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Collagen Type II from Calf Articular Joint FITC Proteins Molecular Depot
Collagen Type II from Calf Articular Joint FITC Proteins Molecular Depot
Collagen Type II from Calf Articular Joint FITC Proteins Molecular Depot
Collagen Type II from Calf Articular Joint FITC Proteins Molecular Depot

Collagen Type II from Calf Articular Joint FITC

$7,595.00

    Catalog Number: B2019001 (10 mg)

    Collagen Type II is an articular cartilage that plays a crucial role in providing structural support and elasticity to cartilage, making it essential for joint function and health. This product has been used as a molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request.

    Products are for in vitro research use only (RUO).

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Collagen Type II from Calf Articular Joint (FITC) – Catalog #B2019001 (10 mg)

Catalog # B2019001
Lot # Batch dependent
Expiration Batch dependent
Amount 10 mg
Molecular Weight / Concentration N/A
Supplied As Powder
Applications Molecular tool for biochemical and immunological applications
Storage RT
Grade Biotechnology grade; all solutions made with Type I ultrapure water (>18 MΩ·cm) and filtered through 0.22 µm
Keywords Collagen Type II, Calf Articular Joint, FITC

Fluorescently labeled collagen type II for precision tissue and extracellular matrix visualization. Collagen Type II from Calf Articular Joint, FITC-conjugated (Catalog #B2019001, 10 mg), is a high-purity, biotechnology-grade reagent designed for advanced biochemical and immunological applications requiring targeted fluorescent detection of cartilage matrix structures. FITC (fluorescein isothiocyanate) labeling enables sensitive visualization of type II collagen fibers in tissue sections, extracellular matrix preparations, and dynamic cell–matrix interaction assays, facilitating studies in cartilage biology, developmental modeling, and protease-mediated ECM remodeling.

Derived from calf joint articular cartilage, this reagent delivers authentic type II collagen conformation, preserving antigenicity for use in immunoassays, flow cytometry, and live-cell imaging. The FITC conjugate ensures high signal-to-noise fluorescence without compromising biochemical integrity. Researchers leverage this tool to monitor cartilage degradation, evaluate proteolytic enzyme activity in arthritis models, or validate tissue engineering scaffolds. The powder format and room-temperature storage simplify handling and integration into fluorescence-based protocols, while biotech-grade preparation ensures minimal contaminants and consistent batch-to-batch performance.

Manufactured with stringent quality controls using ultrapure water and microfiltration, the reagent supports reproducible results in RUO applications. Its FITC tag enables compatibility with standard fluorescence microscopy and flow cytometry workflows. Whether used for cartilage immunolabeling, ECM degradation assays, or development of quantitative collagenase-cleavage studies, this product enhances data fidelity and imaging clarity. Bulk quantities are available upon request, offering scalability for longitudinal studies and high-throughput platforms.

Why researchers choose this product:

  • FITC-conjugated type II collagen enables direct fluorescent detection of cartilage matrix
  • Authentic articular cartilage-derived collagen preserves native structural features
  • Powder form and RT storage enhance convenience and handling flexibility
  • Biotech-grade purification ensures low background and reproducible results
  • Ideal for imaging, immunoassays, ECM studies, and cartilage biology research workflows

Indication for Use:
This product is for Research Use Only (RUO). It is not intended for diagnostic, therapeutic, or clinical use.

References:

  • Mueller SM, Shortkroff S, Schneider TO, Breinan HA, Yannas IV, Spector M. Meniscus cells seeded in type I and type II collagen-GAG matrices in vitro. Biomaterials. 1999 Apr;20(8):701-9.
  • Logan AA, Nielsen BD, Manfredi JM, Robison CI. Sprint Exercise of Juvenile Animals Does Not Impact Cartilage Glycosaminoglycan or Synovial Fluid Neopeptide Collagenase Cleavage of Type I and II Collagen Content. J Equine Vet Sci. 2021 Jun;101:103405.
  • Mueller SM, Schneider TO, Shortkroff S, Breinan HA, Spector M. alpha-smooth muscle actin and contractile behavior of bovine meniscus cells seeded in type I and type II collagen-GAG matrices. J Biomed Mater Res. 1999 Jun 5;45(3):157-66.
  • Smith CB, Griffiths MM, Wei LS. Rat cytomegalovirus infection enhances type II collagen arthritis in rats. Arthritis Rheum. 1986 Oct;29(10):1263-8.
  • Henrotin Y, Bassleer C, Collette J, Nusgens B, Franchimont P. Radioimmunoassay for human type II collagen. J Immunoassay. 1990;11(4):555-78.
  • Ronzière MC, Berthet-Colominas C, Herbage D. Comparative structural studies of reconstituted and native type I and type II collagen fibrils by low-angle X-ray diffraction. Biochim Biophys Acta. 1987 Dec 18;916(3):381-7.
  • Chang C, Lauffenburger DA, Morales TI. Motile chondrocytes from newborn calf: migration properties and synthesis of collagen II. Osteoarthritis Cartilage. 2003 Aug;11(8):603-12.
  • Cheng T, Maddox NC, Wong AW, Rahnama R, Kuo AC. Comparison of gene expression patterns in articular cartilage and dedifferentiated articular chondrocytes. J Orthop Res. 2012 Feb;30(2):234-45.
  • Paglia LM, Wiestner M, Duchene M, Ouellette LA, Hörlein D, Martin GR, Müller PK. Effects of procollagen peptides on the translation of type II collagen messenger ribonucleic acid and on collagen biosynthesis in chondrocytes. Biochemistry. 1981 Jun 9;20(12):3523-7.
  • Shintani N, Kurth T, Hunziker EB. Expression of cartilage-related genes in bovine synovial tissue. J Orthop Res. 2007 Jun;25(6):813-9.

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Product Resources:

Copy of Technical Specifications

FeatureDetails
Viewing Head Siedentopf type trinocular head, inclined at 30°, Interpupillary adjustment 53mm to 75mm, graduated diopter on left eyetube (30mm I.D. eyetubes)
Eyepieces SWH10X Widefield high eyepoint eyepiece, Field No. 22, tube O.D. 30.0 mm
Nosepiece Quintuple
Quintuple LWD Planachromat Phase 10x, 20x
Condenser TC Condenser N.A. 0.30, W.D. 73.0mm
Stage180mm(X) x 245mm(Y) plain stage with replaceable glass insert with 45mm opening, Glass Stage plate insert
IlluminationKoehler without iris, with phase slider, 3W LED
WarrantyLIMITED LIFETIME WARRANTY

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