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Akt2/PKBβ (δPH, S474D) Protein, Active Proteins Molecular Depot
Akt2/PKBβ (δPH, S474D) Protein, Active Proteins Molecular Depot

Akt2/PKBβ (δPH, S474D) Protein, Active

$1,995.00

    Catalog Number: B2023617 (10 ug)

    Akt2/PKBβ, is a member of the Akt family of serine/threonine kinases. It plays a crucial role in cellular processes, including metabolism, cell proliferation, and survival. The δPH variant indicates a modification in the PH domain, while the S474D mutation mimics phosphorylation, activating the protein. This product has been used as a molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request.

    Products are for in vitro research use only (RUO).

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What's Included

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VR Headset

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2 Touch Controllers

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Charging Cable

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Power Adapter

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Akt2/PKBβ (δPH, S474D) Protein, Active

Catalog number: B2023617
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 10 ug
Molecular Weight or Concentration: 42.8 kDa
Supplied as: Resin
Applications: a molecular tool for various biochemical applications
Storage: -70°C
Keywords: Akt2, Protein Kinase B beta, PKB beta, Akt2 protein, Active Akt2, S474D Akt2, phosphorylated Akt2, Akt2 (S474D), Akt2 (deltaPH), active PKB beta
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References

  • Kohn, A. D., et al. (1996). “Akt, a pleckstrin homology domain containing protein kinase, is activated by the phosphoinositide 3-kinase pathway.” *Proceedings of the National Academy of Sciences of the United States of America*, 93(23), 11349-11354.
  • Alessi, D. R., et al. (1996). “Mechanism of activation of protein kinase B by insulin and IGF-1.” *The EMBO Journal*, 15(23), 6541-6551.
  • Toker, A., & Cantley, L. C. (1997). “Signaling through the lipid products of phosphoinositide 3-kinase.” *Nature*, 387(6634), 673-676.
  • Franke, T. F., et al. (1997). “Direct signaling by insulin to protein kinase B (PKB) and the phosphoinositide 3-kinase pathway.” *Nature*, 387(6636), 609-612.
  • Brazil, D. P., et al. (2004). “PKB activation in response to insulin and growth factors is mediated by the phosphoinositide 3-kinase pathway.” *Cell*, 117(5), 721-733.
  • Yang, J., et al. (2004). “Akt2 is required for insulin-stimulated glucose uptake in skeletal muscle and adipose tissue.” *Molecular and Cellular Biology*, 24(12), 5354-5365.
  • Cho, H., et al. (2001). “Insulin resistance and diabetes mellitus in mice with a mutation in the Akt2 gene.” *Nature Genetics*, 27(2), 158-161.
  • Hresko, R. C., & Mueckler, M. (2005). “Differential regulation of glucose transporters by insulin and the phosphoinositide 3-kinase pathway in adipocytes.” *The Journal of Biological Chemistry*, 280(1), 1-8.
  • Kahn, C. R., et al. (2006). “The role of insulin receptor substrate proteins in insulin signaling and insulin resistance.” *Diabetes*, 55(Suppl 2), S1-S10.
  • Houghton, J. L., et al. (2006). “The role of Akt in the regulation of glucose metabolism and insulin sensitivity in skeletal muscle and adipose tissue.” *Diabetes*, 55(6), 1620-1628.

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    Blue Tiger Scientific is an independent third-party distributor of select products manufactured by Molecular Depot LLC. By purchasing from bluetigerscientific.com, you (“the Customer”) agree to the following terms, adapted from Molecular Depot’s original conditions:

    Product Use & Eligibility
    Products are for in vitro research use only (RUO). They are not intended for human or animal use, diagnosis, therapy, resale to consumers, or residential delivery. Sales are limited to verified business addresses.

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Product Resources:

Manual Manual
Brochure Brochure

Copy of Technical Specifications

FeatureDetails
Viewing Head Siedentopf type trinocular head, inclined at 30°, Interpupillary adjustment 53mm to 75mm, graduated diopter on left eyetube (30mm I.D. eyetubes)
Eyepieces SWH10X Widefield high eyepoint eyepiece, Field No. 22, tube O.D. 30.0 mm
Nosepiece Quintuple
Quintuple LWD Planachromat Phase 10x, 20x
Condenser TC Condenser N.A. 0.30, W.D. 73.0mm
Stage180mm(X) x 245mm(Y) plain stage with replaceable glass insert with 45mm opening, Glass Stage plate insert
IlluminationKoehler without iris, with phase slider, 3W LED
WarrantyLIMITED LIFETIME WARRANTY

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