron Uptake Promotes Colon Tumorigenesis Adv Sci (Weinh). 2023 Apr;10(10):e2207693.
  • Hotta Y, Nishida K, Yoshida A, Nasu Y, Nakahara R, Naniwa S, Shimizu N, Ichikawa C, Lin D, Fujiwara T, Ozaki T. Inhibitory Effect of a Tankyrase Inhibitor on Mechanical Stress-Induced Protease Expression in Human Articular Chondrocytes Int J Mol Sci. 2024 Jan 24;25(3):1443.
  • Zimmerlin L, Zambidis ET. Pleiotropic roles of tankyrase/PARP proteins in the establishment and maintenance of human naïve pluripotency Exp Cell Res. 2020 May 1;390(1):111935.
  • Azarm K, Smith S. Nuclear PARPs and genome integrity Genes Dev. 2020 Mar 1;34(5-6):285-301.
  • Jessop M, Broadway BJ, Miller K, Guettler S. Regulation of PARP1/2 and the tankyrases: emerging parallels Biochem J. 2024 Sep 4;481(17):1097-1123.
  • Nkizinkiko Y, Desantis J, Koivunen J, Haikarainen T, Murthy S, Sancineto L, Massari S, Ianni F, Obaji E, Loza MI, Pihlajaniemi T, Brea J, Tabarrini O, Lehtiö L. 2-Phenylquinazolinones as dual-activity tankyrase-kinase inhibitors Sci Rep. 2018 Jan 26;8(1):1680.

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Product Resources:

Manual Manual
Brochure Brochure

Copy of Technical Specifications

FeatureDetails
Viewing Head Siedentopf type trinocular head, inclined at 30°, Interpupillary adjustment 53mm to 75mm, graduated diopter on left eyetube (30mm I.D. eyetubes)
Eyepieces SWH10X Widefield high eyepoint eyepiece, Field No. 22, tube O.D. 30.0 mm
Nosepiece Quintuple
Quintuple LWD Planachromat Phase 10x, 20x
Condenser TC Condenser N.A. 0.30, W.D. 73.0mm
Stage180mm(X) x 245mm(Y) plain stage with replaceable glass insert with 45mm opening, Glass Stage plate insert
IlluminationKoehler without iris, with phase slider, 3W LED
WarrantyLIMITED LIFETIME WARRANTY

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