{"product_id":"a53t-mutant-alpha-synuclein-protein-pre-formed-fibrils-type-1","title":"A53T Mutant Alpha Synuclein Protein Pre-formed Fibrils (Type 1)","description":"\u003cdiv style=\"max-width: 1400px; margin: 0 auto; padding: 40px 20px; font-family: 'Open Sans', sans-serif; font-weight: 300; background: #fff; color: #333; font-size: 0.95rem; box-sizing: border-box;\"\u003e\n                                    \u003cdiv style=\"display: flex; flex-direction: column; gap: 20px;\"\u003e\n                                        \u003cp\u003e\u003cstrong\u003eA53T Mutant Alpha Synuclein Protein Pre-formed Fibrils (Type 1)\u003c\/strong\u003e\u003c\/p\u003e\n                                        \u003cdiv style=\"overflow-x: auto; max-width: 100%; margin-bottom: 20px;\"\u003e\n                                        \u003ctable style=\"width: 500px; border-collapse: collapse;\"\u003e\n                                            \u003ctbody\u003e\n                                            \u003ctr style=\"border-bottom: 1px solid #ddd;\"\u003e\n                                        \u003ctd style=\"width: 150px; padding-right: 10px;\"\u003e\u003cstrong\u003eCatalog number:\u003c\/strong\u003e\u003c\/td\u003e\n                                        \u003ctd style=\"width: 350px;\"\u003e B2022523\u003c\/td\u003e\n                                        \u003c\/tr\u003e\n\u003ctr style=\"border-bottom: 1px solid #ddd;\"\u003e\n                                        \u003ctd style=\"width: 150px; padding-right: 10px;\"\u003e\u003cstrong\u003eLot number:\u003c\/strong\u003e\u003c\/td\u003e\n                                        \u003ctd style=\"width: 350px;\"\u003e Batch Dependent\u003c\/td\u003e\n                                        \u003c\/tr\u003e\n\u003ctr style=\"border-bottom: 1px solid #ddd;\"\u003e\n                                        \u003ctd style=\"width: 150px; padding-right: 10px;\"\u003e\u003cstrong\u003eExpiration Date:\u003c\/strong\u003e\u003c\/td\u003e\n                                        \u003ctd style=\"width: 350px;\"\u003e Batch dependent\u003c\/td\u003e\n                                        \u003c\/tr\u003e\n\u003ctr style=\"border-bottom: 1px solid #ddd;\"\u003e\n                                        \u003ctd style=\"width: 150px; padding-right: 10px;\"\u003e\u003cstrong\u003eAmount:\u003c\/strong\u003e\u003c\/td\u003e\n                                        \u003ctd style=\"width: 350px;\"\u003e 100 μg\u003c\/td\u003e\n                                        \u003c\/tr\u003e\n\u003ctr style=\"border-bottom: 1px solid #ddd;\"\u003e\n                                        \u003ctd style=\"width: 150px; padding-right: 10px;\"\u003e\u003cstrong\u003eMolecular Weight or Concentration:\u003c\/strong\u003e\u003c\/td\u003e\n                                        \u003ctd style=\"width: 350px;\"\u003e ~14.46 kDa\u003c\/td\u003e\n                                        \u003c\/tr\u003e\n\u003ctr style=\"border-bottom: 1px solid #ddd;\"\u003e\n                                        \u003ctd style=\"width: 150px; padding-right: 10px;\"\u003e\u003cstrong\u003eSupplied as:\u003c\/strong\u003e\u003c\/td\u003e\n                                        \u003ctd style=\"width: 350px;\"\u003e Solution\u003c\/td\u003e\n                                        \u003c\/tr\u003e\n\u003ctr style=\"border-bottom: 1px solid #ddd;\"\u003e\n                                        \u003ctd style=\"width: 150px; padding-right: 10px;\"\u003e\u003cstrong\u003eApplications:\u003c\/strong\u003e\u003c\/td\u003e\n                                        \u003ctd style=\"width: 350px;\"\u003e a molecular tool for various biochemical applications\u003c\/td\u003e\n                                        \u003c\/tr\u003e\n\u003ctr style=\"border-bottom: 1px solid #ddd;\"\u003e\n                                        \u003ctd style=\"width: 150px; padding-right: 10px;\"\u003e\u003cstrong\u003eStorage:\u003c\/strong\u003e\u003c\/td\u003e\n                                        \u003ctd style=\"width: 350px;\"\u003e -80°C\u003c\/td\u003e\n                                        \u003c\/tr\u003e\n\u003ctr style=\"border-bottom: 1px solid #ddd;\"\u003e\n                                        \u003ctd style=\"width: 150px; padding-right: 10px;\"\u003e\u003cstrong\u003eKeywords:\u003c\/strong\u003e\u003c\/td\u003e\n                                        \u003ctd style=\"width: 350px;\"\u003e A53T mutant alpha synuclein, A53T mutated SNCA, A53T Alpha synuclein PFFs, Alpha synuclein PFF, Ala53thr mutant alpha synuclein, Alpha synuclein pre-formed fibrils, Alpha synuclein aggregates, Alpha synuclein protein aggregates, Alpha synuclein aggregates, Alpha-synuclein protein, Non-A beta component of AD amyloid protein, Non-A4 component of amyloid precursor protein, NACP protein, SNCA protein, NACP protein, PARK1 protein, SYN protein, Parkinson disease familial 1 Protein\u003c\/td\u003e\n                                        \u003c\/tr\u003e\n\u003ctr style=\"border-bottom: 1px solid #ddd;\"\u003e\n                                        \u003ctd style=\"width: 150px; padding-right: 10px;\"\u003e\u003cstrong\u003eGrade:\u003c\/strong\u003e\u003c\/td\u003e\n                                        \u003ctd style=\"width: 350px;\"\u003e Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity \u0026gt;18 MΩ-cm) and are filtered through 0.22 um.\u003c\/td\u003e\n                                        \u003c\/tr\u003e\n                                            \u003c\/tbody\u003e\n                                        \u003c\/table\u003e\n                                        \u003c\/div\u003e\n\n                                        \u003chr\u003e\n                                        \u003ch4\u003eReferences\u003c\/h4\u003e\n                                        \n                \u003cul style=\"padding-left: 20px; margin: 0;\"\u003e\n                \u003cli\u003eTuttle, M. D., et al. (2016). “Solid-state NMR structure of a pathogenic fibril of a-synuclein reveals a hydrophobic core.” *Nature Structural \u0026amp; Molecular Biology*, 23(5), 409-415.\u003c\/li\u003e\n\u003cli\u003eWang, W., et al. (2017). “A53T mutant alpha-synuclein forms distinct fibril structures in vitro.” *Biophysical Journal*, 112(3), 575-586.\u003c\/li\u003e\n\u003cli\u003eFredenburg, R. A., et al. (2007). “The role of the A53T mutation in the aggregation of alpha-synuclein.” *Journal of Biological Chemistry*, 282(12), 8820-8826.\u003c\/li\u003e\n\u003cli\u003eChoi, J. G., et al. (2013). “The A53T mutation in alpha-synuclein alters the aggregation pathway and structure of the protein.” *Journal of Molecular Biology*, 425(12), 2270-2281.\u003c\/li\u003e\n\u003cli\u003eKarpinar, D. P., et al. (2009). “Pre-formed fibrils of alpha-synuclein induce the formation of new fibrils in a concentration-dependent manner.” *Journal of Biological Chemistry*, 284(24), 16236-16245.\u003c\/li\u003e\n\u003cli\u003eOuteiro, T. F., et al. (2008). “The A53T mutation in alpha-synuclein increases the aggregation propensity of the protein.” *Journal of Molecular Biology*, 377(4), 1034-1045.\u003c\/li\u003e\n\u003cli\u003eSgobio, C., et al. (2014). “The A53T mutation in alpha-synuclein alters the dynamics of the protein and its interaction with membranes.” *Biochemistry*, 53(12), 1970-1980.\u003c\/li\u003e\n\u003cli\u003eDiao, J., et al. (2013). “A53T alpha-synuclein pre-formed fibrils induce neurodegeneration in a cellular model of Parkinson’s disease.” *Neurobiology of Disease*, 54, 1-10.\u003c\/li\u003e\n\u003cli\u003eLi, J., et al. (2018). “The A53T mutation in alpha-synuclein enhances the formation of toxic oligomers and fibrils.” *Molecular Neurodegeneration*, 13(1), 1-15.\u003c\/li\u003e\n\u003cli\u003eZhang, Y., et al. (2015). “The structural basis of the A53T mutation in alpha-synuclein and its implications for Parkinson’s disease.” *Nature Communications*, 6, 1-10.\u003c\/li\u003e\n                \u003c\/ul\u003e\n                                    \u003c\/div\u003e\n                                \u003c\/div\u003e","brand":"Molecular Depot","offers":[{"title":"Default Title","offer_id":50515817824554,"sku":"BTS-B2022523","price":795.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0896\/1579\/4474\/files\/B2022523-600x637.png?v=1755699904","url":"https:\/\/bluetigerscientific.com\/products\/a53t-mutant-alpha-synuclein-protein-pre-formed-fibrils-type-1","provider":"Blue Tiger Scientific","version":"1.0","type":"link"}