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GITR Extracellular Domain (human, recombinant) Proteins Molecular Depot
GITR Extracellular Domain (human, recombinant) Proteins Molecular Depot

GITR Extracellular Domain (human, recombinant)

$1,795.00

    Catalog Number: B2017354 (100 µg)

    GITR (Glucocorticoid-Induced TNFR-Related protein) is a member of the tumor necrosis factor receptor (TNFR) superfamily. The extracellular domain of GITR is the portion of the protein that is located outside the cell and is involved in binding to its ligands. Recombinant GITR extracellular domain can be used to study protein-protein interactions, and drug development. The recombinant form ensures a consistent and pure supply of the protein for experimental purposes. This product has been used as a molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request.

    Products are for in vitro research use only (RUO).

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What's Included

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VR Headset

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2 Touch Controllers

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Charging Cable

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Power Adapter

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GITR Extracellular Domain (human, recombinant)

Catalog number: B2017354
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 100 µg
Molecular Weight or Concentration: 16 kDa
Supplied as: Powder
Applications: a molecular tool for various biochemical applications
Storage: −80°C
Keywords: CD357, GITR-D, Glucocorticoid-induced TNFR-related Protein, TNF Receptor Superfamily Member 18, TNFRS18, Tumor Necrosis Factor Receptor Superfamily Member 18
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References

  • Tigue NJ, Bamber L, Andrews J, Ireland S, Hair J, Carter E, Sridharan S, Jovanović J, Rees DG, Springall JS, Solier E, Li YM, Chodorge M, Perez-Martinez D, Higazi DR, Oberst M, Kennedy M, Black CM, Yan L, Schwickart M, Maguire S, Cann JA, de Haan L, Young LL, Vaughan T, Wilkinson RW, Stewart R. MEDI1873, a potent, stabilized hexameric agonist of human GITR with regulatory T-cell targeting potential Oncoimmunology. 2017 Feb 3;6(3):e1280645.
  • Kim YH, Shin SM, Choi BK, Oh HS, Kim CH, Lee SJ, Kim KH, Lee DG, Park SH, Kwon BS. Authentic GITR Signaling Fails To Induce Tumor Regression unless Foxp3+ Regulatory T Cells Are Depleted J Immunol. 2015 Nov 15;195(10):4721-9.
  • Draghiciu O, Lubbers J, Nijman HW, Daemen T. Myeloid derived suppressor cells-An overview of combat strategies to increase immunotherapy efficacy Oncoimmunology. 2015 Feb 3;4(1):e954829.
  • Morillon YM 2nd, Hammond SA, Durham NM, Schlom J, Greiner JW. Enhanced immunotherapy by combining a vaccine with a novel murine GITR ligand fusion protein Oncotarget. 2017 Sep 7;8(43):73469-73482.
  • Nocentini G, Giunchi L, Ronchetti S, Krausz LT, Bartoli A, Moraca R, Migliorati G, Riccardi C. A new member of the tumor necrosis factor/nerve growth factor receptor family inhibits T cell receptor-induced apoptosis Proc Natl Acad Sci U S A. 1997 Jun 10;94(12):6216-21.
  • Zhou Z, Song X, Berezov A, Zhang G, Li Y, Zhang H, Murali R, Li B, Greene MI. Human glucocorticoid-induced TNF receptor ligand regulates its signaling activity through multiple oligomerization states Proc Natl Acad Sci U S A. 2008 Apr 8;105(14):5465-70.
  • Shin HH, Lee MH, Kim SG, Lee YH, Kwon BS, Choi HS. Recombinant glucocorticoid induced tumor necrosis factor receptor (rGITR) induces NOS in murine macrophage FEBS Lett. 2002 Mar 13;514(2-3):275-80.
  • Ko HJ, Kim YJ, Kim YS, Chang WS, Ko SY, Chang SY, Sakaguchi S, Kang CY. A combination of chemoimmunotherapies can efficiently break self-tolerance and induce antitumor immunity in a tolerogenic murine tumor model Cancer Res. 2007 Aug 1;67(15):7477-86.
  • Shen P, Su Z, Wang S, Xu H. [Bioinformatic analysis of mouse glucocorticoid-induced tumor necrosis factor receptor-related protein] Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2014 Nov;30(11):1205-8.

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    Products are for in vitro research use only (RUO). They are not intended for human or animal use, diagnosis, therapy, resale to consumers, or residential delivery. Sales are limited to verified business addresses.

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Product Resources:

Manual Manual
Brochure Brochure

Copy of Technical Specifications

FeatureDetails
Viewing Head Siedentopf type trinocular head, inclined at 30°, Interpupillary adjustment 53mm to 75mm, graduated diopter on left eyetube (30mm I.D. eyetubes)
Eyepieces SWH10X Widefield high eyepoint eyepiece, Field No. 22, tube O.D. 30.0 mm
Nosepiece Quintuple
Quintuple LWD Planachromat Phase 10x, 20x
Condenser TC Condenser N.A. 0.30, W.D. 73.0mm
Stage180mm(X) x 245mm(Y) plain stage with replaceable glass insert with 45mm opening, Glass Stage plate insert
IlluminationKoehler without iris, with phase slider, 3W LED
WarrantyLIMITED LIFETIME WARRANTY

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