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Human Recombinant K-Ras Isoform B (G12C, C51S, C80L, C118S mutant) Proteins Molecular Depot
Human Recombinant K-Ras Isoform B (G12C, C51S, C80L, C118S mutant) Proteins Molecular Depot

Human Recombinant K-Ras Isoform B (G12C, C51S, C80L, C118S mutant)

$1,795.00

    Catalog Number: B2017582 (50 µg)

    K-Ras Isoform B (G12C, C51S, C80L, C118S mutant; human, recombinant) is a variant of the K-Ras protein with mutations at specific amino acid positions. These mutations impact protein function and are relevant for cancer research due to their association with tumor growth and progression. It is used in studying mutation effects on signaling pathways. This product has been used as a molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request.

    Products are for in vitro research use only (RUO).

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What's Included

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VR Headset

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2 Touch Controllers

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Charging Cable

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Power Adapter

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Glasses Spacer

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Human Recombinant K-Ras Isoform B (G12C, C51S, C80L, C118S mutant)

Catalog number: B2017582
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 50 µg
Molecular Weight or Concentration: 22.27 kDa
Supplied as: SOLUTION
Applications: a molecular tool for various biochemical applications
Storage: -80°C
Keywords: c-K-ras(G12C, C51S, C80L, C118S), K-Ras4A(G12C, C51S, C80L, C118S), K-Ras Cys-light, Ki-Ras(G12C, C51S, C80L, C118S), c-Ki-ras(G12C, C51S, C80L, C118S), Kirsten Rat Sarcoma Virus(G12C, C51S, C80L, C118S)
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References

  • Cho KJ, van der Hoeven D, Zhou Y, Maekawa M, Ma X, Chen W, Fairn GD, Hancock JF. Inhibition of Acid Sphingomyelinase Depletes Cellular Phosphatidylserine and Mislocalizes K-Ras from the Plasma Membrane Mol Cell Biol. 2015 Nov 16;36(2):363-74.
  • Tsai FM, Shyu RY, Jiang SY. RIG1 inhibits the Ras/mitogen-activated protein kinase pathway by suppressing the activation of Ras Cell Signal. 2006 Mar;18(3):349-58.
  • Siljamäki E, Abankwa D. SPRED1 Interferes with K-ras but Not H-ras Membrane Anchorage and Signaling Mol Cell Biol. 2016 Sep 26;36(20):2612-25.
  • Nastasă C, Tamaian R, Oniga O, Tiperciuc B. 5-Arylidene(chromenyl-methylene)-thiazolidinediones: Potential New Agents against Mutant Oncoproteins K-Ras, N-Ras and B-Raf in Colorectal Cancer and Melanoma Medicina (Kaunas). 2019 Mar 31;55(4):85.
  • Nussinov R, Tsai CJ, Muratcioglu S, Jang H, Gursoy A, Keskin O. Principles of K-Ras effector organization and the role of oncogenic K-Ras in cancer initiation through G1 cell cycle deregulation Expert Rev Proteomics. 2015;12(6):669-82.
  • Pierro C, Cook SJ, Foets TC, Bootman MD, Roderick HL. Oncogenic K-Ras suppresses IP₃-dependent Ca²⁺ release through remodelling of the isoform composition of IP₃Rs and ER luminal Ca²⁺ levels in colorectal cancer cell lines J Cell Sci. 2014 Apr 1;127(Pt 7):1607-19.
  • Nussinov R, Jang H, Zhang M, Tsai CJ, Sablina AA. The Mystery of Rap1 Suppression of Oncogenic Ras Trends Cancer. 2020 May;6(5):369-379.
  • Nussinov R, Muratcioglu S, Tsai CJ, Jang H, Gursoy A, Keskin O. K-Ras4B/calmodulin/PI3Kα: A promising new adenocarcinoma-specific drug target? Expert Opin Ther Targets. 2016 Jul;20(7):831-42.
  • Liao J, Planchon SM, Wolfman JC, Wolfman A. Growth factor-dependent AKT activation and cell migration requires the function of c-K(B)-Ras versus other cellular ras isoforms J Biol Chem. 2006 Oct 6;281(40):29730-8.

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    Products are for in vitro research use only (RUO). They are not intended for human or animal use, diagnosis, therapy, resale to consumers, or residential delivery. Sales are limited to verified business addresses.

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Product Resources:

Manual Manual
Brochure Brochure

Copy of Technical Specifications

FeatureDetails
Viewing Head Siedentopf type trinocular head, inclined at 30°, Interpupillary adjustment 53mm to 75mm, graduated diopter on left eyetube (30mm I.D. eyetubes)
Eyepieces SWH10X Widefield high eyepoint eyepiece, Field No. 22, tube O.D. 30.0 mm
Nosepiece Quintuple
Quintuple LWD Planachromat Phase 10x, 20x
Condenser TC Condenser N.A. 0.30, W.D. 73.0mm
Stage180mm(X) x 245mm(Y) plain stage with replaceable glass insert with 45mm opening, Glass Stage plate insert
IlluminationKoehler without iris, with phase slider, 3W LED
WarrantyLIMITED LIFETIME WARRANTY

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