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IRF3 (S386A, S396A mutant) Proteins Molecular Depot
IRF3 (S386A, S396A mutant) Proteins Molecular Depot

IRF3 (S386A, S396A mutant)

$2,195.00

    Catalog Number: B2017454 (100 µg)

    IRF3 (S386A, S396A mutant; human, recombinant) refers to a specific mutated form of the human Interferon Regulatory Factor 3 protein that has amino acid substitutions at positions 386 and 396. IRF3 is a transcription factor that plays a crucial role in the innate immune response by regulating the expression of genes involved in antiviral defense. This product has been used as a molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request.

    Products are for in vitro research use only (RUO).

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What's Included

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VR Headset

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2 Touch Controllers

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Charging Cable

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Power Adapter

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Glasses Spacer

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IRF3 (S386A, S396A mutant)

Catalog number: B2017454
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 100 µg
Molecular Weight or Concentration: 49.3 kDa
Supplied as: Solution
Applications: a molecular tool for various biochemical applications
Storage: -80°C
Keywords: IRF3 Negative Control
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References

  • Al Hamrashdi M, Brady G. Regulation of IRF3 activation in human antiviral signaling pathways Biochem Pharmacol. 2022 Jun;200:115026.
  • Tian M, Wang X, Sun J, Lin W, Chen L, Liu S, Wu X, Shi L, Xu P, Cai X, Wang X. IRF3 prevents colorectal tumorigenesis via inhibiting the nuclear translocation of β-catenin Nat Commun. 2020 Nov 13;11(1):5762.
  • Yan S, Kumari M, Xiao H, Jacobs C, Kochumon S, Jedrychowski M, Chouchani E, Ahmad R, Rosen ED. IRF3 reduces adipose thermogenesis via ISG15-mediated reprogramming of glycolysis J Clin Invest. 2021 Apr 1;131(7):e144888.
  • Dai T, Zhang L, Ran Y, Zhang M, Yang B, Lu H, Lin S, Zhang L, Zhou F. MAVS deSUMOylation by SENP1 inhibits its aggregation and antagonizes IRF3 activation Nat Struct Mol Biol. 2023 Jun;30(6):785-799.
  • King KR, Aguirre AD, Ye YX, Sun Y, Roh JD, Ng RP Jr, Kohler RH, Arlauckas SP, Iwamoto Y, Savol A, Sadreyev RI, Kelly M, Fitzgibbons TP, Fitzgerald KA, Mitchison T, Libby P, Nahrendorf M, Weissleder R. IRF3 and type I interferons fuel a fatal response to myocardial infarction Nat Med. 2017 Dec;23(12):1481-1487.
  • Tanaka Y, Chen ZJ. STING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathway Sci Signal. 2012 Mar 6;5(214):ra20.
  • Liu H, Ye G, Liu X, Xue M, Zhou Q, Zhang L, Zhang K, Huang L, Weng C. Vimentin inhibits type I interferon production by disrupting the TBK1-IKKε-IRF3 axis Cell Rep. 2022 Oct 11;41(2):111469.
  • Zhong B, Yang Y, Li S, Wang YY, Li Y, Diao F, Lei C, He X, Zhang L, Tien P, Shu HB. The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation Immunity. 2008 Oct 17;29(4):538-50.
  • Zhuang Y, Ortega-Ribera M, Thevkar Nagesh P, Joshi R, Huang H, Wang Y, Zivny A, Mehta J, Parikh SM, Szabo G. Bile acid-induced IRF3 phosphorylation mediates cell death, inflammatory responses, and fibrosis in cholestasis-induced liver and kidney injury via regulation of ZBP1 Hepatology. 2024 Apr 1;79(4):752-767.

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Product Resources:

Manual Manual
Brochure Brochure

Copy of Technical Specifications

FeatureDetails
Viewing Head Siedentopf type trinocular head, inclined at 30°, Interpupillary adjustment 53mm to 75mm, graduated diopter on left eyetube (30mm I.D. eyetubes)
Eyepieces SWH10X Widefield high eyepoint eyepiece, Field No. 22, tube O.D. 30.0 mm
Nosepiece Quintuple
Quintuple LWD Planachromat Phase 10x, 20x
Condenser TC Condenser N.A. 0.30, W.D. 73.0mm
Stage180mm(X) x 245mm(Y) plain stage with replaceable glass insert with 45mm opening, Glass Stage plate insert
IlluminationKoehler without iris, with phase slider, 3W LED
WarrantyLIMITED LIFETIME WARRANTY

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