{"title":"Serum \u0026 Plasma","description":"","products":[{"product_id":"high-hama-serum-1","title":"High HAMA Serum","description":"\u003cdiv style=\"max-width:1400px; margin:0 auto; padding:40px 20px; font-family:'Open Sans',sans-serif; font-weight:300; background:#fff; color:#333; font-size:0.95rem; box-sizing:border-box;\"\u003e\n  \u003cdiv style=\"display:flex; flex-direction:column; gap:20px;\"\u003e\n\n    \u003ch2 style=\"margin:0; font-weight:600;\"\u003eHigh HAMA Serum – Research Use Only\u003c\/h2\u003e\n\n    \u003cp\u003e\n      High HAMA Serum is a biotechnology-grade \u003cstrong\u003ehuman serum interference testing reagent\u003c\/strong\u003e supplied as a \u003cstrong\u003e1 mL aliquot\u003c\/strong\u003e for research applications involving \u003cstrong\u003eimmunoassay validation, heterophilic antibody interference studies, and analytical robustness testing\u003c\/strong\u003e. This serum contains elevated levels of \u003cstrong\u003eHuman Anti-Mouse Antibodies (HAMA)\u003c\/strong\u003e, which are known to interfere with immunoassays that utilize murine monoclonal antibodies. It is especially useful in workflows related to \u003cstrong\u003eELISA, CLIA, biomarker quantitation, diagnostic assay development, and assay troubleshooting\u003c\/strong\u003e.\n    \u003c\/p\u003e\n\n    \u003c!-- SPEC TABLE --\u003e\n    \u003cdiv style=\"overflow-x:auto; max-width:100%; margin-bottom:20px;\"\u003e\n      \u003ctable style=\"width:500px; border-collapse:collapse;\"\u003e\n        \u003ctbody\u003e\n          \u003ctr style=\"border-bottom:1px solid #ddd;\"\u003e\n            \u003ctd style=\"width:180px;\"\u003e\u003cstrong\u003eCatalog #\u003c\/strong\u003e\u003c\/td\u003e\n            \u003ctd\u003eS2010006\u003c\/td\u003e\n          \u003c\/tr\u003e\n          \u003ctr style=\"border-bottom:1px solid #ddd;\"\u003e\n            \u003ctd\u003e\u003cstrong\u003eLot #\u003c\/strong\u003e\u003c\/td\u003e\n            \u003ctd\u003eBatch dependent\u003c\/td\u003e\n          \u003c\/tr\u003e\n          \u003ctr style=\"border-bottom:1px solid #ddd;\"\u003e\n            \u003ctd\u003e\u003cstrong\u003eExpiration Date\u003c\/strong\u003e\u003c\/td\u003e\n            \u003ctd\u003eBatch dependent\u003c\/td\u003e\n          \u003c\/tr\u003e\n          \u003ctr style=\"border-bottom:1px solid #ddd;\"\u003e\n            \u003ctd\u003e\u003cstrong\u003eVolume\u003c\/strong\u003e\u003c\/td\u003e\n            \u003ctd\u003e1 mL\u003c\/td\u003e\n          \u003c\/tr\u003e\n          \u003ctr style=\"border-bottom:1px solid #ddd;\"\u003e\n            \u003ctd\u003e\u003cstrong\u003eAppearance\u003c\/strong\u003e\u003c\/td\u003e\n            \u003ctd\u003eYellow orange\u003c\/td\u003e\n          \u003c\/tr\u003e\n          \u003ctr style=\"border-bottom:1px solid #ddd;\"\u003e\n            \u003ctd\u003e\u003cstrong\u003eMatrix\u003c\/strong\u003e\u003c\/td\u003e\n            \u003ctd\u003eHuman serum\u003c\/td\u003e\n          \u003c\/tr\u003e\n          \u003ctr style=\"border-bottom:1px solid #ddd;\"\u003e\n            \u003ctd\u003e\u003cstrong\u003eStorage\u003c\/strong\u003e\u003c\/td\u003e\n            \u003ctd\u003e-20°C or lower. Avoid repeated freeze-thaw cycles. Aliquot as needed.\u003c\/td\u003e\n          \u003c\/tr\u003e\n          \u003ctr style=\"border-bottom:1px solid #ddd;\"\u003e\n            \u003ctd\u003e\u003cstrong\u003eKeywords\u003c\/strong\u003e\u003c\/td\u003e\n            \u003ctd\u003eHAMA sample, Human Anti-Mouse Antibodies serum, High HAMA plasma\u003c\/td\u003e\n          \u003c\/tr\u003e\n        \u003c\/tbody\u003e\n      \u003c\/table\u003e\n    \u003c\/div\u003e\n\n    \u003c!-- SCIENTIFIC OVERVIEW --\u003e\n    \u003ch3\u003eScientific Overview\u003c\/h3\u003e\n    \u003cp\u003e\n      Human Anti-Mouse Antibodies (HAMA) are a well-documented source of \u003cstrong\u003eheterophilic antibody interference\u003c\/strong\u003e in immunoassays that rely on murine monoclonal antibodies. These antibodies can bind nonspecifically to assay components, leading to \u003cstrong\u003efalse-positive signals, altered binding kinetics, and inaccurate quantitation\u003c\/strong\u003e.\n    \u003c\/p\u003e\n    \u003cp\u003e\n      In laboratory and assay development settings, high HAMA serum is commonly used to evaluate \u003cstrong\u003eassay susceptibility to interference, blocking strategy effectiveness, and analytical reliability\u003c\/strong\u003e. It is particularly relevant in workflows involving \u003cstrong\u003etwo-site immunoassays, sandwich ELISAs, chemiluminescent assays, and biomarker detection systems\u003c\/strong\u003e.\n    \u003c\/p\u003e\n\n    \u003c!-- APPLICATIONS --\u003e\n    \u003ch3\u003eApplications\u003c\/h3\u003e\n    \u003cul style=\"padding-left:20px;\"\u003e\n      \u003cli\u003eImmunoassay interference testing and validation\u003c\/li\u003e\n      \u003cli\u003eHeterophilic antibody interference evaluation\u003c\/li\u003e\n      \u003cli\u003eELISA and CLIA assay development and troubleshooting\u003c\/li\u003e\n      \u003cli\u003eMatrix spiking and assay robustness studies\u003c\/li\u003e\n      \u003cli\u003eBlocking reagent validation and optimization workflows\u003c\/li\u003e\n    \u003c\/ul\u003e\n\n    \u003c!-- USAGE --\u003e\n    \u003ch3\u003eUsage \u0026amp; Handling Guidance\u003c\/h3\u003e\n    \u003cp\u003e\n      Store at -20°C or lower as specified. To preserve sample integrity, avoid repeated freeze-thaw cycles and aliquot upon first use if necessary. This serum may be used directly or diluted depending on the intended assay validation or interference testing protocol.\n    \u003c\/p\u003e\n    \u003cul style=\"padding-left:20px;\"\u003e\n      \u003cli\u003e\n\u003cstrong\u003ePreparation:\u003c\/strong\u003e Use directly or dilute into assay matrix as required\u003c\/li\u003e\n      \u003cli\u003e\n\u003cstrong\u003eHandling:\u003c\/strong\u003e Minimize freeze-thaw cycles to maintain consistency\u003c\/li\u003e\n      \u003cli\u003e\n\u003cstrong\u003eOptimization:\u003c\/strong\u003e Adjust spike levels based on assay sensitivity and interference design\u003c\/li\u003e\n      \u003cli\u003e\n\u003cstrong\u003eWorkflow note:\u003c\/strong\u003e Validate assay performance under HAMA-challenged conditions\u003c\/li\u003e\n    \u003c\/ul\u003e\n\n    \u003c!-- WHAT YOU GET --\u003e\n    \u003ch3\u003eWhat You Get\u003c\/h3\u003e\n    \u003cul style=\"padding-left:20px;\"\u003e\n      \u003cli\u003e1 mL High HAMA human serum sample\u003c\/li\u003e\n      \u003cli\u003eElevated HAMA levels for interference testing workflows\u003c\/li\u003e\n      \u003cli\u003eBiotechnology-grade material for assay validation\u003c\/li\u003e\n      \u003cli\u003eSuitable for ELISA, CLIA, and immunoassay systems\u003c\/li\u003e\n      \u003cli\u003eFor research use only (RUO)\u003c\/li\u003e\n    \u003c\/ul\u003e\n\n    \u003c!-- WHY --\u003e\n    \u003ch3\u003eWhy Researchers Choose It\u003c\/h3\u003e\n    \u003cul style=\"padding-left:20px;\"\u003e\n      \u003cli\u003eDesigned specifically for heterophilic antibody interference studies\u003c\/li\u003e\n      \u003cli\u003eSupports assay validation and robustness testing\u003c\/li\u003e\n      \u003cli\u003eRelevant to real-world immunoassay performance challenges\u003c\/li\u003e\n      \u003cli\u003eUseful for troubleshooting false positives and signal distortion\u003c\/li\u003e\n      \u003cli\u003eConvenient aliquot format for controlled experimental use\u003c\/li\u003e\n    \u003c\/ul\u003e\n\n    \u003c!-- FAQ --\u003e\n    \u003ch3\u003eFrequently Asked Questions (FAQ)\u003c\/h3\u003e\n    \u003cul style=\"padding-left:20px;\"\u003e\n      \u003cli\u003e\n\u003cstrong\u003eWhat is High HAMA Serum used for?\u003c\/strong\u003e\u003cbr\u003e\n        It is used for immunoassay interference testing, particularly to evaluate the impact of human anti-mouse antibodies on assay performance.\u003c\/li\u003e\n\n      \u003cli\u003e\n\u003cstrong\u003eWhy are HAMA antibodies important in assay development?\u003c\/strong\u003e\u003cbr\u003e\n        HAMA can bind nonspecifically to assay antibodies, causing false positives or altered signal behavior in immunoassays.\u003c\/li\u003e\n\n      \u003cli\u003e\n\u003cstrong\u003eWhat types of assays are affected by HAMA?\u003c\/strong\u003e\u003cbr\u003e\n        HAMA interference is especially relevant in ELISA, CLIA, sandwich immunoassays, and other antibody-based detection systems.\u003c\/li\u003e\n\n      \u003cli\u003e\n\u003cstrong\u003eHow should this product be handled?\u003c\/strong\u003e\u003cbr\u003e\n        Store frozen and avoid repeated freeze-thaw cycles. Aliquot if needed to maintain consistency across experiments.\u003c\/li\u003e\n\n      \u003cli\u003e\n\u003cstrong\u003eIs this product intended for diagnostic or clinical use?\u003c\/strong\u003e\u003cbr\u003e\n        No. This product is for Research Use Only (RUO) and is not intended for diagnostic or therapeutic applications.\u003c\/li\u003e\n    \u003c\/ul\u003e\n\n    \u003cdiv style=\"margin-top:20px; font-weight:bold; color:#c8102e;\"\u003e\n      This product is for Research Use Only (RUO). It is not intended for diagnostic or therapeutic use.\n    \u003c\/div\u003e\n\n    \u003chr\u003e\n\n    \u003c!-- REFERENCES (VERBATIM PRESERVED) --\u003e\n    \u003ch4\u003eReferences\u003c\/h4\u003e\n    \u003cul style=\"padding-left:20px; margin:0;\"\u003e\n      \u003cli\u003eReinsberg J. Different efficacy of various blocking reagents to eliminate interferences by human antimouse antibodies with a two-site immunoassay. \u003cem\u003eClin Biochem\u003c\/em\u003e. 1996 Apr;29(2):145-8.\u003c\/li\u003e\n      \u003cli\u003eBolstad N, Warren DJ, Nustad K. Heterophilic antibody interference in immunometric assays. \u003cem\u003eBest Pract Res Clin Endocrinol Metab\u003c\/em\u003e. 2013 Oct;27(5):647-61.\u003c\/li\u003e\n      \u003cli\u003eLippi G, Aloe R, Meschi T, Borghi L, Cervellin G. Interference from heterophilic antibodies in troponin testing. \u003cem\u003eClin Chim Acta\u003c\/em\u003e. 2013 Nov 15;426:79-84.\u003c\/li\u003e\n      \u003cli\u003eKawasaki H et al. Minos-insertion mutant of the Drosophila GBA gene homologue showed abnormal phenotypes. \u003cem\u003eGene\u003c\/em\u003e. 2017 May 30;614:49-55.\u003c\/li\u003e\n      \u003cli\u003eHull B. Aberrantly elevated TSH level due to HAMA interference with thyrotropin assay. \u003cem\u003eJ S C Med Assoc\u003c\/em\u003e. 2012 Feb;108(1):12-3.\u003c\/li\u003e\n      \u003cli\u003eDegn SE et al. Assay interference caused by antibodies reacting with rat kappa light-chain in human sera. \u003cem\u003eJ Immunol Methods\u003c\/em\u003e. 2011 Sep 30;372(1-2):204-8.\u003c\/li\u003e\n    \u003c\/ul\u003e\n\n  \u003c\/div\u003e\n\u003c\/div\u003e","brand":"Molecular Depot","offers":[{"title":"600-799 (ng\/mL)","offer_id":50523653800234,"sku":"BTS-S2010006A","price":595.0,"currency_code":"USD","in_stock":true},{"title":"800-999 (ng\/mL)","offer_id":50523653833002,"sku":"BTS-S2010006B","price":795.0,"currency_code":"USD","in_stock":true},{"title":"1000-1499 (ng\/mL)","offer_id":50523653865770,"sku":"BTS-S2010006C","price":995.0,"currency_code":"USD","in_stock":true},{"title":"(1500-1999 ng\/mL)","offer_id":50523824488746,"sku":"BTS-S2010006D","price":1495.0,"currency_code":"USD","in_stock":true},{"title":"(2000-2499 ng\/mL)","offer_id":50523824521514,"sku":"BTS-S2010006E","price":1950.0,"currency_code":"USD","in_stock":true},{"title":"(2500-4999 ng\/mL)","offer_id":50523824554282,"sku":"BTS-S2010006F","price":2995.0,"currency_code":"USD","in_stock":true},{"title":"(5000-7499 ng\/mL)","offer_id":50523824587050,"sku":"BTS-S2010006G","price":3995.0,"currency_code":"USD","in_stock":true},{"title":"(7500-10000 ng\/mL)","offer_id":50523824619818,"sku":"BTS-S2010006H","price":6995.0,"currency_code":"USD","in_stock":true},{"title":"\u003e10000 ng\/mL","offer_id":50523688534314,"sku":"BTS-S2010006I","price":7950.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0896\/1579\/4474\/files\/S2010006_a43295d8-c8cc-48c7-a90e-1d31fb90b8f3.png?v=1755894282"}],"url":"https:\/\/bluetigerscientific.com\/collections\/serum-plasma-1.oembed","provider":"Blue Tiger Scientific","version":"1.0","type":"link"}