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Human alpha-Thrombin with Blocked DFP Active Site Proteins Molecular Depot
Human alpha-Thrombin with Blocked DFP Active Site Proteins Molecular Depot
Human alpha-Thrombin with Blocked DFP Active Site Proteins Molecular Depot
Human alpha-Thrombin with Blocked DFP Active Site Proteins Molecular Depot

Human alpha-Thrombin with Blocked DFP Active Site

$1,195.00

    Catalog Number: B2016614 (50 µg)

    Human alpha-Thrombin with Blocked DFP Active Site is a high quality modified form of the human alpha-thrombin enzyme where the active site has been specifically blocked or inhibited. Thrombin is a key enzyme in the blood clotting process, responsible for converting fibrinogen into fibrin to form blood clots. Blocking the active site of thrombin can be done for research purposes to study the enzyme’s function. This product has been used as a molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request.

    Products are for in vitro research use only (RUO).

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What's Included

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VR Headset

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2 Touch Controllers

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Charging Cable

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Power Adapter

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Human alpha-Thrombin with Blocked DFP Active Site

Catalog number: B2016614
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 50 µg
Molecular Weight or Concentration: 36700
Supplied as: Solution
Applications: a molecular tool for various biochemical applications
Storage: −20°C
Keywords: Human alpha-Thrombin, DFP active site blocked
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References

  • Sekine O, Sugo T, Ebisawa K, Umeyama H, Iwahana H, Ruiz-Sáez A, de Bosch N, Matsudai M. Substitution of Gly-548 to Ala in the substrate binding pocket of prothrombin Perijá leads to the loss of thrombin proteolytic activity Thromb Haemost. 2002 Feb;87(2):282-7.
  • Fenton JW 2nd, Bing DH. Thrombin active-site regions Semin Thromb Hemost. 1986 Jul;12(3):200-8.
  • Skrzypek E, Straley SC. Interaction between Yersinia pestis YopM protein and human alpha-thrombin Thromb Res. 1996 Oct 1;84(1):33-43.
  • Seiler SM. Thrombin receptor antagonists Semin Thromb Hemost. 1996;22(3):223-32.
  • Esmon CT. Regulation of blood coagulation Biochim Biophys Acta. 2000 Mar 7;1477(1-2):349-60.
  • Woodruff RS, Sullenger BA. Modulation of the Coagulation Cascade Using Aptamers Arterioscler Thromb Vasc Biol. 2015 Oct;35(10):2083-91.
  • Ye J, Esmon NL, Esmon CT, Johnson AE. The active site of thrombin is altered upon binding to thrombomodulin. Two distinct structural changes are detected by fluorescence, but only one correlates with protein C activation J Biol Chem. 1991 Dec 5;266(34):23016-21.
  • Rao LV, Ezban M. Active site-blocked activated factor VII as an effective antithrombotic agent: mechanism of action Blood Coagul Fibrinolysis. 2000 Apr;11 Suppl 1:S135-43.
  • Richardson JL, Fuentes-Prior P, Sadler JE, Huber R, Bode W. Characterization of the residues involved in the human alpha-thrombin-haemadin complex: an exosite II-binding inhibitor Biochemistry. 2002 Feb 26;41(8):2535-42.

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    Products are for in vitro research use only (RUO). They are not intended for human or animal use, diagnosis, therapy, resale to consumers, or residential delivery. Sales are limited to verified business addresses.

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Product Resources:

Copy of Technical Specifications

FeatureDetails
Viewing Head Siedentopf type trinocular head, inclined at 30°, Interpupillary adjustment 53mm to 75mm, graduated diopter on left eyetube (30mm I.D. eyetubes)
Eyepieces SWH10X Widefield high eyepoint eyepiece, Field No. 22, tube O.D. 30.0 mm
Nosepiece Quintuple
Quintuple LWD Planachromat Phase 10x, 20x
Condenser TC Condenser N.A. 0.30, W.D. 73.0mm
Stage180mm(X) x 245mm(Y) plain stage with replaceable glass insert with 45mm opening, Glass Stage plate insert
IlluminationKoehler without iris, with phase slider, 3W LED
WarrantyLIMITED LIFETIME WARRANTY

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