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Integrin α5β1 Chimeric Monoclonal Antibody Antibodies Molecular Depot
Integrin α5β1 Chimeric Monoclonal Antibody Antibodies Molecular Depot
Integrin α5β1 Chimeric Monoclonal Antibody Antibodies Molecular Depot
Integrin α5β1 Chimeric Monoclonal Antibody Antibodies Molecular Depot

Integrin α5β1 Chimeric Monoclonal Antibody

$995.00

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What's Included

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VR Headset

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2 Touch Controllers

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Charging Cable

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Power Adapter

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Integrin α5β1 Chimeric Monoclonal Antibody

Catalog number: B2017736
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 100 µg
Molecular Weight or Concentration: N/A
Supplied as: Solution
Applications: a molecular tool for various biochemical applications
Storage: -20°C
Keywords: CD49E, CD29, CD49 Antigen-like Family Member E, Cluster of Differentiation 29, Fibronectin Receptor Subunit α, Fibronectin Receptor Subunit β, GPIIa, ITGA5, ITGB1, Platelet Glycoprotein IIa, Very Late Antigen-5, VLA-4 Subunit β, VLA-5
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References

  • Ricart AD, Tolcher AW, Liu G, Holen K, Schwartz G, Albertini M, Weiss G, Yazji S, Ng C, Wilding G. Volociximab, a chimeric monoclonal antibody that specifically binds alpha5beta1 integrin: a phase I, pharmacokinetic, and biological correlative study Clin Cancer Res. 2008 Dec 1;14(23):7924-9.
  • Almokadem S, Belani CP. Volociximab in cancer Expert Opin Biol Ther. 2012 Feb;12(2):251-7.
  • Bhaskar V, Fox M, Breinberg D, Wong MH, Wales PE, Rhodes S, DuBridge RB, Ramakrishnan V. Volociximab, a chimeric integrin alpha5beta1 antibody, inhibits the growth of VX2 tumors in rabbits Invest New Drugs. 2008 Feb;26(1):7-12.
  • Kuwada SK. Drug evaluation: Volociximab, an angiogenesis-inhibiting chimeric monoclonal antibody Curr Opin Mol Ther. 2007 Feb;9(1):92-8.
  • Ng CM, Bai S, Takimoto CH, Tang MT, Tolcher AW. Mechanism-based receptor-binding model to describe the pharmacokinetic and pharmacodynamic of an anti-α5β1 integrin monoclonal antibody (volociximab) in cancer patients Cancer Chemother Pharmacol. 2010 Jan;65(2):207-17.
  • Ramakrishnan V, Bhaskar V, Law DA, Wong MH, DuBridge RB, Breinberg D, O’Hara C, Powers DB, Liu G, Grove J, Hevezi P, Cass KM, Watson S, Evangelista F, Powers RA, Finck B, Wills M, Caras I, Fang Y, McDonald D, Johnson D, Murray R, Jeffry U. Preclinical evaluation of an anti-alpha5beta1 integrin antibody as a novel anti-angiogenic agent J Exp Ther Oncol. 2006;5(4):273-86.
  • Chung J, Rader C, Popkov M, Hur YM, Kim HK, Lee YJ, Barbas CF 3rd. Integrin alphaIIbbeta3-specific synthetic human monoclonal antibodies and HCDR3 peptides that potently inhibit platelet aggregation FASEB J. 2004 Feb;18(2):361-3.
  • Humphries JD, Schofield NR, Mostafavi-Pour Z, Green LJ, Garratt AN, Mould AP, Humphries MJ. Dual functionality of the anti-beta1 integrin antibody, 12G10, exemplifies agonistic signalling from the ligand binding pocket of integrin adhesion receptors J Biol Chem. 2005 Mar 18;280(11):10234-43.
  • Vella F, Hernandez JF, Molla A, Block MR, Arlaud GJ. Grafting an RGD motif onto an epidermal growth factor-like module: chemical synthesis and functional characterization of the chimeric molecule J Pept Res. 1999 Nov;54(5):415-26.

Product Resources:

Copy of Technical Specifications

FeatureDetails
Viewing Head Siedentopf type trinocular head, inclined at 30°, Interpupillary adjustment 53mm to 75mm, graduated diopter on left eyetube (30mm I.D. eyetubes)
Eyepieces SWH10X Widefield high eyepoint eyepiece, Field No. 22, tube O.D. 30.0 mm
Nosepiece Quintuple
Quintuple LWD Planachromat Phase 10x, 20x
Condenser TC Condenser N.A. 0.30, W.D. 73.0mm
Stage180mm(X) x 245mm(Y) plain stage with replaceable glass insert with 45mm opening, Glass Stage plate insert
IlluminationKoehler without iris, with phase slider, 3W LED
WarrantyLIMITED LIFETIME WARRANTY

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