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Rat Recombinant Thioredoxin Reductase 1 (aa 3-499) Proteins Molecular Depot
Rat Recombinant Thioredoxin Reductase 1 (aa 3-499) Proteins Molecular Depot
Rat Recombinant Thioredoxin Reductase 1 (aa 3-499) Proteins Molecular Depot
Rat Recombinant Thioredoxin Reductase 1 (aa 3-499) Proteins Molecular Depot

Rat Recombinant Thioredoxin Reductase 1 (aa 3-499)

$2,195.00

    Catalog Number: B2016937 (5 U)

    Rat Recombinant Thioredoxin Reductase 1 (aa 3-499) is a high quality enzyme that plays a key role in regulating cellular redox balance by catalyzing the reduction of thioredoxin, a small redox protein involved in various cellular processes. This product has been used as a molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request.

    Products are for in vitro research use only (RUO).

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What's Included

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VR Headset

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2 Touch Controllers

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Charging Cable

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Power Adapter

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Rat Recombinant Thioredoxin Reductase 1 (aa 3-499)

Catalog number: B2016937
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 5 U
Molecular Weight or Concentration: 54.5 kDa
Supplied as: Solution
Applications: a molecular tool for various biochemical applications
Storage: -80°C
Keywords: NADPH-dependent Thioredoxin Reductase, TrxR1, Txnrd1
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References

  • Cheng P, Liu H, Li Y, Pi P, Jiang Y, Zang S, Li X, Fu A, Ren X, Xu J, Holmgren A, Lu J. Inhibition of thioredoxin reductase 1 correlates with platinum-based chemotherapeutic induced tissue injury Biochem Pharmacol. 2020 May;175:113873.
  • Wang L, Yang Z, Fu J, Yin H, Xiong K, Tan Q, Jin H, Li J, Wang T, Tang W, Yin J, Cai G, Liu M, Kehr S, Becker K, Zeng H. Ethaselen: a potent mammalian thioredoxin reductase 1 inhibitor and novel organoselenium anticancer agent Free Radic Biol Med. 2012 Mar 1;52(5):898-908.
  • Dagnell M, Pace PE, Cheng Q, Frijhoff J, Östman A, Arnér ESJ, Hampton MB, Winterbourn CC. Thioredoxin reductase 1 and NADPH directly protect protein tyrosine phosphatase 1B from inactivation during H(2)O(2) exposure J Biol Chem. 2017 Sep 1;292(35):14371-14380.
  • Rengby O, Cheng Q, Vahter M, Jörnvall H, Arnér ES. Highly active dimeric and low-activity tetrameric forms of selenium-containing rat thioredoxin reductase 1 Free Radic Biol Med. 2009 Apr 1;46(7):893-904.
  • Cheng Q, Sandalova T, Lindqvist Y, Arnér ES. Crystal structure and catalysis of the selenoprotein thioredoxin reductase 1 J Biol Chem. 2009 Feb 6;284(6):3998-4008.
  • Engelman R, Ziv T, Arnér ESJ, Benhar M. Inhibitory nitrosylation of mammalian thioredoxin reductase 1: Molecular characterization and evidence for its functional role in cellular nitroso-redox imbalance Free Radic Biol Med. 2016 Aug;97:375-385.
  • Peng X, Zhang MQ, Conserva F, Hosny G, Selivanova G, Bykov VJ, Arnér ES, Wiman KG. APR-246/PRIMA-1MET inhibits thioredoxin reductase 1 and converts the enzyme to a dedicated NADPH oxidase Cell Death Dis. 2013 Oct 24;4(10):e881.
  • Gencheva R, Cheng Q, Arnér ESJ. Efficient selenocysteine-dependent reduction of toxoflavin by mammalian thioredoxin reductase Biochim Biophys Acta Gen Subj. 2018 Nov;1862(11):2511-2517.
  • Jovanović M, Zhukovsky D, Podolski-Renić A, Domračeva I, Žalubovskis R, Senćanski M, Glišić S, Sharoyko V, Tennikova T, Dar’in D, Pešić M, Krasavin M. Novel electrophilic amides amenable by the Ugi reaction perturb thioredoxin system via thioredoxin reductase 1 (TrxR1) inhibition: Identification of DVD-445 as a new lead compound for anticancer therapy Eur J Med Chem. 2019 Nov 1;181:111580.

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Product Resources:

Copy of Technical Specifications

FeatureDetails
Viewing Head Siedentopf type trinocular head, inclined at 30°, Interpupillary adjustment 53mm to 75mm, graduated diopter on left eyetube (30mm I.D. eyetubes)
Eyepieces SWH10X Widefield high eyepoint eyepiece, Field No. 22, tube O.D. 30.0 mm
Nosepiece Quintuple
Quintuple LWD Planachromat Phase 10x, 20x
Condenser TC Condenser N.A. 0.30, W.D. 73.0mm
Stage180mm(X) x 245mm(Y) plain stage with replaceable glass insert with 45mm opening, Glass Stage plate insert
IlluminationKoehler without iris, with phase slider, 3W LED
WarrantyLIMITED LIFETIME WARRANTY

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